Question 1

What is Von Willebrand Disease?

Accepted Answer

Von Willebrand Disease is an inherited bleeding disorder that affects how blood clots. It is caused by a deficiency or dysfunction of von Willebrand factor, a protein essential for platelet adhesion and clot formation. The Prothrombin Time and Partial Thromboplastin Time test is the most important initial screening test for diagnosing this genetic clotting disorder.

Question 2

What causes Von Willebrand Disease?

Accepted Answer

Von Willebrand Disease is caused by genetic mutations that affect the production or function of von Willebrand factor, a blood protein critical for clotting. These mutations can be inherited from one or both parents in an autosomal dominant or recessive pattern. When von Willebrand factor is deficient or dysfunctional, platelets cannot stick together properly to form blood clots, leading to prolonged bleeding episodes after injuries, surgeries, dental procedures, or even spontaneously from mucous membranes.

Question 3

What is the best test for Von Willebrand Disease?

Accepted Answer

The Prothrombin Time and Partial Thromboplastin Time test is the most important initial screening test for Von Willebrand Disease because it measures how long blood takes to clot. People with VWD typically show a prolonged PTT result because their deficient or dysfunctional von Willebrand factor prevents normal clot formation. While this test identifies clotting abnormalities, your doctor may order additional specialized tests like von Willebrand factor antigen, von Willebrand factor activity, and Factor VIII levels to confirm the diagnosis and determine the specific type and severity of the disease.

Question 4

When should I get tested for Von Willebrand Disease?

Accepted Answer

You should get tested if you experience frequent nosebleeds that are hard to stop, easy bruising without known injury, prolonged bleeding from cuts or after dental work, heavy menstrual periods lasting more than seven days, or if you have a family history of bleeding disorders. Testing is especially important before scheduled surgeries or dental procedures, as undiagnosed VWD can lead to dangerous bleeding complications. Women planning pregnancy should also consider testing since VWD can cause complications during childbirth.

Question 5

What are the symptoms of Von Willebrand Disease?

Accepted Answer

Von Willebrand Disease symptoms include frequent or prolonged nosebleeds, easy bruising, bleeding gums after brushing teeth, heavy or prolonged menstrual bleeding, blood in urine or stool, and excessive bleeding after cuts, surgeries, or dental procedures. Some people experience bleeding into joints or muscles, though this is more common in severe cases. Symptoms can range from mild to severe depending on the type and severity of the factor deficiency, with some people only discovering they have VWD after a surgical procedure or significant injury.

Question 6

Who is at risk for Von Willebrand Disease?

Accepted Answer

Anyone with a family history of Von Willebrand Disease or unexplained bleeding disorders is at higher risk, as the condition is inherited genetically. VWD affects both men and women equally, though women may notice symptoms more due to menstruation and childbirth. People with blood type O tend to have naturally lower von Willebrand factor levels and may experience more noticeable symptoms. The condition affects approximately 1 in 100 people, making it the most common inherited bleeding disorder, though many cases go undiagnosed because symptoms can be mild.

Question 7

What happens if Von Willebrand Disease is left untreated?

Accepted Answer

Untreated Von Willebrand Disease can lead to severe bleeding complications during surgeries, dental procedures, or after injuries that could become life-threatening. Women with undiagnosed VWD may experience dangerously heavy menstrual bleeding leading to chronic anemia and fatigue. Childbirth becomes particularly risky with potential for postpartum hemorrhage. Repeated bleeding into joints can cause chronic joint damage and arthritis over time. Getting diagnosed and managing VWD properly allows you to take preventive measures before procedures and receive appropriate treatment when bleeding occurs.

Question 8

Can Von Willebrand Disease be diagnosed with a blood test?

Accepted Answer

Yes, Von Willebrand Disease is diagnosed through blood tests that measure clotting function and von Willebrand factor levels. The initial screening typically includes a Partial Thromboplastin Time test which shows prolonged clotting in people with VWD. Confirmatory tests measure von Willebrand factor antigen levels, von Willebrand factor activity, and Factor VIII levels to determine the type and severity of the disease. Multiple blood tests may be needed because von Willebrand factor levels can fluctuate with stress, exercise, pregnancy, or hormonal changes.

Question 9

How is Von Willebrand Disease treated?

Accepted Answer

Von Willebrand Disease treatment depends on the type and severity of the condition. Desmopressin, a synthetic hormone, is commonly used to stimulate the release of stored von Willebrand factor for mild to moderate cases. Factor replacement therapy using concentrates containing von Willebrand factor and Factor VIII may be needed for severe cases or before surgeries. Antifibrinolytic medications like tranexamic acid help prevent clot breakdown and control bleeding. Women with heavy menstrual bleeding may benefit from hormonal birth control to regulate periods and reduce blood loss.

Question 10

How can I prevent complications from Von Willebrand Disease?

Accepted Answer

Preventing complications involves avoiding medications that interfere with clotting, particularly aspirin, ibuprofen, and other nonsteroidal anti-inflammatory drugs unless approved by your doctor. Always inform healthcare providers, dentists, and surgeons about your VWD diagnosis before any procedures so they can take appropriate precautions. Wear a medical alert bracelet identifying your bleeding disorder. Avoid contact sports or activities with high injury risk, or take extra precautions when participating. Regular follow-up with a hematologist helps monitor your condition and adjust treatment as needed.

Question 11

What can I do at home for Von Willebrand Disease?

Accepted Answer

At home, apply direct pressure and ice to cuts or nosebleeds for at least 15-20 minutes to help stop bleeding. Keep a well-stocked first aid kit with gauze, bandages, and ice packs readily available. Maintain good oral hygiene with a soft toothbrush to prevent gum bleeding, and consider using a humidifier to prevent dry nasal passages that can trigger nosebleeds. Eat an iron-rich diet including lean meats, leafy greens, and fortified cereals to help prevent anemia from chronic blood loss. Keep detailed records of bleeding episodes to share with your healthcare provider for better treatment management.

Question 12

How’s this work?

Accepted Answer

Getting your blood test with us is easy, private & backed by the power of science.Long story short:
            
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Question 13

How do I know which test to get?

Accepted Answer

In the test options, find the test you want.
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Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
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Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

Absolutely! We totally understand that errors can happen. No worries, we're here to help you.
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            Our lab requires an address to be listed to generate an order.

Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
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Question 17

Can I cancel my order?

Accepted Answer

Yes.
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Question 18

How can I find a lab location near me?

Accepted Answer

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached!
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Von Willebrand Disease Blood Test

What is Von Willebrand Disease?

What causes Von Willebrand Disease?

What is the best test for Von Willebrand Disease?

When should I get tested for Von Willebrand Disease?

References

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