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Vitamin B6 deficiency is a condition where the body has inadequate levels of pyridoxine, a water-soluble vitamin essential for protein metabolism, neurotransmitter synthesis, and immune function. It is caused by insufficient dietary intake, malabsorption disorders, certain medications, or chronic kidney disease. The Vitamin B6 blood test is the most important test for diagnosis because it directly measures pyridoxine levels in the bloodstream.
Vitamin B6 deficiency is caused by insufficient dietary intake, malabsorption disorders, certain medications, or chronic kidney disease. Common dietary causes include not eating enough foods rich in vitamin B6 like poultry, fish, potatoes, and non-citrus fruits. Medications such as isoniazid, penicillamine, and some anticonvulsants can interfere with vitamin B6 absorption or metabolism. People with Crohn disease, celiac disease, ulcerative colitis, or chronic kidney disease are at particularly high risk because their bodies cannot properly absorb or process this essential vitamin.
The Vitamin B6 blood test is the most important test for diagnosing vitamin B6 deficiency because it directly measures pyridoxine levels in your bloodstream. This test provides a definitive diagnosis by detecting low vitamin B6 status before severe symptoms develop, making it essential for early intervention. The test measures the concentration of pyridoxal 5-phosphate, the active form of vitamin B6, which accurately reflects your body's vitamin B6 stores. This blood test is also crucial for monitoring treatment effectiveness once you begin supplementation or dietary changes to correct the deficiency.
You should get tested if you experience symptoms like persistent skin rashes (especially around the mouth and eyes), mood changes including depression or irritability, weakened immune function with frequent infections, unexplained fatigue, or tingling and numbness in your hands and feet. Testing is particularly important if you are elderly, have a malabsorption disorder like Crohn disease or celiac disease, take medications that interfere with B6 metabolism, follow a restrictive diet, or have chronic kidney disease. Early testing helps prevent more serious complications like peripheral neuropathy and severe anemia.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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