Uveitis Blood Test

What is Uveitis?

Uveitis is an inflammation of the uvea, the middle layer of the eye that includes the iris, ciliary body, and choroid. It is caused by genetic factors like HLA-B27 antigen, infections such as Human T-Cell Lymphotropic Virus (HTLV), or autoimmune conditions. The HLA-B27 Antigen test is the most important test for identifying genetic predisposition to uveitis.

RECOMMENDED TEST HLA-B27 Antigen
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What causes uveitis?

Uveitis is caused by genetic factors, infections, autoimmune diseases, and inflammatory conditions. The HLA-B27 antigen is a genetic marker strongly associated with developing uveitis, particularly anterior uveitis affecting the front of the eye. Infections like Human T-Cell Lymphotropic Virus type I (HTLV-I), toxoplasmosis, herpes viruses, and tuberculosis can trigger eye inflammation. Autoimmune conditions such as rheumatoid arthritis, ankylosing spondylitis, and inflammatory bowel disease are also common causes of uveitis.

What is the best test for uveitis?

The HLA-B27 Antigen test is the most important blood test for uveitis because it identifies genetic predisposition to this inflammatory eye condition. Studies show a significantly higher prevalence of HLA-B27 in patients with uveitis, especially those with acute anterior uveitis. If viral infection is suspected, the Human T-Cell Lymphotropic Virus I, II (HTLV-I/HTLV-II) Antibodies test is essential for detecting HTLV-related uveitis. The HLA B Low Resolution test provides broader genetic typing that includes HLA-B27 and can reveal additional genetic risk factors. These tests help identify underlying causes and guide your doctor toward the most effective treatment approach.

When should I get tested for uveitis?

You should get tested if you experience eye redness, pain, blurred vision, light sensitivity, or floaters that do not improve quickly. Testing is especially important if you have recurrent episodes of eye inflammation, a family history of uveitis or autoimmune diseases, or known conditions like ankylosing spondylitis or inflammatory bowel disease. If you have persistent eye discomfort lasting more than a few days or sudden vision changes, blood testing can help identify genetic factors or infections contributing to your symptoms and prevent potential vision loss.

What are the symptoms of uveitis?
Uveitis symptoms include eye redness, pain, blurred or decreased vision, and sensitivity to light (photophobia). You might notice floaters appearing as dark spots or squiggly lines in your vision. The affected eye may feel tender or achy, and you may experience tearing or excessive discharge. Symptoms can develop suddenly and worsen rapidly, or they may come on gradually. Some people experience recurrent episodes with periods of remission. If you notice any combination of these symptoms, especially sudden vision changes or severe eye pain, seek evaluation promptly to prevent complications.
Who is at risk for uveitis?
People with the HLA-B27 genetic marker have significantly higher risk of developing uveitis. Those with autoimmune conditions like rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, or inflammatory bowel disease are at increased risk. Individuals with infections such as HTLV-I, tuberculosis, syphilis, toxoplasmosis, or herpes viruses can develop uveitis as a complication. Smokers have higher risk, and uveitis can affect people of any age, though certain types are more common in young to middle-aged adults. A family history of uveitis or autoimmune diseases also increases your susceptibility.
What happens if uveitis is left untreated?
Untreated uveitis can lead to serious and permanent vision complications. You may develop glaucoma from increased eye pressure, cataracts causing clouding of the lens, retinal swelling or detachment, and permanent vision loss or blindness. Chronic inflammation can damage the optic nerve and other delicate eye structures. The condition may spread to other parts of the eye, worsening the inflammation and increasing the risk of complications. Early detection through blood testing to identify underlying causes, combined with prompt treatment, is crucial for preserving your vision and preventing irreversible damage to your eyes.
Can uveitis be diagnosed with a blood test?
Blood tests cannot diagnose uveitis directly, but they play a crucial supporting role in identifying underlying causes and risk factors. The HLA-B27 Antigen test reveals genetic predisposition, while HTLV antibody tests detect viral infections that may trigger uveitis. Your eye doctor will diagnose uveitis through a comprehensive eye examination using specialized equipment to view the inside of your eye. Blood tests complement the eye exam by uncovering infections, autoimmune markers, and genetic factors that explain why the inflammation developed. This information helps your healthcare team create a targeted treatment plan and monitor for related systemic conditions.
How is uveitis treated?
Uveitis treatment depends on the underlying cause identified through testing. Corticosteroid eye drops, injections, or oral medications reduce inflammation and prevent damage. If blood tests reveal HLA-B27 positivity or autoimmune conditions, immunosuppressive medications may be prescribed to control the immune response. For infectious causes like HTLV or herpes viruses, antiviral or antibiotic medications target the specific infection. Dilating eye drops help reduce pain and prevent complications. In severe or chronic cases, biologic medications or surgical interventions may be necessary. Your treatment plan is tailored based on blood test results, the type and location of inflammation, and your overall health.
How can I prevent uveitis?
Preventing uveitis focuses on managing risk factors and treating underlying conditions. If you have autoimmune diseases, maintaining consistent treatment helps prevent inflammation from affecting your eyes. Protect yourself from infections by practicing good hygiene, avoiding exposure to infectious diseases, and seeking prompt treatment for infections. If you are HLA-B27 positive, regular monitoring and early intervention at the first signs of eye inflammation can prevent severe episodes. Avoid smoking, which increases uveitis risk. Wear protective eyewear to prevent eye injuries that can trigger inflammation. Regular eye exams help detect early signs of inflammation before symptoms become severe.
What can I do at home for uveitis?
While professional medical treatment is essential for uveitis, you can support your eye health at home with several strategies. Wear sunglasses to reduce light sensitivity and protect your eyes from bright light and UV exposure. Apply cool compresses to your closed eyes to soothe discomfort and reduce swelling. Rest your eyes frequently if you experience blurred vision or eye strain. Maintain a healthy diet rich in omega-3 fatty acids, vitamins A, C, and E, and antioxidants to support eye health and reduce inflammation. Avoid rubbing your eyes, which can worsen inflammation. Follow your prescribed medication schedule carefully and attend all follow-up appointments to monitor your condition and prevent complications.
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As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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HLA-B27 Antigen
Google reviews 505 reviews
$324 $253
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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