Tree nut allergy is an immune system overreaction to proteins found in nuts such as almonds, cashews, hazelnuts, and walnuts. It is caused by the production of Immunoglobulin E (IgE) antibodies that trigger allergic reactions ranging from mild skin rashes to life-threatening anaphylaxis. The Food Allergen Profile, IgE With Component Reflexes is the most important test for diagnosis because it measures specific IgE antibodies to multiple tree nuts and provides component reflex testing for precise allergen protein identification.
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Tree nut allergy is caused by your immune system mistakenly identifying proteins in tree nuts as harmful invaders. When you eat or come into contact with tree nuts like almonds, cashews, hazelnuts, or walnuts, your body produces Immunoglobulin E (IgE) antibodies that trigger the release of histamine and other chemicals. This immune response causes allergic symptoms that can range from mild itching and hives to severe reactions like difficulty breathing and anaphylactic shock. The exact reason why some people develop this immune response while others do not is not fully understood, but genetics and early exposure patterns play significant roles.
The Food Allergen Profile, IgE With Component Reflexes is the most important test for tree nut allergy because it measures specific IgE antibodies to multiple tree nuts including almonds, cashews, hazelnuts, and walnuts in a single comprehensive panel. This test provides component reflex testing that analyzes specific allergen proteins, giving you precise information about which protein components trigger your reactions and helping predict the severity of potential allergic responses. For people experiencing delayed symptoms or chronic issues, the IgG4 Food Panel IV can detect delayed immune responses to tree nuts by measuring IgG4 antibodies. Together, these tests provide a complete picture of both immediate IgE-mediated allergies and delayed sensitivities.
You should get tested if you experience symptoms like hives, itching, swelling of the lips or throat, stomach cramps, or difficulty breathing after eating tree nuts or foods that might contain them. Testing is also important if you have a family history of food allergies, if your child has eczema or other food allergies, or if you have had any previous allergic reaction to nuts even if it was mild. Early and accurate diagnosis is critical because tree nut allergies can be life-threatening and symptoms can worsen with repeated exposure, so getting tested helps you know which specific nuts to avoid and whether you need to carry emergency epinephrine.
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What this means
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Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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