Tramadol dependence or addiction is a condition where the body becomes physically or psychologically reliant on tramadol, an opioid pain medication. It is caused by chronic use of tramadol leading to changes in brain chemistry, particularly affecting opioid receptors and neurotransmitter systems. The Tramadol and Metabolite, Serum/Plasma test is the most important test for monitoring tramadol levels and detecting potential abuse patterns.
90-day money-back guarantee
Lab order in minutes
Save a trip to the doctor
Low prices since 2005
Labs within 2 miles
Tramadol dependence or addiction is caused by repeated exposure to tramadol, which alters brain chemistry and creates physical and psychological reliance on the drug. Tramadol works by binding to opioid receptors in the brain and inhibiting the reuptake of serotonin and norepinephrine, which produces pain relief and feelings of euphoria. Over time, the brain adapts to the presence of tramadol, requiring higher doses to achieve the same effects and triggering withdrawal symptoms when use is reduced or stopped.
The Tramadol and Metabolite, Serum/Plasma test is the most important test for tramadol dependence because it measures both tramadol and its metabolites in the blood, providing objective evidence of drug levels and usage patterns. This test helps healthcare providers identify chronic, elevated levels that suggest potential abuse or addiction, monitor compliance with prescribed dosages, and detect unauthorized use. The test results are essential for creating comprehensive treatment plans, adjusting therapeutic interventions, and tracking recovery progress. By measuring both the parent drug and its metabolites, this test provides a complete picture of tramadol use and metabolism in the body.
You should get tested if you are taking tramadol and notice signs of increasing tolerance, such as needing higher doses for pain relief, experiencing cravings when not taking the medication, or having difficulty controlling your use. Testing is also important if you are experiencing withdrawal symptoms like anxiety, sweating, nausea, or insomnia when trying to reduce your dosage. Healthcare providers may recommend testing as part of addiction treatment monitoring, to verify compliance with prescribed dosages, or if there are concerns about potential abuse or diversion of the medication.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.
505 reviews
Sample results
Your 24/7 Lab Guide
Quick questions:
