Question 1

What is Systemic Sclerosis (Scleroderma)?

Accepted Answer

Systemic Sclerosis, also known as scleroderma, is a chronic autoimmune disorder that causes hardening and tightening of the skin and connective tissues. It is caused by overproduction of collagen due to immune system dysfunction that attacks healthy tissue. The ANA Screen IFA with Reflex to Titer and Pattern is the most important test for diagnosis because it detects specific autoantibodies present in most scleroderma patients.

Question 2

What causes Systemic Sclerosis (Scleroderma)?

Accepted Answer

Systemic Sclerosis is caused by an overactive immune system that mistakenly attacks healthy connective tissue, leading to excessive collagen production. This autoimmune response causes the skin, blood vessels, and internal organs to become thick and hard. While the exact trigger is unknown, genetic factors, environmental exposures, and certain viral infections may play a role in activating the immune system dysfunction that leads to scleroderma.

Question 3

What is the best test for Systemic Sclerosis (Scleroderma)?

Accepted Answer

The ANA Screen IFA with Reflex to Titer and Pattern is the most important test for Systemic Sclerosis because it detects antinuclear antibodies present in approximately 95% of scleroderma patients. This test uses immunofluorescence to identify specific autoantibody patterns that help distinguish scleroderma from other autoimmune conditions. High ANA levels with characteristic patterns such as nucleolar or centromere patterns strongly support the diagnosis. The Anti-dsDNA test may provide additional immunological information in select cases where a comprehensive autoimmune profile is needed.

Question 4

When should I get tested for Systemic Sclerosis (Scleroderma)?

Accepted Answer

You should get tested if you notice skin thickening or tightening, especially on your fingers, hands, or face. Other warning signs include Raynaud's phenomenon where your fingers turn white or blue in cold temperatures, persistent heartburn or difficulty swallowing, unexplained shortness of breath, or joint pain and stiffness. Early testing is particularly important if you have a family history of autoimmune diseases or if your symptoms are progressively worsening, as early diagnosis allows for better management of organ involvement.

Question 5

What are the symptoms of Systemic Sclerosis (Scleroderma)?

Accepted Answer

Systemic Sclerosis symptoms include skin thickening and hardening that typically starts in the fingers and hands, Raynaud's phenomenon causing color changes in fingers and toes when exposed to cold, and persistent digestive issues like heartburn and difficulty swallowing. You might also experience shortness of breath, fatigue, joint pain and stiffness, muscle weakness, and the appearance of small red spots on the skin called telangiectasias. Some people develop calcium deposits under the skin or experience kidney problems and high blood pressure.

Question 6

Who is at risk for Systemic Sclerosis (Scleroderma)?

Accepted Answer

Women between ages 30 and 50 are at highest risk for developing Systemic Sclerosis, with the condition affecting women about four times more often than men. People with a family history of scleroderma or other autoimmune diseases have increased risk. Certain occupational exposures to silica dust, organic solvents, or vinyl chloride may elevate risk. African American women tend to develop more severe forms of the disease at younger ages compared to other ethnic groups.

Question 7

What happens if Systemic Sclerosis (Scleroderma) is left untreated?

Accepted Answer

Untreated Systemic Sclerosis can lead to serious organ damage and life-threatening complications. The lungs may develop scarring (pulmonary fibrosis) or increased blood pressure in lung arteries, causing severe breathing difficulties. The heart can be affected with abnormal rhythms or heart failure. Kidney crisis with dangerously high blood pressure can occur suddenly. The digestive system may develop severe problems with swallowing and nutrient absorption. Early diagnosis and treatment are essential to slow disease progression and prevent irreversible organ damage.

Question 8

Can Systemic Sclerosis (Scleroderma) be diagnosed with a blood test?

Accepted Answer

Blood tests are essential for diagnosing Systemic Sclerosis but are used alongside physical examination and medical history. The ANA Screen IFA test detects autoantibodies present in the vast majority of scleroderma patients and helps confirm the diagnosis. Specific autoantibody patterns can also help identify disease subtypes and predict which organs might be affected. While blood tests cannot diagnose scleroderma by themselves, they provide critical information that supports clinical findings and guides treatment decisions.

Question 9

How is Systemic Sclerosis (Scleroderma) treated?

Accepted Answer

Systemic Sclerosis treatment focuses on managing symptoms and preventing organ damage through medications that suppress the immune system, such as methotrexate or mycophenolate. Blood pressure medications called ACE inhibitors protect the kidneys and help with Raynaud's phenomenon. Immunosuppressive drugs may slow skin thickening and lung involvement. Physical therapy maintains joint flexibility and skin elasticity. Treatment is individualized based on which organs are affected, with regular monitoring through blood tests and imaging to track disease progression and adjust medications accordingly.

Question 10

How can I prevent Systemic Sclerosis (Scleroderma)?

Accepted Answer

Systemic Sclerosis cannot be prevented because it is an autoimmune condition with no known definitive cause. However, you can reduce risk of triggering or worsening symptoms by avoiding exposure to silica dust and organic solvents in occupational settings. Protecting yourself from cold temperatures helps prevent Raynaud's attacks. Avoiding smoking is crucial as it worsens blood vessel problems and lung complications. If you have a family history of autoimmune diseases, staying aware of early symptoms allows for prompt diagnosis and treatment, which can slow disease progression.

Question 11

What can I do at home for Systemic Sclerosis (Scleroderma)?

Accepted Answer

At home, you can manage Systemic Sclerosis symptoms by keeping your body warm and wearing gloves in cold weather to prevent Raynaud's attacks. Gentle stretching exercises and hand therapy maintain flexibility and prevent joint stiffness. Elevate the head of your bed to reduce nighttime heartburn and acid reflux. Use moisturizers regularly to keep skin supple and prevent cracking. Eat smaller, more frequent meals and avoid foods that trigger reflux. Stay physically active within your limits to maintain muscle strength and joint mobility, and manage stress through relaxation techniques as stress can worsen symptoms.

Question 12

How’s this work?

Accepted Answer

Getting your blood test with us is easy, private & backed by the power of science.Long story short:
            
                In the test options, use the filters or search box to narrow your choices and find the test you want.
                If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
                Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
                If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
                When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
                Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
                You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
                If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

Question 13

How do I know which test to get?

Accepted Answer

In the test options, find the test you want.
            If you’re not sure which test to get, we can lend a hand in finding the right option.
            Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
            After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop!
            If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

Absolutely! We totally understand that errors can happen. No worries, we're here to help you.
            Just reach out to us via text at 754-799-7833 or shoot us an email at
            support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update.
            Our awesome team will jump right in and make sure everything is sorted out and accurate for you.
            There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.
            Our lab requires an address to be listed to generate an order.

Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
            Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.
            This policy applies to all insurance companies, including federal health insurance programs like Medicare.
            If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Question 17

Can I cancel my order?

Accepted Answer

Yes.
            We get it – sometimes your needs change.
            As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.
            If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
            You can read more about our cancellation policy here.

Question 18

How can I find a lab location near me?

Accepted Answer

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached!
            You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).
            Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.
            If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

Systemic Sclerosis (Scleroderma) Blood Test

What is Systemic Sclerosis (Scleroderma)?

What causes Systemic Sclerosis (Scleroderma)?

What is the best test for Systemic Sclerosis (Scleroderma)?

When should I get tested for Systemic Sclerosis (Scleroderma)?

References

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