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Sjogren's Syndrome is an autoimmune disorder where the immune system attacks glands that produce tears and saliva, causing chronic dry eyes and dry mouth. It is caused by the immune system mistakenly targeting healthy moisture-producing cells, often with elevated autoimmune antibodies like anti-SSA, anti-SSB, and Rheumatoid Factor. The Rheumatoid Arthritis Diagnostic Panel 1 is the most important test for diagnosis as it detects Rheumatoid Factor, which is frequently elevated in Sjogren's Syndrome patients.
Sjogren's Syndrome is caused by an autoimmune response where your immune system mistakenly attacks the glands that produce tears and saliva. White blood cells called lymphocytes infiltrate these moisture-producing glands and damage them, leading to inflammation and reduced secretion. The exact trigger is unknown, but genetic factors combined with viral infections like Epstein-Barr virus may activate this autoimmune response in susceptible individuals.
The Rheumatoid Arthritis Diagnostic Panel 1 is the most important test for Sjogren's Syndrome because it detects Rheumatoid Factor, which is elevated in about 60-70% of Sjogren's patients. This autoantibody indicates active autoimmune disease and helps distinguish Sjogren's from simple dry eye or dry mouth caused by medications or aging. Additional tests like the Anti-dsDNA Antibodies test and PCNA Antibody test can help identify overlapping autoimmune features and confirm the diagnosis when combined with clinical symptoms.
You should get tested if you experience persistent dry eyes that feel gritty or burning, chronic dry mouth that makes swallowing difficult, or dental cavities that develop rapidly despite good oral hygiene. Testing is especially important if you have other autoimmune conditions like rheumatoid arthritis or lupus, since Sjogren's often occurs alongside these diseases. You should also consider testing if you experience unexplained joint pain, chronic fatigue, or swollen salivary glands that last more than a few weeks.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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