Shingles Blood Test

What is Shingles (Herpes Zoster)?

Shingles (herpes zoster) is a painful viral infection characterized by a blistering rash that typically appears on one side of the body. It is caused by the reactivation of the varicella-zoster virus (VZV), the same virus that causes chickenpox, which remains dormant in nerve tissue after the initial infection. The Varicella-Zoster Virus (VZV) Antibodies, IgG test is the most important test for confirming immune response and viral exposure related to shingles.

RECOMMENDED TEST Varicella-Zoster Virus (VZV) Antibodies, IgG (Chickenpox)
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What causes shingles?

Shingles is caused by the reactivation of the varicella-zoster virus (VZV), the same virus responsible for chickenpox. After you recover from chickenpox, usually during childhood, the virus remains dormant in nerve tissue near your spinal cord and brain. Years or decades later, the virus can reactivate and travel along nerve pathways to your skin, producing the painful rash characteristic of shingles. This reactivation typically occurs when your immune system weakens due to aging, stress, certain medications, or other health conditions that compromise immunity.

What is the best test for shingles?

The Varicella-Zoster Virus (VZV) Antibodies, IgG test is the most important blood test for shingles because it measures your immune system's antibody response to the varicella-zoster virus. This test confirms whether you have been exposed to VZV and helps assess your immune status, which is particularly valuable when the clinical presentation is unclear or in cases where confirmation of viral exposure is needed. Elevated VZV IgG antibody levels indicate that your body has mounted an immune response to the virus, supporting the diagnosis of shingles. While shingles is primarily diagnosed through clinical examination of the characteristic rash, this blood test provides essential supporting information about viral activity and immune response.

When should I get tested for shingles?

You should get tested if you develop a painful, blistering rash on one side of your body, especially if you have a weakened immune system or are over 50 years old. Testing is also recommended if you experience burning, tingling, or numbness in a specific area before a rash appears, or if your healthcare provider needs to confirm VZV exposure in atypical cases. Additionally, if you have risk factors such as cancer, HIV, or are taking immunosuppressive medications, testing can help your doctor understand your immune status and guide appropriate treatment decisions.

What are the symptoms of shingles?
Shingles symptoms typically begin with pain, burning, numbness, or tingling in a specific area on one side of your body. Within a few days, a red rash develops in the same area, followed by fluid-filled blisters that eventually break open and crust over. You might also experience fever, headache, fatigue, and sensitivity to light. The pain can be severe and is often described as sharp, stabbing, or throbbing, and it usually affects a band or strip of skin on one side of your torso, though it can occur on your face, neck, or other areas.
Who is at risk for shingles?
Anyone who has had chickenpox is at risk for shingles because the varicella-zoster virus remains in your body for life. Your risk increases significantly after age 50, with about half of all shingles cases occurring in people over 60. People with weakened immune systems due to HIV, cancer, chemotherapy, organ transplants, or immunosuppressive medications face higher risk. Chronic stress, physical trauma, and certain chronic diseases like diabetes also increase your likelihood of developing shingles.
What happens if shingles is left untreated?
Untreated shingles can lead to postherpetic neuralgia, a condition where severe nerve pain persists for months or years after the rash heals, affecting up to 20% of shingles patients. Other serious complications include vision loss if the virus affects your eye (ophthalmic shingles), hearing problems, facial paralysis, and bacterial skin infections from the blisters. In rare cases, shingles can cause brain inflammation (encephalitis), pneumonia, or widespread infection, particularly in people with compromised immune systems. Early treatment with antiviral medications can significantly reduce the severity and duration of symptoms and lower your risk of complications.
Can shingles be diagnosed with a blood test?
Shingles is primarily diagnosed through clinical examination of the characteristic rash and symptoms, but blood tests can provide valuable supporting information. The Varicella-Zoster Virus (VZV) Antibodies, IgG test confirms your immune status and history of VZV exposure, which is helpful when the clinical presentation is atypical or unclear. While there is no single blood test that definitively diagnoses an active shingles outbreak, antibody testing helps healthcare providers understand your viral exposure history and immune response, which can guide treatment decisions and confirm the diagnosis in uncertain cases.
How is shingles treated?
Shingles is treated primarily with antiviral medications like acyclovir, valacyclovir, or famciclovir, which are most effective when started within 72 hours of rash onset. These medications help reduce the severity and duration of symptoms, speed healing, and lower your risk of complications like postherpetic neuralgia. Pain management includes over-the-counter pain relievers, prescription pain medications, numbing creams or patches, and sometimes anticonvulsants or antidepressants for nerve pain. Cool compresses, calamine lotion, and oatmeal baths can soothe the rash and reduce itching.
How can I prevent shingles?
The most effective prevention is the shingles vaccine, which is recommended for adults over 50 even if they have already had shingles or chickenpox. The Shingrix vaccine is more than 90% effective at preventing shingles and postherpetic neuralgia. Maintaining a strong immune system through healthy lifestyle habits also helps reduce your risk: eat a balanced diet rich in vitamins and minerals, exercise regularly, manage stress effectively, get adequate sleep, and avoid smoking. If you have never had chickenpox, getting the chickenpox vaccine can prevent both chickenpox and the later possibility of shingles.
What natural remedies help with shingles?
Natural remedies can help manage shingles symptoms alongside medical treatment, though they should not replace antiviral medication. Cool, wet compresses applied to the rash can soothe pain and itching, while oatmeal baths provide relief for widespread discomfort. Lysine supplements may help inhibit viral replication, and topical applications of calamine lotion or aloe vera gel can calm irritated skin. Foods rich in vitamins A, B12, C, and E support immune function and healing, including citrus fruits, leafy greens, nuts, and lean proteins. Stress reduction techniques like meditation, gentle yoga, and adequate rest support your immune system's ability to fight the virus.
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Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

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As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Varicella-Zoster Virus (VZV) Antibodies, IgG (Chickenpox)
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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