Shellfish Allergy Blood Test

What is Shellfish Allergy?

Shellfish allergy is an abnormal immune response to proteins found in marine shellfish such as shrimp, crab, lobster, and clams. It is caused by the immune system producing IgE and IgG4 antibodies that mistakenly identify shellfish proteins as harmful invaders. The Allergy-Shellfish Panel is the most important test for diagnosis because it measures specific antibodies to multiple shellfish types in a single comprehensive panel.

RECOMMENDED TEST Allergy-Shellfish Panel
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What causes shellfish allergy?

Shellfish allergy is caused by an abnormal immune response to specific proteins found in shellfish such as tropomyosin, which is the primary allergen in crustaceans like shrimp, crab, and lobster. When you eat shellfish, your immune system mistakenly identifies these proteins as dangerous invaders and produces antibodies called immunoglobulin E (IgE) and immunoglobulin G4 (IgG4) to fight them. This immune reaction triggers the release of histamine and other chemicals that cause allergic symptoms ranging from mild skin reactions to life-threatening anaphylaxis.

What is the best test for shellfish allergy?

The Allergy-Shellfish Panel is the most important test for shellfish allergy because it measures specific IgE antibodies to multiple types of shellfish including clams, crab, lobster, and shrimp in one comprehensive analysis. This panel identifies which specific shellfish trigger your immune system and helps determine the severity of your allergic response. For more detailed analysis, the Food Allergen Profile, IgE With Component Reflexes provides advanced testing for scallops and shrimp with component-level precision, while the IgG4 Food Panels (III, IV, and VI) measure IgG4 antibodies that can reveal additional immune responses to shrimp, clams, lobster, and crab proteins.

When should I get tested for shellfish allergy?

You should get tested if you experience symptoms like hives, itching, swelling of the lips or face, stomach cramps, vomiting, or difficulty breathing within minutes to hours after eating shellfish. Testing is also important if you have a family history of shellfish allergy, have experienced unexplained anaphylaxis, or need to confirm whether you can safely eat certain types of shellfish while avoiding others. Early testing helps you avoid potentially life-threatening reactions and allows your doctor to create an emergency action plan with epinephrine auto-injectors if needed.

What are the symptoms of shellfish allergy?
Shellfish allergy symptoms typically appear within minutes to two hours after eating shellfish and range from mild to severe. Common symptoms include skin reactions like hives, itching, or eczema, digestive problems such as nausea, vomiting, stomach cramps, and diarrhea, and respiratory issues including nasal congestion, wheezing, or difficulty breathing. In severe cases, shellfish allergy can cause anaphylaxis, a life-threatening reaction that includes a rapid drop in blood pressure, dizziness, loss of consciousness, rapid pulse, and throat swelling that makes breathing difficult.
Who is at risk for shellfish allergy?
Adults are at higher risk for developing shellfish allergy compared to children, as this allergy commonly appears in adulthood rather than childhood. People with other allergies such as asthma, eczema, or hay fever have an increased risk, as do those with a family history of food allergies or shellfish allergy specifically. Individuals who work in seafood processing or restaurant kitchens face higher exposure and may develop the allergy through repeated contact. Unlike many childhood food allergies, shellfish allergy tends to be lifelong and rarely goes away once developed.
What happens if shellfish allergy is left untreated?
If shellfish allergy is left undiagnosed or untreated, you risk experiencing repeated allergic reactions that can progressively worsen over time. Each exposure to shellfish proteins can trigger more severe symptoms, and without proper diagnosis and an emergency action plan, you may not have life-saving epinephrine available during anaphylaxis. Unmanaged shellfish allergy can lead to accidental exposure through cross-contamination in restaurants or processed foods, resulting in emergency room visits or potentially fatal reactions. Chronic exposure and repeated reactions can also cause ongoing inflammation and digestive problems that affect your quality of life.
Can shellfish allergy be diagnosed with a blood test?
Yes, shellfish allergy can be accurately diagnosed with blood tests that measure specific IgE and IgG4 antibodies your immune system produces in response to shellfish proteins. Blood tests are safer than oral food challenges because they do not expose you to allergens that could trigger dangerous reactions. These tests identify which specific types of shellfish you are allergic to and measure the levels of antibodies, helping your doctor assess the severity of your allergy and create an appropriate management plan with emergency medications if needed.
How is shellfish allergy treated?
Shellfish allergy is treated primarily through strict avoidance of all shellfish and careful reading of food labels to prevent accidental exposure. Your doctor will prescribe an epinephrine auto-injector (EpiPen) that you must carry at all times for emergency treatment of severe reactions or anaphylaxis. Antihistamines can help manage mild symptoms like hives or itching, but they cannot stop anaphylaxis. You should wear a medical alert bracelet, inform restaurants about your allergy to prevent cross-contamination, and develop a written emergency action plan with your healthcare provider that outlines steps to take if you accidentally consume shellfish.
How can I prevent shellfish allergy reactions?
You can prevent shellfish allergy reactions by completely avoiding all shellfish including shrimp, crab, lobster, clams, oysters, scallops, and mussels, as well as any foods containing shellfish ingredients. Always read food labels carefully and look for warnings about shellfish or cross-contamination with shellfish products. When dining out, inform restaurant staff about your allergy and ask about ingredients and preparation methods to avoid cross-contact with shellfish. Be cautious with Asian cuisine, seafood restaurants, and buffets where cross-contamination is common, and carry your epinephrine auto-injector everywhere you go.
What can I do at home for shellfish allergy symptoms?
At home, you can manage mild shellfish allergy symptoms like itching or hives by taking over-the-counter antihistamines such as diphenhydramine or cetirizine immediately after exposure. Apply cool compresses or calamine lotion to itchy skin to reduce discomfort and avoid scratching. However, if you experience any signs of a severe reaction like difficulty breathing, swelling of the throat or tongue, rapid heartbeat, or dizziness, you must use your epinephrine auto-injector immediately and call 911, as home remedies cannot treat anaphylaxis. Keep a food diary to track potential exposures and always have your emergency medications easily accessible.
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Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

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As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Allergy-Shellfish Panel
Google reviews 505 reviews
$193 $151
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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