Serotonin syndrome is a potentially life-threatening condition caused by excessive serotonin activity in the nervous system. It occurs when medications that increase serotonin levels interact or accumulate to dangerous concentrations in the body. The Serotonin, Serum test is the most important test for diagnosis because it directly measures serotonin levels in the blood to confirm the biochemical imbalance.
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Serotonin syndrome is caused by excessive accumulation of serotonin in the nervous system, typically from drug interactions or overdoses. Common culprits include selective serotonin reuptake inhibitors (SSRIs) like fluoxetine and sertraline, serotonin-norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs), pain medications like tramadol and fentanyl, migraine medications called triptans, and even supplements like St. John's wort. When these medications are combined or taken in excessive doses, serotonin levels build up to dangerous concentrations in the brain and body, triggering the syndrome.
The Serotonin, Serum test is the most important test for serotonin syndrome because it directly measures serotonin concentrations in your blood to confirm excessive serotonin activity. This test provides concrete evidence of the biochemical imbalance causing your symptoms and helps doctors monitor how well treatment is working. Additionally, medication-specific tests like the Tramadol and Metabolite test or the Dextro/Levo Methorphan test can identify whether specific drugs are contributing to dangerously high serotonin levels. These tests measure the actual concentrations of medications known to trigger serotonin syndrome, helping your healthcare provider determine which drug is the culprit and guide treatment decisions.
You should get tested if you are taking multiple medications that affect serotonin and develop symptoms like agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, muscle twitching or rigidity, heavy sweating, diarrhea, or fever. Get tested immediately if you recently started a new antidepressant, increased your dosage, or combined medications like SSRIs with pain medications, migraine drugs, or supplements. Testing is especially urgent if you experience severe symptoms like high fever above 104°F, seizures, irregular heartbeat, or loss of consciousness, as these indicate a medical emergency requiring immediate intervention.
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What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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