Question 1

What is Selective IgA deficiency?

Accepted Answer

Selective IgA deficiency is the most common primary immunodeficiency disorder characterized by low or absent immunoglobulin A antibodies. It is caused by a defect in the immune system that prevents B cells from producing adequate IgA while maintaining normal levels of IgG and IgM immunoglobulins. The IgG, IgA, Indirect Immunofluorescence test is the most important test for diagnosis because it directly measures IgA levels alongside other immunoglobulins to confirm the deficiency.

Question 2

What causes Selective IgA deficiency?

Accepted Answer

Selective IgA deficiency is caused by a defect in the maturation of B cells that prevents them from producing adequate immunoglobulin A antibodies. The exact genetic mechanisms are not fully understood, but the condition appears to involve a failure of B lymphocytes to switch from producing IgM to IgA antibodies. In most cases, the deficiency is sporadic, though some families show genetic patterns suggesting inherited factors that affect immune system development and antibody production.

Question 3

What is the best test for Selective IgA deficiency?

Accepted Answer

The IgG, IgA, Indirect Immunofluorescence test is the most important test for Selective IgA deficiency because it directly measures all major immunoglobulin levels in your blood. This test identifies low or absent IgA levels (typically below 7 mg/dL) while confirming that IgG and IgM levels remain normal, which is the hallmark of this condition. Additional tests like the Celiac Disease Comprehensive Panel may be recommended since people with IgA deficiency have higher rates of celiac disease and can get false-negative results on standard celiac tests. The Candida albicans antibody test can also help evaluate your immune response to fungal infections that commonly affect mucosal surfaces when IgA is deficient.

Question 4

When should I get tested for Selective IgA deficiency?

Accepted Answer

You should get tested if you experience frequent respiratory infections like sinusitis, ear infections, or bronchitis that keep coming back. Testing is also important if you have recurring digestive problems, chronic diarrhea, food allergies, or autoimmune conditions like celiac disease or rheumatoid arthritis. You should also consider testing if you have a family history of immunodeficiency disorders, unexplained allergic reactions, or if your doctor suspects an immune system problem based on your pattern of infections.

Question 5

What are the symptoms of Selective IgA deficiency?

Accepted Answer

Many people with Selective IgA deficiency have no symptoms at all and live normal, healthy lives. When symptoms do occur, they typically include recurrent sinus infections, ear infections, bronchitis, and pneumonia affecting the respiratory tract. You might also experience frequent gastrointestinal infections, chronic diarrhea, and digestive issues. Some people develop autoimmune conditions like celiac disease, rheumatoid arthritis, or lupus. Allergies and asthma are also more common in people with this deficiency, and some experience severe allergic reactions to blood products containing IgA.

Question 6

Who is at risk for Selective IgA deficiency?

Accepted Answer

Selective IgA deficiency affects approximately 1 in 700 people, making it the most common primary immunodeficiency disorder. It occurs equally in men and women and can affect people of all ethnicities, though it appears more frequently in individuals of European descent. People with family members who have IgA deficiency or common variable immunodeficiency are at higher risk. The condition can develop at any age but is often identified in childhood when recurrent infections begin or during routine blood work in adults.

Question 7

What happens if Selective IgA deficiency is left untreated?

Accepted Answer

If undiagnosed and unmanaged, Selective IgA deficiency can lead to chronic respiratory infections that may cause permanent lung damage and bronchiectasis over time. Repeated gastrointestinal infections can result in malabsorption, nutritional deficiencies, and chronic digestive problems. People with unrecognized IgA deficiency are at higher risk of developing autoimmune diseases and may experience severe, life-threatening allergic reactions if they receive blood transfusions containing IgA antibodies. Early diagnosis allows your healthcare provider to monitor for complications, provide prompt treatment for infections, and take necessary precautions during medical procedures requiring blood products.

Question 8

Can Selective IgA deficiency be diagnosed with a blood test?

Accepted Answer

Yes, Selective IgA deficiency is definitively diagnosed with a simple blood test that measures immunoglobulin levels. The IgG, IgA, Indirect Immunofluorescence test measures the concentrations of IgA, IgG, and IgM antibodies in your blood. A diagnosis is confirmed when IgA levels are below 7 mg/dL while IgG and IgM levels remain within normal ranges. This blood test requires no special preparation and provides clear results that help your healthcare provider determine if you have this immune deficiency and need specific medical management.

Question 9

How is Selective IgA deficiency treated?

Accepted Answer

There is no cure or specific treatment to replace missing IgA antibodies, but the condition can be effectively managed. Treatment focuses on promptly addressing infections with appropriate antibiotics when they occur. Your doctor may recommend preventive antibiotics if you experience frequent recurring infections. Vaccinations are important to prevent infections, though live vaccines may need special consideration. People with IgA deficiency should wear medical alert identification indicating they must receive washed red blood cells or IgA-deficient blood products to prevent severe allergic reactions during transfusions. Regular monitoring for autoimmune conditions and maintaining overall good health practices are essential components of long-term management.

Question 10

How can I prevent complications from Selective IgA deficiency?

Accepted Answer

You can reduce your risk of complications by practicing excellent hygiene, including frequent handwashing and avoiding close contact with people who are sick. Stay current with recommended vaccinations to prevent infections. Eat a balanced diet rich in fruits, vegetables, and whole foods to support your overall immune function. Get adequate sleep, manage stress, and exercise regularly to maintain general health. Inform all healthcare providers about your IgA deficiency before any procedures, surgeries, or blood transfusions. Seek prompt medical attention at the first sign of infection rather than waiting to see if symptoms resolve on their own.

Question 11

What can I do at home to manage Selective IgA deficiency?

Accepted Answer

At home, focus on maintaining a healthy lifestyle that supports your immune system. Eat a nutrient-rich diet with plenty of vitamin C, vitamin D, zinc, and probiotics to support gut and immune health. Use a humidifier to keep airways moist and reduce respiratory irritation. Practice nasal rinsing with saline solution to help prevent sinus infections. Stay well-hydrated and get 7-9 hours of quality sleep each night. Avoid smoking and limit alcohol consumption, as both can weaken immune function. Keep a symptom diary to track infections and identify patterns that can help you and your doctor manage your condition more effectively.

Question 12

How’s this work?

Accepted Answer

Getting your blood test with us is easy, private & backed by the power of science.Long story short:
            
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Question 13

How do I know which test to get?

Accepted Answer

In the test options, find the test you want.
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Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
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Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

Absolutely! We totally understand that errors can happen. No worries, we're here to help you.
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Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
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Question 17

Can I cancel my order?

Accepted Answer

Yes.
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Question 18

How can I find a lab location near me?

Accepted Answer

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached!
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Selective IgA Deficiency Blood Test

What is Selective IgA deficiency?

What causes Selective IgA deficiency?

What is the best test for Selective IgA deficiency?

When should I get tested for Selective IgA deficiency?

References

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