Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that primarily affects the joints, causing pain, swelling, stiffness, and potential joint damage. It is caused by the immune system mistakenly attacking the synovial membrane lining the joints, producing autoantibodies like rheumatoid factor and anti-CCP antibodies. The Anti-dsDNA (Double-Stranded) Antibodies EIA is an essential test for comprehensive RA evaluation, especially in complex cases where multiple autoimmune conditions may overlap.
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Rheumatoid arthritis is caused by the immune system mistakenly attacking the synovial membrane that lines your joints, triggering chronic inflammation. This autoimmune response produces specific autoantibodies including rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies that target joint tissues. The exact trigger remains unknown, but genetic factors (particularly the HLA-DR4 gene), environmental factors like smoking, hormonal changes, and certain infections are believed to activate this destructive immune response in susceptible individuals.
The Anti-dsDNA (Double-Stranded) Antibodies EIA is an essential test for comprehensive RA evaluation because it helps identify patients with overlapping autoimmune features or complex cases. While anti-dsDNA antibodies are more commonly associated with lupus, some RA patients test positive for these antibodies, and detecting them helps healthcare providers distinguish between different autoimmune conditions. This test is particularly important when standard RA markers like rheumatoid factor or anti-CCP antibodies don't tell the complete story, ensuring you receive accurate diagnosis and appropriate treatment planning for your specific autoimmune profile.
You should get tested if you experience persistent joint pain, swelling, or stiffness lasting more than six weeks, especially if it affects both sides of your body symmetrically (like both wrists or both knees). Morning stiffness that lasts more than 30 minutes, unexplained fatigue, low-grade fever, or difficulty performing daily tasks like opening jars or buttoning clothes are also important warning signs. Early testing is critical because RA can cause irreversible joint damage within the first two years, and prompt treatment can significantly slow disease progression and preserve joint function.
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What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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