Retinitis Blood Test

What is Retinitis?

Retinitis is inflammation of the retina, the light-sensitive tissue at the back of the eye that enables vision. It is caused by viral infections such as cytomegalovirus (CMV), particularly in immunocompromised individuals with HIV/AIDS or those receiving immunosuppressive therapy. The Cytomegalovirus (CMV) Antibodies IgG test is the most important test for identifying CMV infection that can lead to retinitis.

RECOMMENDED TEST Cytomegalovirus (CMV) Antibodies, IgG
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What causes retinitis?

Retinitis is caused by viral infections, with cytomegalovirus (CMV) being the most common culprit in people with weakened immune systems. Other infectious causes include herpes simplex virus (HSV), varicella-zoster virus (VZV), and toxoplasmosis. In immunocompromised individuals such as those with HIV/AIDS, organ transplant recipients, or patients on immunosuppressive medications, these viruses can activate and attack the retina, leading to inflammation and potential vision loss. The infection damages the light-sensitive retinal tissue, causing blind spots and progressive vision problems if left untreated.

What is the best test for retinitis?

The Cytomegalovirus (CMV) Antibodies IgG test is the most important blood test for retinitis because it detects antibodies against CMV, the primary infectious cause of retinitis in immunocompromised patients. This test identifies whether you have been exposed to CMV and helps assess your risk for developing CMV retinitis, especially if you have a weakened immune system. High levels of CMV IgG antibodies indicate past or current infection that could progress to sight-threatening retinitis. While the diagnosis of retinitis itself requires an eye examination by an ophthalmologist, blood testing for CMV is essential for identifying the underlying infection and guiding treatment decisions to prevent vision loss.

When should I get tested for retinitis?

You should get tested if you have a compromised immune system and experience vision changes such as floaters, blurred vision, blind spots, or flashing lights. Testing is particularly important for people living with HIV/AIDS, organ transplant recipients, cancer patients receiving chemotherapy, or anyone taking immunosuppressive medications. You should also consider testing if you have been diagnosed with CMV infection elsewhere in your body, as the virus can spread to the eyes. Early detection through blood testing allows for prompt treatment before permanent vision damage occurs.

What are the symptoms of retinitis?
Symptoms of retinitis include floaters (dark spots or cobwebs in your vision), blurred or decreased vision, blind spots in your visual field, flashing lights, and loss of peripheral vision. You might notice that objects appear distorted or that straight lines look wavy. In CMV retinitis, symptoms often start in one eye but can affect both eyes over time. Vision loss typically progresses gradually but can advance rapidly without treatment. Some people also experience eye pain or redness, though retinitis itself is often painless in the early stages.
Who is at risk for retinitis?
People with weakened immune systems are at highest risk for infectious retinitis, particularly CMV retinitis. This includes individuals with HIV/AIDS (especially those with CD4 counts below 50), organ transplant recipients taking anti-rejection medications, cancer patients undergoing chemotherapy, and people with autoimmune diseases on immunosuppressive therapy. Newborns can develop congenital CMV retinitis if their mothers have an active infection during pregnancy. Additionally, people with diabetes or other conditions affecting blood flow to the eye have increased risk for certain types of retinitis.
What happens if retinitis is left untreated?
Untreated retinitis leads to progressive and irreversible vision loss that can result in complete blindness. The infection causes permanent damage to the retina, creating expanding areas of dead tissue that cannot be restored even with later treatment. CMV retinitis can cause retinal detachment, a serious complication requiring emergency surgery. The infection may also spread from one eye to both eyes, doubling the impact on your vision. In immunocompromised patients, untreated CMV can also spread to other organs including the brain, lungs, and digestive system, causing life-threatening complications. Early detection and treatment are critical to preserving vision.
Can retinitis be diagnosed with a blood test?
Blood tests cannot directly diagnose retinitis itself, as the condition is diagnosed through a comprehensive eye examination by an ophthalmologist using specialized imaging and dilated fundus examination. However, blood tests play a crucial role in identifying the underlying infectious causes of retinitis, particularly CMV infection. The CMV Antibodies IgG test detects exposure to cytomegalovirus and helps assess risk for developing CMV retinitis in immunocompromised patients. Blood tests also help monitor immune system function and can detect other infections that may cause retinitis, making them an essential part of the diagnostic process alongside eye examinations.
How is retinitis treated?
Retinitis treatment focuses on controlling the underlying infection with antiviral medications. For CMV retinitis, doctors prescribe antiviral drugs such as ganciclovir, foscarnet, or cidofovir, which can be given intravenously, orally, or through injections directly into the eye. Treatment typically continues long-term to prevent recurrence, especially in immunocompromised patients. In addition to antivirals, improving immune system function is critical, such as through antiretroviral therapy for HIV patients or adjusting immunosuppressive medications in transplant recipients. Regular eye examinations are necessary to monitor treatment effectiveness and detect any progression of retinal damage. In cases of retinal detachment, surgical intervention may be required.
How can I prevent retinitis?
Prevention focuses on maintaining a healthy immune system and avoiding infection. If you have HIV, taking antiretroviral therapy consistently to keep your viral load low and CD4 count high is the most effective prevention strategy. People at high risk may receive prophylactic antiviral medications to prevent CMV infection. Practice good hygiene including frequent handwashing, avoid contact with bodily fluids from people who may have CMV, and be cautious around young children who commonly carry CMV. If you are immunocompromised, attend regular medical appointments for monitoring and get blood tests to detect infections early before they affect your eyes. Pregnant women should take precautions to avoid CMV infection to prevent congenital retinitis in their babies.
What can I do at home for retinitis?
While retinitis requires medical treatment and cannot be managed at home alone, you can support your eye health and overall immune function through healthy lifestyle choices. Eat a nutrient-rich diet with plenty of vitamins A, C, and E, which support eye health and immune function. Take all prescribed antiviral medications exactly as directed without missing doses. Monitor your vision daily and report any changes to your doctor immediately. Protect your eyes from UV damage by wearing sunglasses outdoors. Get adequate sleep, manage stress, and avoid smoking, which weakens immune function. Keep all scheduled appointments with your eye doctor and infectious disease specialist for ongoing monitoring. If you have HIV, adherence to antiretroviral therapy is critical for preventing CMV reactivation.
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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Cytomegalovirus (CMV) Antibodies, IgG
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
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No extra fees paid at the lab

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