Restless Legs Syndrome (RLS) is a neurological condition characterized by an irresistible urge to move the legs, typically during rest or sleep. It is caused by low iron levels in the brain, which disrupts dopamine pathways involved in movement control. The Ferritin, Serum test is the most important test for diagnosis because it measures iron stores that directly affect RLS symptoms.
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Restless Legs Syndrome is caused by low iron levels in the brain that disrupt dopamine pathways responsible for controlling movement. Iron plays a critical role in dopamine production, and when brain iron stores are depleted, it affects the neurotransmitter systems that regulate motor control. This iron-dopamine connection explains why many people with RLS experience symptoms that worsen during periods of rest or inactivity, particularly in the evening and nighttime hours.
The Ferritin, Serum test is the most important test for Restless Legs Syndrome because it measures your body's iron stores, which directly impact RLS symptoms. Low ferritin levels are strongly associated with RLS, and identifying iron deficiency can guide effective treatment strategies. Many people with RLS who correct their iron deficiency through supplementation experience significant symptom improvement. While RLS is primarily diagnosed through clinical evaluation of your symptoms, ferritin testing helps identify the underlying iron deficiency that contributes to the condition and can be treated.
You should get tested if you experience an uncomfortable urge to move your legs that worsens during rest or at night, disrupts your sleep regularly, or causes daytime fatigue and difficulty concentrating. Testing is especially important if you have symptoms at least twice a week, notice that movement temporarily relieves the sensations, or have a family history of RLS. Early testing can identify iron deficiency and help you start treatment before the condition significantly impacts your quality of life and sleep.
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What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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