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Renal disease is a progressive condition where the kidneys lose their ability to filter waste products and excess fluid from the blood. It is caused by damage to the nephrons (filtering units) from diabetes, high blood pressure, infections, or autoimmune disorders. The Kidney Function Profile is the most important test for diagnosis because it measures BUN, creatinine, and the BUN to creatinine ratio to assess how well your kidneys are filtering waste.
Renal disease is caused by damage to the nephrons, which are the tiny filtering units inside your kidneys. The most common causes include uncontrolled diabetes, which damages blood vessels in the kidneys through high blood sugar levels, and chronic high blood pressure, which puts excessive strain on the delicate kidney filters. Other causes include glomerulonephritis (inflammation of the kidney filters), polycystic kidney disease (a genetic condition causing cysts), recurrent kidney infections, autoimmune diseases like lupus, and prolonged use of certain medications like NSAIDs. Once the nephrons are damaged, they cannot regenerate, which is why early detection is critical.
The Kidney Function Profile is the most important test for renal disease because it measures three critical markers that reveal how well your kidneys are filtering waste. Blood urea nitrogen (BUN) shows whether waste products are accumulating in your blood instead of being removed by the kidneys. Creatinine is a waste product from muscle breakdown that healthy kidneys filter out efficiently, so elevated levels indicate kidney damage. The BUN to creatinine ratio helps doctors determine whether kidney problems are caused by dehydration, kidney damage, or other issues. Together, these markers provide a comprehensive picture of kidney function and help identify disease in its early stages before symptoms appear.
You should get tested if you have diabetes or high blood pressure, as these are the leading causes of kidney damage. Other reasons to test include a family history of kidney disease, frequent urinary tract infections, foamy or bloody urine, swelling in your ankles or feet, persistent fatigue, or difficulty concentrating. People over 60, those with heart disease, and anyone taking medications that can affect kidney function should also consider regular testing. Since kidney disease often has no symptoms in early stages, testing is especially important for those with risk factors, as early detection can slow or prevent progression to kidney failure.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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