Pulmonary embolism is a life-threatening condition where a blood clot blocks one of the pulmonary arteries in the lungs. It is caused by blood clots that typically form in the deep veins of the legs and travel to the lungs, often due to genetic clotting disorders like Factor V Leiden mutation. The Factor V Leiden Mutation Analysis is the most important test for assessing inherited clotting risk and preventing future pulmonary embolism episodes.
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Pulmonary embolism is caused by blood clots that form in the deep veins of the legs (deep vein thrombosis) and break loose to travel through the bloodstream to the lungs. These clots block pulmonary arteries, preventing oxygen-rich blood from reaching lung tissue. Risk factors include genetic clotting disorders like Factor V Leiden mutation, prolonged immobility during long flights or bed rest, recent surgery, pregnancy, birth control pills, smoking, cancer, and inherited blood clotting conditions that create a hypercoagulable state in the body.
The Factor V Leiden Mutation Analysis is the most important blood test for assessing inherited pulmonary embolism risk because it detects the most common genetic clotting disorder that predisposes people to developing blood clots. This genetic test identifies whether you carry the Factor V Leiden mutation, which creates a hypercoagulable state and significantly increases your likelihood of forming dangerous blood clots that can travel to the lungs. While pulmonary embolism itself is diagnosed through imaging studies like CT angiography, the Factor V Leiden test is essential for understanding your underlying genetic risk, guiding long-term prevention strategies, and determining appropriate anticoagulation therapy duration after a PE event.
You should get tested if you have experienced an unexplained blood clot or pulmonary embolism, especially at a young age (under 50). Testing is also important if you have a family history of blood clots or pulmonary embolism, have had recurrent clotting episodes, or are planning pregnancy or starting birth control pills and have clotting concerns. Get tested before major surgery if you have a personal or family history of abnormal clotting, or if you have experienced a blood clot during pregnancy or while taking hormonal medications.
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What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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