Polycythemia Blood Test

What is Polycythemia?

Polycythemia is a blood disorder characterized by an abnormally high number of red blood cells in the bloodstream, which increases blood viscosity and raises the risk of blood clots, stroke, and heart attack. It can be caused by bone marrow disorders like polycythemia vera, low oxygen levels from lung disease or high altitude, kidney disease, or elevated testosterone levels. The Complete Blood Count (CBC) is the most important test for diagnosing polycythemia because it measures red blood cell count, hemoglobin, and hematocrit levels.

RECOMMENDED TEST Complete Blood Count / CBC (includes Differential and Platelets)
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What causes polycythemia?

Polycythemia is caused by either bone marrow disorders like polycythemia vera, where the bone marrow produces too many red blood cells spontaneously, or secondary factors that trigger increased red blood cell production. Secondary causes include chronic low oxygen levels from lung disease, sleep apnea, or living at high altitude, kidney disease that produces excess erythropoietin hormone, elevated testosterone levels in men, or certain tumors that secrete hormones stimulating red blood cell production. The primary form, polycythemia vera, is a myeloproliferative disorder caused by genetic mutations in blood-forming cells.

What is the best test for polycythemia?

The Complete Blood Count (CBC) is the most important test for polycythemia because it measures the three key indicators of the condition: red blood cell count, hemoglobin levels, and hematocrit percentage. Elevated values in these parameters directly indicate that your body is producing too many red blood cells. For male patients, the Testosterone Total test is essential because high testosterone can stimulate excess red blood cell production and identify a treatable hormonal cause. The Sedimentation Rate test provides additional diagnostic support by showing how polycythemia affects blood viscosity and can help monitor disease progression over time.

When should I get tested for polycythemia?

You should get tested if you experience symptoms like persistent headaches, dizziness, vision problems, or redness in your face and hands. Testing is also important if you have unexplained itching after showering or bathing, frequent bleeding or bruising, or if routine blood work shows elevated red blood cell counts. Men using testosterone replacement therapy should be tested regularly to monitor for polycythemia development. Additionally, if you have risk factors like chronic lung disease, sleep apnea, smoking history, or kidney problems, screening blood tests can detect the condition before serious complications like blood clots or stroke occur.

What are the symptoms of polycythemia?
Polycythemia symptoms include headaches, dizziness, blurred or double vision, and redness or flushing in the face, particularly in the cheeks and nose. You might experience unexplained itching, especially after taking a warm bath or shower, which is caused by the release of histamine. Other symptoms include fatigue, weakness, shortness of breath, ringing in the ears, excessive sweating, and a feeling of fullness in the left upper abdomen due to an enlarged spleen. Some people develop easy bruising or bleeding, joint pain, and numbness or tingling in the hands and feet due to poor circulation from thickened blood.
Who is at risk for polycythemia?
People over age 60 are at higher risk for polycythemia vera, with men slightly more affected than women. Those with chronic lung diseases like COPD, emphysema, or chronic bronchitis face increased risk due to persistent low oxygen levels. Smokers have elevated risk because carbon monoxide reduces oxygen delivery to tissues, triggering red blood cell overproduction. People living at high altitudes, men taking testosterone therapy or anabolic steroids, individuals with sleep apnea causing nighttime oxygen drops, and those with kidney disease or certain tumors producing excess erythropoietin are also at higher risk. Family history of polycythemia vera increases your likelihood of developing the condition.
What happens if polycythemia is left untreated?
Untreated polycythemia significantly increases your risk of life-threatening blood clots that can cause deep vein thrombosis, pulmonary embolism, heart attack, or stroke. The thickened blood strains your heart and can lead to heart failure over time. You face higher risk of bleeding complications despite having more blood cells, because the excessive cells interfere with normal clotting function. Your spleen can become dangerously enlarged trying to filter the excess blood cells, potentially rupturing. Untreated polycythemia vera can transform into acute leukemia or myelofibrosis, serious bone marrow disorders with poor outcomes. Chronic symptoms like severe itching, fatigue, and joint pain significantly reduce quality of life when left unmanaged.
Can polycythemia be diagnosed with a blood test?
Yes, polycythemia is diagnosed primarily through blood tests, making it one of the most straightforward blood disorders to detect. The Complete Blood Count measures red blood cell count, hemoglobin, and hematocrit, with elevated values in all three indicating polycythemia. For men, hemoglobin above 16.5 g/dL or hematocrit above 49 percent, and for women, hemoglobin above 16.0 g/dL or hematocrit above 48 percent typically indicate the condition. Additional blood tests may include erythropoietin levels to determine if polycythemia is primary or secondary, genetic testing for JAK2 mutation in suspected polycythemia vera, and oxygen saturation levels to identify low oxygen as a cause.
How is polycythemia treated?
Polycythemia treatment focuses on reducing red blood cell counts and preventing blood clots. Phlebotomy, or therapeutic blood removal similar to blood donation, is the primary treatment, removing blood regularly until hematocrit reaches safe levels. Low-dose aspirin is commonly prescribed to reduce clotting risk. For polycythemia vera, medications like hydroxyurea can slow bone marrow red blood cell production. Secondary polycythemia requires treating the underlying cause, such as managing lung disease, addressing sleep apnea with CPAP therapy, or adjusting testosterone dosage in men on hormone therapy. Some patients need medications to control symptoms like antihistamines for itching or allopurinol to manage elevated uric acid levels.
How can I prevent polycythemia?
While you cannot prevent primary polycythemia vera caused by genetic mutations, you can reduce your risk of secondary polycythemia through lifestyle modifications. Quit smoking to improve oxygen delivery and prevent chronic lung disease. Maintain a healthy weight and treat sleep apnea to ensure adequate nighttime oxygen levels. If you take testosterone therapy, work with your doctor to use the lowest effective dose and monitor blood counts regularly. Stay well-hydrated to help maintain normal blood viscosity. Avoid unnecessary time at high altitudes if you are at risk. Regular health screenings can detect early changes in blood counts, allowing intervention before complications develop.
What can I do at home for polycythemia?
At home, stay well-hydrated by drinking plenty of water throughout the day to help thin your blood and improve circulation. Avoid very hot baths or showers that can trigger intense itching, opting instead for lukewarm water. Apply cool compresses or use cooling lotions to relieve itching without scratching. Exercise regularly with moderate activity like walking or swimming to improve circulation and reduce clotting risk, but avoid activities with high injury risk. Elevate your legs when sitting to prevent blood pooling. Avoid iron supplements unless specifically prescribed, as iron can worsen polycythemia. Wear compression stockings if recommended by your doctor to prevent blood clots in your legs, and attend all scheduled blood removal appointments to maintain safe blood counts.
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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.

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* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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