Pleural Effusion Blood Test

What is Pleural Effusions?

Pleural effusion is the abnormal accumulation of excess fluid in the pleural space between the lungs and chest cavity. It is caused by conditions including congestive heart failure, pneumonia, cancer (particularly lung and ovarian cancer), pulmonary embolism, kidney disease, and liver cirrhosis. The CA-125 blood test is the most important test for identifying cancer-related pleural effusions, especially when malignancy is suspected.

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What causes pleural effusion?

Pleural effusion is caused by congestive heart failure, pneumonia, cancer (lung, breast, ovarian, and lymphoma), pulmonary embolism, kidney disease, and liver cirrhosis. Heart failure causes fluid to back up into the pleural space, while infections like pneumonia trigger inflammatory fluid accumulation. Cancer cells can block lymphatic drainage or directly produce fluid, and kidney or liver disease disrupts the body's fluid balance, leading to excess accumulation around the lungs.

What is the best test for pleural effusion?

The CA-125 blood test is the most important test for identifying cancer-related pleural effusions because it detects elevated tumor marker levels associated with ovarian cancer and other malignancies that commonly cause fluid buildup. When CA-125 levels are elevated in the presence of pleural effusion, it signals the need for further cancer investigation. While imaging like chest X-rays and CT scans directly visualize the fluid, blood tests like CA-125 help identify the underlying cause, particularly when malignancy is suspected. Additional blood work may include complete blood count, kidney and liver function tests, and other markers to evaluate heart failure, infection, or inflammatory conditions.

When should I get tested for pleural effusion?

You should get tested if you experience shortness of breath, chest pain that worsens with deep breathing or coughing, persistent dry cough, or difficulty breathing when lying flat. Get evaluated immediately if you have fever with breathing difficulties, unexplained weight loss along with respiratory symptoms, or known cancer with new breathing problems. Early testing helps identify the underlying cause and prevents complications like lung collapse or respiratory failure.

What are the symptoms of pleural effusion?
Symptoms of pleural effusion include shortness of breath, sharp chest pain that worsens with deep breathing or coughing, dry persistent cough, and difficulty breathing when lying down. You might notice decreased exercise tolerance, rapid shallow breathing, and feeling like you cannot take a full breath. Large effusions can cause significant breathing difficulty and a feeling of heaviness in the chest, while small effusions may produce minimal or no symptoms.
Who is at risk for pleural effusion?
People at risk include those with congestive heart failure, pneumonia or lung infections, cancer (especially lung, breast, and ovarian), kidney disease, liver cirrhosis, and those who have recently had chest surgery or trauma. Individuals with autoimmune diseases like lupus or rheumatoid arthritis, those with pulmonary embolism history, and people undergoing cancer treatment are also at increased risk. Older adults and those with multiple chronic conditions face higher risk for developing pleural effusions.
What happens if pleural effusion is left untreated?
Untreated pleural effusion can cause lung collapse, severe respiratory failure, and life-threatening breathing difficulties. The accumulated fluid compresses lung tissue, reducing oxygen exchange and forcing the heart to work harder, potentially leading to heart strain. Infected pleural effusions can develop into empyema, a serious condition requiring surgical drainage, while cancer-related effusions may indicate disease progression. Chronic untreated effusions can cause permanent lung scarring and reduced lung capacity.
Can pleural effusion be diagnosed with a blood test?
Pleural effusion cannot be directly diagnosed with a blood test alone, but blood work plays a crucial role in identifying the underlying cause. The CA-125 test helps detect cancer-related effusions, while complete blood count identifies infections, and kidney and liver function tests reveal organ dysfunction causing fluid accumulation. Blood tests for heart failure markers like BNP, inflammatory markers, and albumin levels provide additional diagnostic information. Definitive diagnosis requires imaging like chest X-ray or ultrasound, often followed by thoracentesis to analyze the fluid directly.
How is pleural effusion treated?
Pleural effusion treatment depends on the underlying cause. Thoracentesis removes excess fluid to relieve breathing difficulties, while diuretics help eliminate fluid in heart failure or kidney disease cases. Cancer-related effusions may require chemotherapy, pleurodesis (sealing the pleural space), or catheter placement for ongoing drainage. Infections are treated with antibiotics, and some cases require chest tube insertion or surgery to drain persistent fluid. Treating the root cause, whether heart disease, infection, or cancer, is essential for preventing fluid reaccumulation.
How can I prevent pleural effusion?
Preventing pleural effusion involves managing underlying conditions like heart failure, kidney disease, and liver disease through medication adherence and lifestyle modifications. Promptly treat respiratory infections to prevent pneumonia-related effusions, and maintain regular cancer screenings if you have risk factors. Control blood pressure and diabetes to protect heart and kidney function, avoid smoking to reduce lung cancer risk, and limit alcohol consumption to protect liver health. Regular medical checkups help detect and manage conditions that could lead to fluid accumulation.
What can I do at home for pleural effusion?
At home, elevate your head while sleeping using multiple pillows to ease breathing, and rest in a semi-upright position to reduce lung compression. Practice controlled breathing exercises to maximize lung capacity, and monitor your symptoms including breathing difficulty, chest pain, and fever. Limit salt intake to reduce fluid retention, stay hydrated, and avoid strenuous activities that worsen breathlessness. However, pleural effusion requires medical evaluation and treatment, so home measures should complement, not replace, professional medical care. Seek immediate attention if symptoms worsen or you develop severe breathing difficulty.
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Long story short:
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  8. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

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Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
Can I cancel my order?
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We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
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During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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CA-125 (Ovarian Cancer Test)
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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