Peptic Ulcer Blood Test

What is Peptic Ulcer?

Peptic ulcers are open sores that develop on the inner lining of the stomach or upper portion of the small intestine (duodenum). They are caused by Helicobacter pylori bacterial infection or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) that damage the protective mucus layer. The H. Pylori Antigen Stool test is the most important test for diagnosis because it directly detects active H. pylori infection.

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What causes peptic ulcers?

Peptic ulcers are caused primarily by Helicobacter pylori bacterial infection and long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen. H. pylori bacteria weaken the protective mucus coating of the stomach and small intestine, allowing digestive acid to irritate the lining and create open sores. NSAIDs reduce the production of prostaglandins that help protect the stomach lining from acid damage. Other contributing factors include excessive alcohol consumption, smoking, and stress, which can increase stomach acid production and make the digestive tract more vulnerable to ulcer formation.

What is the best test for peptic ulcers?

The H. Pylori Antigen Stool test is the most important test for peptic ulcers because it directly detects active Helicobacter pylori infection, which causes approximately 60-90% of all peptic ulcers. This test identifies H. pylori antigens in your stool, confirming whether the bacteria is present and actively causing inflammation in your stomach or duodenal lining. For monitoring complications, the Amylase and Lipase blood tests are essential because they detect elevated pancreatic enzymes that signal serious complications like perforation or pancreatic involvement. These tests together provide a comprehensive assessment of both the underlying bacterial cause and potential complications requiring immediate medical intervention.

When should I get tested for peptic ulcers?

You should get tested if you experience burning stomach pain that comes and goes, especially between meals or at night, or if pain temporarily improves after eating or taking antacids. Other warning signs include unexplained weight loss, persistent nausea or vomiting, black or tarry stools indicating bleeding, or vomiting blood or material that looks like coffee grounds. Get tested immediately if you have severe, sudden abdominal pain that doesn't go away, as this could indicate a perforated ulcer requiring emergency care. Testing is also recommended if you regularly use NSAIDs or have a history of ulcers and notice symptoms returning.

What are the symptoms of peptic ulcers?
The most common symptom is burning stomach pain that feels like gnawing or hunger, typically occurring between meals when your stomach is empty and sometimes waking you up at night. You might notice the pain temporarily improves after eating or taking antacids, only to return a few hours later. Other symptoms include bloating, belching, heartburn, nausea, and feeling uncomfortably full after eating small amounts. In severe cases, you may experience vomiting, dark or black stools indicating bleeding, unexplained weight loss, or vomiting blood. Some people with peptic ulcers have no symptoms at all, especially in the early stages.
Who is at risk for peptic ulcers?
People who regularly take NSAIDs like aspirin, ibuprofen, or naproxen for chronic pain or arthritis are at higher risk because these medications reduce the stomach's protective mucus layer. Those infected with Helicobacter pylori bacteria, which spreads through contaminated food, water, or close contact with infected individuals, have significantly increased risk. Heavy alcohol drinkers and smokers face elevated risk because these habits increase stomach acid production and interfere with healing. People over 50, those with a family history of ulcers, and individuals experiencing frequent stress also have higher susceptibility to developing peptic ulcers.
What happens if peptic ulcers are left untreated?
Untreated peptic ulcers can lead to serious, life-threatening complications requiring emergency medical care. The ulcer can perforate through the stomach or intestinal wall, causing stomach contents to leak into the abdominal cavity and resulting in peritonitis, a severe infection. Ulcers can erode into blood vessels causing internal bleeding, which appears as black, tarry stools or vomiting blood, potentially leading to severe anemia or shock. Chronic ulcers can cause scarring that narrows or blocks the digestive tract, preventing food from passing through properly and causing persistent vomiting and weight loss. Early testing and treatment prevent these dangerous complications and promote complete healing.
Can peptic ulcers be diagnosed with a blood test?
Blood tests alone cannot definitively diagnose peptic ulcers, but they play a crucial role in identifying the underlying cause and monitoring complications. The H. Pylori Antigen Stool test detects active Helicobacter pylori infection, the primary bacterial cause of most peptic ulcers. Blood tests measuring amylase and lipase levels help identify serious complications like perforation or pancreatic involvement that require immediate attention. A complete blood count may reveal anemia from chronic bleeding ulcers. While endoscopy remains the gold standard for visualizing ulcers directly, blood tests provide essential information about the cause and help healthcare providers determine the most appropriate treatment approach and monitor your response to therapy.
How is a peptic ulcer treated?
Treatment depends on the underlying cause identified through testing. If H. pylori infection is detected, your doctor will prescribe a combination of antibiotics along with proton pump inhibitors (PPIs) to reduce stomach acid and allow healing, typically for 10-14 days. For ulcers caused by NSAIDs, stopping or reducing these medications and taking acid-reducing medications like PPIs or H2 blockers helps the ulcer heal over 4-8 weeks. Antacids provide quick symptom relief by neutralizing stomach acid. Lifestyle modifications including avoiding alcohol, quitting smoking, managing stress, and eating smaller, more frequent meals support healing. Most peptic ulcers heal completely with proper treatment, though follow-up testing ensures the infection is cleared and healing is complete.
How can I prevent peptic ulcers?
Prevent peptic ulcers by practicing good hygiene to avoid H. pylori infection, including washing hands thoroughly before eating and after using the bathroom, and consuming properly prepared food and clean water. If you need NSAIDs regularly for chronic pain, take the lowest effective dose with food, or ask your doctor about protective medications like proton pump inhibitors. Limit or avoid alcohol consumption and quit smoking, as both increase stomach acid and interfere with the protective mucus layer. Manage stress through relaxation techniques, regular exercise, and adequate sleep, as chronic stress contributes to increased acid production. Eating a balanced diet with regular meals and avoiding foods that trigger symptoms helps maintain a healthy digestive system.
What natural remedies help with peptic ulcers?
While natural remedies should complement rather than replace medical treatment, several approaches may support ulcer healing and symptom relief. Probiotics containing beneficial bacteria can help fight H. pylori infection and restore healthy gut balance when taken alongside antibiotics. Honey, particularly manuka honey, has antibacterial properties that may help combat H. pylori. Flavonoid-rich foods like apples, berries, celery, and green tea have protective effects on the stomach lining and may reduce ulcer formation. Deglycyrrhizinated licorice (DGL) may help increase mucus production to protect the stomach. Avoid spicy foods, caffeine, and acidic foods if they worsen your symptoms. Always consult your healthcare provider before using natural remedies, especially if you're taking medications, as some supplements can interfere with treatment.
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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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H. Pylori Antigen Stool
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No need to visit a doctor
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