Question 1

What is Ovarian Failure?

Accepted Answer

Ovarian failure, also known as primary ovarian insufficiency (POI), occurs when the ovaries stop functioning normally before age 40. It is caused by decreased production of estradiol and other hormones due to premature loss of ovarian follicles. The Estradiol blood test is the most important test for diagnosis because it directly measures the primary hormone produced by the ovaries.

Question 2

What causes ovarian failure?

Accepted Answer

Ovarian failure is caused by premature depletion of ovarian follicles, which are the structures in the ovaries that contain eggs and produce hormones like estradiol. This depletion can result from genetic conditions like Turner syndrome or Fragile X syndrome, autoimmune disorders where the body attacks ovarian tissue, chemotherapy or radiation therapy, surgical removal of ovaries, or unknown factors in many cases. When the follicles are depleted or damaged, the ovaries can no longer produce adequate levels of estradiol and other reproductive hormones, leading to irregular periods, infertility, and early menopause symptoms before age 40.

Question 3

What is the best test for ovarian failure?

Accepted Answer

The Estradiol blood test is the most important test for ovarian failure because it directly measures the primary hormone produced by the ovaries. When ovarian function declines, estradiol levels drop significantly, which explains symptoms like missed periods, hot flashes, and infertility. Low estradiol levels combined with elevated FSH (follicle-stimulating hormone) levels confirm the diagnosis. The Estradiol test is essential because it provides clear evidence of reduced ovarian hormone production and helps distinguish ovarian failure from other causes of irregular periods. Your doctor may also order additional hormone tests including FSH and LH to get a complete picture of ovarian function.

Question 4

When should I get tested for ovarian failure?

Accepted Answer

You should get tested if you are under 40 years old and experience irregular or missed periods for three or more months, have difficulty getting pregnant despite regular unprotected intercourse, notice hot flashes or night sweats similar to menopause symptoms, experience vaginal dryness or decreased sex drive, or have a family history of early menopause or ovarian failure. Getting tested early is important because early diagnosis allows for timely treatment to manage symptoms, protect bone health, and preserve fertility options. If you have received chemotherapy or radiation, have an autoimmune condition, or carry genetic risk factors like Fragile X premutation, you should get tested even before symptoms appear.

Question 5

What are the symptoms of ovarian failure?

Accepted Answer

Symptoms of ovarian failure include irregular or absent menstrual periods, hot flashes and night sweats, vaginal dryness and discomfort during intercourse, decreased sex drive, difficulty concentrating or mood changes, and trouble getting pregnant. Many women also experience sleep disturbances, fatigue, and irritability similar to menopause symptoms. These symptoms occur because the ovaries are not producing enough estradiol and other hormones. The severity of symptoms varies from woman to woman, and some may have minimal symptoms while others experience significant disruption to their daily lives.

Question 6

Who is at risk for ovarian failure?

Accepted Answer

Women with certain genetic conditions like Turner syndrome, Fragile X premutation, or a family history of early menopause are at higher risk for ovarian failure. Those who have undergone chemotherapy, radiation therapy, or pelvic surgery are also at increased risk. Autoimmune disorders such as thyroid disease, Addison disease, or rheumatoid arthritis can trigger the immune system to attack ovarian tissue. Women with unexplained infertility or irregular periods in their 20s or 30s may have undiagnosed ovarian failure. Smoking and certain viral infections may also increase risk, though many cases occur without any identifiable risk factors.

Question 7

What happens if ovarian failure is left untreated?

Accepted Answer

Untreated ovarian failure leads to progressive bone loss and increased risk of osteoporosis because low estradiol levels weaken bones. Women with untreated ovarian failure also face higher risk of heart disease since estradiol helps protect cardiovascular health. Infertility becomes permanent if not addressed early, and symptoms like hot flashes, vaginal dryness, and mood changes can significantly affect quality of life. Low estrogen levels also increase risk of cognitive decline and may contribute to depression and anxiety. Early diagnosis and hormone replacement therapy can prevent or minimize these complications and help maintain overall health and well-being.

Question 8

Can ovarian failure be diagnosed with a blood test?

Accepted Answer

Yes, ovarian failure can be diagnosed with blood tests that measure hormone levels. The Estradiol blood test is the primary test used to detect low levels of this key ovarian hormone. Doctors typically also order FSH (follicle-stimulating hormone) and LH (luteinizing hormone) tests, which become elevated when the ovaries fail to respond properly. Blood tests are the most accurate way to confirm ovarian failure because they directly measure the hormones affected by this condition. These tests are usually repeated on different days of your menstrual cycle to confirm the diagnosis, and your doctor will interpret results alongside your symptoms and medical history.

Question 9

How is ovarian failure treated?

Accepted Answer

Ovarian failure is primarily treated with hormone replacement therapy (HRT) that provides estradiol and progesterone to replace what the ovaries no longer produce. HRT helps relieve symptoms like hot flashes and vaginal dryness, protects bone health, and reduces heart disease risk. Women who wish to become pregnant may consider fertility treatments like egg donation or embryo donation since their own eggs are unlikely to be viable. Calcium and vitamin D supplements are recommended to support bone health, and lifestyle modifications like regular exercise and a healthy diet are important. Treatment is typically continued until the natural age of menopause (around age 50) to prevent long-term health complications.

Question 10

How can I prevent ovarian failure?

Accepted Answer

While many cases of ovarian failure cannot be prevented, especially those caused by genetic factors, you can reduce your risk by avoiding smoking, which accelerates ovarian aging. If you need chemotherapy or radiation therapy, discuss fertility preservation options like egg or ovarian tissue freezing with your doctor beforehand. Managing autoimmune conditions properly may help reduce the risk of immune-related ovarian damage. Maintaining a healthy weight, exercising regularly, and eating a balanced diet support overall reproductive health. If you have a family history of early menopause or carry genetic risk factors, talk to your doctor about early screening and monitoring to catch ovarian failure in its earliest stages.

Question 11

What natural remedies help with ovarian failure?

Accepted Answer

While natural remedies cannot restore ovarian function, certain approaches can help manage symptoms and support overall health. Phytoestrogens found in soy products, flaxseeds, and legumes may help reduce hot flashes in some women. Regular weight-bearing exercise like walking, jogging, or strength training helps maintain bone density and reduces osteoporosis risk. Stress reduction techniques such as yoga, meditation, or deep breathing can improve mood and sleep quality. Adequate calcium and vitamin D intake through diet or supplements supports bone health. However, these natural approaches should complement, not replace, medical treatment with hormone replacement therapy, which is essential for preventing long-term complications and managing symptoms effectively.

Question 12

How’s this work?

Accepted Answer

Getting your blood test with us is easy, private & backed by the power of science.Long story short:
            
                In the test options, use the filters or search box to narrow your choices and find the test you want.
                If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
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                If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
                When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
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Question 13

How do I know which test to get?

Accepted Answer

In the test options, find the test you want.
            If you’re not sure which test to get, we can lend a hand in finding the right option.
            Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
            After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop!
            If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

Absolutely! We totally understand that errors can happen. No worries, we're here to help you.
            Just reach out to us via text at 754-799-7833 or shoot us an email at
            support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update.
            Our awesome team will jump right in and make sure everything is sorted out and accurate for you.
            There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.
            Our lab requires an address to be listed to generate an order.

Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
            Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.
            This policy applies to all insurance companies, including federal health insurance programs like Medicare.
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Question 17

Can I cancel my order?

Accepted Answer

Yes.
            We get it – sometimes your needs change.
            As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.
            If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
            You can read more about our cancellation policy here.

Question 18

How can I find a lab location near me?

Accepted Answer

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached!
            You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).
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            If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

Ovarian Failure Blood Test

What is Ovarian Failure?

What causes ovarian failure?

What is the best test for ovarian failure?

When should I get tested for ovarian failure?

References

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