Orchitis Blood Test

What is Orchitis?

Orchitis is inflammation of one or both testicles that causes pain and swelling. It is primarily caused by the mumps virus, though bacterial infections from sexually transmitted organisms like Chlamydia trachomatis and Escherichia coli can also trigger it. The Measles, Mumps, Rubella (MMR) Immunity Profile is the most important test for diagnosing mumps-related orchitis.

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What causes orchitis?

Orchitis is caused primarily by the mumps virus, which accounts for the majority of viral orchitis cases in unvaccinated or inadequately vaccinated males. Bacterial causes include sexually transmitted infections like Chlamydia trachomatis and Neisseria gonorrhoeae, as well as urinary tract bacteria such as Escherichia coli that travel through the bloodstream or urinary system to the testicles. In some cases, orchitis develops as a complication of epididymitis, where infection spreads from the epididymis to the testicle itself.

What is the best test for orchitis?

The Measles, Mumps, Rubella (MMR) Immunity Profile is the most important test for orchitis because it detects antibodies against the mumps virus, the leading viral cause of testicular inflammation in adult males. This comprehensive panel measures IgG antibodies that indicate whether you have immunity from past infection or vaccination, and can reveal if elevated mumps antibodies suggest a recent infection triggering your symptoms. For additional confirmation, the Mumps Virus Antibody (IgG) test provides focused detection of mumps-specific antibodies to help determine if mumps is the underlying cause of your orchitis.

When should I get tested for orchitis?

You should get tested if you experience sudden testicular pain and swelling, especially if accompanied by fever, nausea, or recent exposure to someone with mumps. Testing is particularly important for adult males who develop testicular symptoms within two weeks of mumps-like symptoms such as swollen salivary glands, fever, or muscle aches. If you have not received the MMR vaccine or are unsure of your vaccination status and develop testicular inflammation, immediate testing can identify whether mumps is the cause and guide treatment to prevent complications like infertility or testicular atrophy.

What are the symptoms of orchitis?
Orchitis symptoms include sudden onset of testicular pain and swelling in one or both testicles, often accompanied by tenderness and a feeling of heaviness in the scrotum. You might notice fever, chills, nausea, and general body aches, particularly if the orchitis is caused by mumps virus. Other signs include blood in the semen, painful urination, discharge from the penis if a bacterial infection is present, and visible redness or warmth in the scrotal skin over the affected testicle.
Who is at risk for orchitis?
Men who have not received the MMR vaccine are at highest risk for mumps-related orchitis, particularly those between ages 15 and 35. Sexually active men who do not use barrier protection face increased risk of bacterial orchitis from STIs like chlamydia and gonorrhea. Additional risk factors include having recurrent urinary tract infections, anatomical abnormalities of the urinary tract, use of a urinary catheter, and engaging in sexual activity with multiple partners without protection.
What happens if orchitis is left untreated?
Untreated orchitis can lead to testicular atrophy where the affected testicle shrinks and loses function, potentially resulting in reduced testosterone production and fertility problems. Chronic orchitis may develop, causing persistent pain and discomfort that lasts for months or years. In severe cases, complications include abscess formation within the testicle requiring surgical drainage, permanent infertility if both testicles are affected, and rarely, loss of the testicle due to severe infection or tissue death.
Can orchitis be diagnosed with a blood test?
Orchitis is primarily diagnosed through physical examination, but blood tests play a crucial supporting role in identifying the underlying cause. The MMR Immunity Profile and Mumps Virus Antibody tests detect antibodies that indicate whether mumps virus is responsible for the testicular inflammation. Blood tests can also reveal elevated white blood cell counts suggesting infection and help rule out other conditions. While blood work does not directly visualize the inflamed testicle like ultrasound does, it provides essential information about viral or bacterial causes that guide treatment decisions.
How is orchitis treated?
Orchitis treatment depends on the underlying cause, with bacterial orchitis requiring antibiotics such as doxycycline or ceftriaxone for STI-related infections, or fluoroquinolones for urinary tract bacteria. Viral orchitis from mumps has no specific antiviral treatment and is managed with supportive care including rest, scrotal elevation with supportive underwear, ice packs to reduce swelling, and anti-inflammatory medications like ibuprofen or naproxen for pain and inflammation. Severe cases may require hospitalization for intravenous antibiotics or surgical intervention if an abscess develops.
How can I prevent orchitis?
Prevention starts with receiving the MMR vaccine, which provides strong protection against mumps-related orchitis throughout your life. Practicing safe sex by using condoms consistently reduces your risk of bacterial orchitis from sexually transmitted infections like chlamydia and gonorrhea. Regular STI screening if you are sexually active, prompt treatment of urinary tract infections, maintaining good genital hygiene, and avoiding sexual contact during active infections all help prevent orchitis. If you are exposed to someone with mumps and lack immunity, contact your healthcare provider immediately for possible preventive measures.
What can I do at home for orchitis?
At-home care for orchitis includes resting with your scrotum elevated on a rolled towel or by wearing supportive underwear to reduce swelling and discomfort. Apply cold packs wrapped in a thin cloth to the affected area for 15-20 minutes several times daily to decrease inflammation and pain. Take over-the-counter anti-inflammatory medications like ibuprofen as directed to manage pain and reduce swelling. Avoid strenuous activity, heavy lifting, and sexual activity until symptoms resolve, and stay well-hydrated to support your immune system while your body fights the infection.
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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Testosterone 375 ng/dL
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375 ng/dL

What this means

Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.

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* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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Measles, Mumps, Rubella (MMR) Immunity Profile
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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