Opioid dependence is a chronic medical condition characterized by physical and psychological reliance on opioid medications or illicit opioid drugs. It is caused by repeated exposure to opioids such as morphine, codeine, oxycodone, hydrocodone, and hydromorphone, which alter brain chemistry and create tolerance and withdrawal symptoms. The Opiate Confirmation Serum Test is the most important test for detecting opioid dependence because it measures multiple opioid drug levels in the bloodstream.
90-day money-back guarantee
Lab order in minutes
Save a trip to the doctor
Low prices since 2005
Labs within 2 miles
Opioid dependence is caused by repeated use of opioid drugs that change how your brain functions and responds to pain and pleasure. When you take opioids like morphine, oxycodone, hydrocodone, codeine, or hydromorphone regularly, your brain adapts to their presence and begins to rely on them to feel normal. Over time, your body develops tolerance, meaning you need higher doses to get the same effect, and you experience withdrawal symptoms like sweating, anxiety, muscle aches, and nausea when you stop taking them. This cycle of tolerance and withdrawal creates both physical and psychological dependence that makes it extremely difficult to quit without medical help.
The Opiate Confirmation Serum Test is the most important test for opioid dependence because it detects and measures specific opioid levels in your blood, including codeine, hydrocodone, hydromorphone, morphine, and oxycodone. This blood test provides objective evidence of recent opioid use and can show elevated drug concentrations that indicate chronic use and potential physical dependence. Unlike screening tests that simply show positive or negative results, this confirmation test measures exact drug levels, which helps healthcare providers assess the severity of dependence, monitor treatment progress, and make informed decisions about medication-assisted treatment and other therapeutic interventions.
You should get tested if you have been taking prescription opioid pain medications for more than a few weeks and notice you need higher doses to control pain, if you experience withdrawal symptoms like sweating, anxiety, or muscle aches when you miss a dose, or if you find yourself thinking about your medication constantly or taking it for reasons other than pain relief. Testing is also important if you are starting a treatment program for opioid dependence, as baseline measurements help track your progress. Additionally, if family members or friends have expressed concern about your medication use, or if you have a history of substance use issues, getting tested can provide clarity and help you access appropriate treatment before dependence becomes more severe.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.
505 reviews
Sample results
Your 24/7 Lab Guide
Quick questions:
