Non-Small Cell Lung Cancer Blood Test

What is Non-Small Cell Lung Cancer?

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for approximately 85% of all lung cancer cases. It is caused by genetic mutations in lung cells that lead to uncontrolled cell growth and tumor formation, often triggered by smoking, environmental toxins, or inherited genetic factors. The BRAF Mutation Analysis is the most important genetic test for treatment planning because it identifies specific mutations that can be targeted with precision therapies.

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What causes non-small cell lung cancer?

Non-small cell lung cancer is caused by genetic mutations in lung cells that trigger uncontrolled cell growth and tumor formation. The primary risk factor is cigarette smoking, which damages lung tissue and causes DNA mutations over time. Other causes include exposure to radon gas, asbestos, air pollution, secondhand smoke, and inherited genetic mutations. In some cases, specific genetic changes like BRAF, EGFR, or ALK mutations drive cancer development even without traditional risk factors.

What is the best test for non-small cell lung cancer?

The BRAF Mutation Analysis is the most important genetic test for non-small cell lung cancer because it identifies specific mutations in the BRAF gene that drive cancer growth and can be targeted with precision medications. While imaging studies and tissue biopsies are used for initial diagnosis, genetic testing like BRAF analysis is essential for treatment planning. This test detects whether your cancer cells have the BRAF V600E mutation, which occurs in approximately 1-3% of NSCLC cases. When this mutation is present, targeted therapies that specifically block the mutated BRAF protein can be used, often resulting in better outcomes and fewer side effects compared to traditional chemotherapy.

When should I get tested for non-small cell lung cancer?

You should get tested if you experience persistent coughing that lasts more than three weeks, coughing up blood, unexplained chest pain, shortness of breath that worsens over time, or unintentional weight loss. People with a significant smoking history (typically 20+ pack-years) between ages 50-80 should consider annual lung cancer screening with low-dose CT scans. If you have already been diagnosed with NSCLC, genetic testing like BRAF Mutation Analysis should be done immediately to guide treatment decisions and determine eligibility for targeted therapies.

What are the symptoms of non-small cell lung cancer?
Non-small cell lung cancer symptoms include a persistent cough that does not go away, coughing up blood or rust-colored phlegm, chest pain that worsens with deep breathing or coughing, hoarseness, shortness of breath, and wheezing. You might also experience unexplained weight loss, loss of appetite, fatigue, repeated respiratory infections like pneumonia or bronchitis, and bone pain if the cancer has spread. Many people have no symptoms in early stages, which is why screening is important for high-risk individuals. Advanced disease may cause swelling in the face or neck, difficulty swallowing, or neurological symptoms if it spreads to the brain.
Who is at risk for non-small cell lung cancer?
People who smoke cigarettes face the highest risk, with risk increasing with the number of cigarettes smoked daily and years of smoking. Former smokers remain at elevated risk even after quitting, though risk decreases over time. Other high-risk groups include people exposed to secondhand smoke, radon gas, asbestos, diesel exhaust, or other workplace carcinogens. Family history of lung cancer, previous radiation therapy to the chest, and air pollution exposure also increase risk. People with chronic lung diseases like COPD or pulmonary fibrosis have higher rates of lung cancer. While anyone can develop NSCLC, it most commonly affects adults over age 65.
What happens if non-small cell lung cancer is left untreated?
Untreated non-small cell lung cancer progressively grows and spreads to other parts of the body, leading to life-threatening complications. The cancer typically metastasizes to lymph nodes, bones, liver, brain, and adrenal glands, causing severe pain, neurological problems, and organ failure. You may experience increasing difficulty breathing, persistent pain, severe weight loss, and declining quality of life. Without treatment, survival time varies depending on the stage at diagnosis, but advanced NSCLC typically progresses rapidly. Early detection and treatment, including targeted therapies for specific genetic mutations, significantly improve survival rates and quality of life.
Can non-small cell lung cancer be diagnosed with a blood test?
Non-small cell lung cancer cannot be directly diagnosed with a blood test alone. Diagnosis requires imaging studies like chest X-rays or CT scans, followed by tissue biopsy to confirm cancer cells are present. However, once NSCLC is diagnosed, genetic blood tests like BRAF Mutation Analysis become crucial for treatment planning. These tests identify specific genetic mutations in cancer cells that can be targeted with precision medications. Some emerging blood tests called liquid biopsies can detect circulating tumor DNA and may help monitor treatment response or detect recurrence, but tissue biopsy remains the gold standard for initial diagnosis.
How is non-small cell lung cancer treated?
Non-small cell lung cancer treatment depends on the stage at diagnosis and specific genetic mutations present. Early-stage NSCLC is often treated with surgery to remove the tumor, sometimes followed by chemotherapy or radiation therapy. Advanced cases may receive chemotherapy, radiation, immunotherapy, or targeted therapy based on genetic testing results. If BRAF mutations are detected, targeted medications like dabrafenib and trametinib specifically block the mutated protein and can be highly effective. Immunotherapy drugs help your immune system recognize and attack cancer cells. Treatment plans are personalized based on cancer stage, genetic profile, overall health, and individual preferences, with many patients receiving combination approaches.
How can I prevent non-small cell lung cancer?
The most effective prevention strategy is never smoking or quitting if you currently smoke, as this eliminates the primary risk factor for NSCLC. Avoid exposure to secondhand smoke and test your home for radon gas, installing mitigation systems if levels are elevated. If you work with carcinogens like asbestos or diesel exhaust, always use proper protective equipment and follow safety guidelines. Maintain a healthy diet rich in fruits and vegetables, exercise regularly, and minimize exposure to air pollution when possible. For high-risk individuals with significant smoking history, annual low-dose CT screening between ages 50-80 can detect cancer at earlier, more treatable stages.
What can I do at home to support treatment for non-small cell lung cancer?
While medical treatment is essential, you can support your health at home by eating nutrient-dense foods to maintain strength during treatment, staying hydrated, and engaging in gentle physical activity as tolerated. Practice breathing exercises to improve lung function and manage shortness of breath. Get adequate rest and manage stress through meditation, relaxation techniques, or support groups. Avoid smoking and secondhand smoke completely, as continued exposure worsens outcomes. Keep your home environment clean and avoid respiratory irritants. Take all medications as prescribed and attend all follow-up appointments. Consider working with a nutritionist to address treatment side effects like nausea or appetite loss, and communicate openly with your healthcare team about symptoms or concerns.
How’s this work?
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Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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BRAF Mutation Analysis
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Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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