Non-Hodgkin's lymphoma (NHL) is a cancer that begins in the lymphatic system when white blood cells called lymphocytes grow abnormally and uncontrollably. It is caused by genetic mutations in B-cells or T-cells that lead to malignant transformation, often linked to infections like Epstein-Barr virus or Hepatitis C. The Protein, Total and Protein Electrophoresis test is the most important blood test for detecting abnormal protein patterns produced by NHL cells.
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Non-Hodgkin's lymphoma is caused by genetic mutations in lymphocytes (white blood cells) that cause them to multiply uncontrollably and live longer than normal cells. These mutations can be triggered by chronic infections like Epstein-Barr virus, Hepatitis C virus, or HIV, as well as immune system disorders and exposure to certain chemicals or radiation. Age, weakened immune function, and autoimmune diseases also increase the risk of developing these cancer-causing mutations in the lymphatic system.
The Protein, Total and Protein Electrophoresis test is the most important blood test for Non-Hodgkin's lymphoma because it detects abnormal protein patterns produced by malignant lymphoma cells. This test separates blood proteins into distinct groups and identifies unusual spikes or patterns characteristic of lymphoma activity. Additional essential tests include the Surface Light Chains test, which measures excess light chain proteins produced by NHL cells, and the Interleukin-2 Receptor Alpha Chain (IL-2Ra/CD25) test, which evaluates immune system activation levels. For patients with risk factors, the Hepatitis C Viral RNA test is critical since chronic Hepatitis C significantly increases NHL risk. While these blood tests cannot replace tissue biopsy for diagnosis, they are essential for monitoring disease activity and treatment response.
You should get tested if you notice persistent swollen lymph nodes in your neck, armpits, or groin that last more than two weeks, unexplained weight loss of more than 10 pounds, drenching night sweats, or persistent fever without infection. You should also consider testing if you have chronic fatigue that interferes with daily activities, a history of Hepatitis C or HIV infection, or if you have been treated for cancer previously. Early detection through blood work helps monitor protein abnormalities and immune markers that indicate lymphoma activity, especially if you are already diagnosed and need to track disease progression.
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What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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