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Non-alcoholic fatty liver disease (NAFLD) is a condition where excess fat accumulates in the liver of people who drink little to no alcohol. It is caused by metabolic dysfunction including insulin resistance, elevated oxidized LDL cholesterol, and increased trimethylamine N-oxide production. The Gamma Glutamyl Transpeptidase (GGT) test is the most important test for diagnosing NAFLD because it detects liver cell damage from fat accumulation.
Non-alcoholic fatty liver disease is caused by metabolic dysfunction, insulin resistance, and excess fat accumulation in liver cells. The primary drivers include elevated blood sugar levels, high triglycerides, oxidized LDL cholesterol, and obesity. Unlike alcoholic liver disease, NAFLD develops in people who drink little to no alcohol, and is strongly linked to metabolic syndrome, type 2 diabetes, and poor diet high in refined carbohydrates and saturated fats.
The Gamma Glutamyl Transpeptidase (GGT) test is the most important blood test for non-alcoholic fatty liver disease because it detects liver cell damage caused by fat accumulation. When liver cells are injured, they release GGT into the bloodstream, causing elevated levels that indicate the extent of liver damage. The OxLDL test is also essential because it measures oxidized LDL cholesterol, a key contributor to fat buildup in the liver. Additionally, the TMAO test provides valuable insight into metabolic pathways that promote liver fat accumulation and disease progression.
You should get tested if you have metabolic syndrome, type 2 diabetes, or are overweight or obese, as these significantly increase your risk. Get tested if you experience unexplained fatigue, discomfort in the upper right abdomen, or have elevated liver enzymes found during routine blood work. You should also consider testing if you have high cholesterol, high triglycerides, or a family history of liver disease, even if you have no symptoms, since NAFLD often develops silently.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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