Question 1

What is Mononucleosis?

Accepted Answer

Mononucleosis is a viral infection that causes fever, sore throat, swollen lymph nodes, and extreme fatigue. It is caused by the Epstein-Barr virus (EBV) or cytomegalovirus (CMV). The IgM antibody test is the most important test for diagnosis because it detects acute EBV infection.

Question 2

What causes mononucleosis?

Accepted Answer

Mononucleosis is caused by viral infections, primarily the Epstein-Barr virus (EBV) and less commonly cytomegalovirus (CMV). These viruses spread through saliva, which is why mono is often called the kissing disease. You can also get it from sharing drinks, eating utensils, or through coughing and sneezing. Once infected, the virus attacks your white blood cells and spreads throughout your lymphatic system, causing the characteristic swollen lymph nodes and extreme fatigue.

Question 3

What is the best test for mononucleosis?

Accepted Answer

The IgM antibody test is the most important test for mononucleosis because it detects acute Epstein-Barr virus infection, which causes most mono cases. IgM antibodies are the first immune response your body produces during an active infection, making this test highly accurate for diagnosing current mono. The Cytomegalovirus (CMV) Antibodies, IgG test is also essential when symptoms suggest mono but EBV tests are negative, as CMV is the second most common cause. Together, these tests identify which specific virus is causing your infection and confirm whether you have active mononucleosis.

Question 4

When should I get tested for mononucleosis?

Accepted Answer

You should get tested if you have a severe sore throat that does not improve with antibiotics, extreme fatigue that interferes with daily activities, swollen lymph nodes in your neck or armpits, or fever that lasts more than a few days. Testing is especially important if you are a teenager or young adult with these symptoms, as mono is most common in this age group. Get tested immediately if you develop severe abdominal pain, as this could indicate a dangerous complication involving your spleen.

Question 5

What are the symptoms of mononucleosis?

Accepted Answer

Mononucleosis symptoms include extreme fatigue that can last for weeks or months, severe sore throat often with white patches on the tonsils, fever typically ranging from 101-104°F, and swollen lymph nodes particularly in the neck and armpits. You might also experience headaches, body aches, skin rash, loss of appetite, and an enlarged spleen that causes tenderness in the upper left abdomen. Some people develop swelling around the eyes or jaundice with yellowing of the skin. Symptoms usually appear 4-6 weeks after exposure to the virus and can persist for several weeks.

Question 6

Who is at risk for mononucleosis?

Accepted Answer

Teenagers and young adults between ages 15-25 are at highest risk for mononucleosis, though anyone can get infected at any age. College students living in dorms and high school students are particularly vulnerable due to close contact and sharing of drinks or utensils. People with weakened immune systems from conditions like HIV or from taking immunosuppressive medications face increased risk. Athletes who share water bottles and those who engage in intimate contact like kissing are more likely to contract the virus. Most adults have already been exposed to EBV by age 35, which provides some immunity.

Question 7

What happens if mononucleosis is left untreated?

Accepted Answer

Untreated mononucleosis can lead to a ruptured spleen, which is a life-threatening emergency that causes severe abdominal pain and internal bleeding. The extreme fatigue can persist for months, significantly impacting your ability to work, study, or participate in normal activities. Some people develop severe throat swelling that blocks airways and requires immediate medical attention. Liver inflammation and jaundice can occur, affecting liver function. In rare cases, mononucleosis can cause neurological complications like meningitis or Guillain-Barré syndrome. Getting proper diagnosis and following treatment guidelines helps prevent these serious complications.

Question 8

Can mononucleosis be diagnosed with a blood test?

Accepted Answer

Mononucleosis can be definitively diagnosed with blood tests that detect specific antibodies to the Epstein-Barr virus or cytomegalovirus. The IgM antibody test identifies acute EBV infection, while the monospot test detects heterophile antibodies that appear during mono. A complete blood count (CBC) shows characteristic changes like elevated lymphocytes and atypical white blood cells. Your doctor might also order liver function tests since mono can affect the liver. Blood tests are far more accurate than diagnosis based on symptoms alone, as many conditions mimic mononucleosis.

Question 9

How is mononucleosis treated?

Accepted Answer

Mononucleosis treatment focuses on rest and symptom management since antibiotics do not work against viral infections. You need plenty of sleep and should avoid strenuous activities and contact sports for at least 3-4 weeks to prevent spleen rupture. Over-the-counter pain relievers like acetaminophen or ibuprofen help reduce fever and throat pain. Gargling with warm salt water and drinking plenty of fluids soothes the sore throat. Corticosteroids may be prescribed in severe cases with extreme throat swelling or complications. Most people recover fully within 2-4 weeks, though fatigue can linger for months.

Question 10

How can I prevent mononucleosis?

Accepted Answer

Prevent mononucleosis by avoiding sharing drinks, food, utensils, toothbrushes, or lip products with others, especially if they are sick. Do not kiss anyone who has active mono or has been recently diagnosed. Wash your hands frequently with soap and water, particularly before eating and after being in public places. Maintain a strong immune system through adequate sleep, balanced nutrition, regular exercise, and stress management. If you live with someone who has mono, disinfect shared surfaces and avoid close contact until they recover. There is no vaccine for EBV or CMV, so these preventive measures are essential.

Question 11

What natural remedies help with mononucleosis?

Accepted Answer

Natural remedies that support recovery from mononucleosis include drinking warm herbal teas with honey and lemon to soothe throat pain and staying well-hydrated with water, broth, and electrolyte drinks. Eating soft, nutritious foods like yogurt, smoothies, and soup provides energy without irritating your throat. Taking vitamin C and zinc supplements may support immune function, though you should consult your doctor first. Using a humidifier adds moisture to the air and eases breathing. Gentle activities like short walks can help maintain energy once the acute phase passes, but listen to your body and rest when needed. These remedies complement medical treatment but do not replace proper diagnosis and monitoring.

Question 12

How’s this work?

Accepted Answer

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Question 13

How do I know which test to get?

Accepted Answer

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Question 14

When will my lab results be available?

Accepted Answer

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Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

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Question 16

Do you accept health insurance?

Accepted Answer

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Question 17

Can I cancel my order?

Accepted Answer

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Question 18

How can I find a lab location near me?

Accepted Answer

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Mononucleosis Blood Test

What is Mononucleosis?

What causes mononucleosis?

What is the best test for mononucleosis?

When should I get tested for mononucleosis?

References

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