Miscarriage Blood Test & Fetal Death Blood Work

What is Miscarriage or Fetal Death?

Miscarriage or fetal death is the loss of pregnancy before the fetus can survive outside the womb, typically before 20 weeks of gestation. Recurrent miscarriages are often caused by antiphospholipid syndrome, an autoimmune condition where cardiolipin antibodies attack blood vessels and create clots in placental circulation. The Cardiolipin Antibodies test is the most important test for diagnosis because it identifies the specific IgA, IgG, and IgM antibodies responsible for blood clotting disorders that lead to pregnancy loss.

RECOMMENDED TEST Cardiolipin Antibodies (IgA, IgG, IgM)
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What causes recurrent miscarriages?

Recurrent miscarriages are most commonly caused by antiphospholipid syndrome, an autoimmune disorder where the body produces cardiolipin antibodies that attack phospholipids in blood vessel walls. These antibodies create abnormal blood clots in the tiny vessels of the placenta, cutting off oxygen and nutrients to the developing baby. Other causes include chromosomal abnormalities, uterine structural problems, hormonal imbalances like thyroid disorders or uncontrolled diabetes, and infections, but blood clotting disorders account for a significant portion of repeat pregnancy losses.

What is the best test for recurrent miscarriages?

The Cardiolipin Antibodies test is the most important test for recurrent miscarriages because it detects the specific IgA, IgG, and IgM antibodies that cause blood clots in placental blood vessels. This test identifies antiphospholipid syndrome, a treatable autoimmune condition responsible for many second and third-trimester pregnancy losses. Elevated IgG and IgM cardiolipin antibodies are particularly significant because they directly indicate an increased clotting risk that can be managed with blood thinners and aspirin therapy during pregnancy. Early detection through this blood test allows your healthcare provider to develop a prevention plan that significantly improves the chances of carrying a pregnancy to term.

When should I get tested for miscarriage causes?

You should get tested if you have experienced two or more miscarriages, especially if any occurred after the first trimester when chromosomal issues are less likely. Testing is particularly important if you have a personal or family history of blood clots, autoimmune diseases like lupus, or unexplained fetal death in the second or third trimester. Many doctors also recommend testing after just one late pregnancy loss or if you are planning another pregnancy after multiple early losses, because identifying and treating clotting disorders before conception can prevent future heartbreak.

What are the symptoms of antiphospholipid syndrome?
Antiphospholipid syndrome often has no obvious symptoms until pregnancy complications occur, making it a silent threat to carrying a baby to term. Beyond recurrent miscarriages, you might experience blood clots in your legs causing pain and swelling, unexplained migraines, a lacy purple rash on your skin called livedo reticularis, or previous instances of deep vein thrombosis or pulmonary embolism. Some women only discover they have this condition after multiple pregnancy losses, which is why testing cardiolipin antibodies is so crucial for anyone with a history of miscarriage.
Who is at risk for pregnancy loss from clotting disorders?
Women with autoimmune diseases like lupus or rheumatoid arthritis are at higher risk for antiphospholipid syndrome and pregnancy loss. Those with a personal or family history of blood clots, stroke at a young age, or unexplained pregnancy complications are also at increased risk. Additionally, women who have already experienced one or more miscarriages, particularly in the second trimester, have a higher likelihood of having an underlying clotting disorder. Age over 35, obesity, and certain genetic clotting mutations also increase the risk of pregnancy loss related to blood clotting problems.
What happens if antiphospholipid syndrome is left untreated during pregnancy?
Untreated antiphospholipid syndrome dramatically increases the risk of recurrent miscarriages, with some studies showing pregnancy loss rates as high as 90 percent without treatment. Beyond miscarriage, untreated clotting disorders can cause severe pregnancy complications including preeclampsia with dangerously high blood pressure, placental abruption where the placenta separates from the uterus, premature birth, and intrauterine growth restriction where the baby does not grow properly. The mother also faces increased risks of blood clots in her legs, lungs, or brain, which can be life-threatening even after pregnancy ends.
Can miscarriage risk be diagnosed with a blood test?
Yes, the Cardiolipin Antibodies blood test can diagnose antiphospholipid syndrome, one of the most treatable causes of recurrent miscarriage. This test measures three types of antibodies in your blood that attack phospholipids and cause abnormal clotting in placental vessels. While blood tests cannot predict or diagnose every cause of miscarriage, they are essential for identifying autoimmune clotting disorders, thyroid problems, uncontrolled diabetes, and certain infections that contribute to pregnancy loss. Identifying these conditions through blood work before or early in pregnancy allows for treatments that significantly improve the chances of a successful pregnancy.
How is antiphospholipid syndrome treated during pregnancy?
Antiphospholipid syndrome is treated with low-dose aspirin and heparin injections throughout pregnancy to prevent abnormal blood clots from forming in the placenta. This combination therapy has been shown to increase live birth rates from around 10 percent to 70-80 percent in women with this condition. Your doctor will monitor you closely with frequent ultrasounds and blood pressure checks to watch for complications like preeclampsia or poor fetal growth. Some women may also need corticosteroids if they have severe autoimmune symptoms, and treatment typically continues for several weeks after delivery to prevent postpartum blood clots.
How can I prevent future miscarriages?
Prevention starts with identifying any underlying causes through blood testing for clotting disorders, thyroid problems, and autoimmune conditions before trying to conceive again. If tests reveal antiphospholipid syndrome or other clotting issues, starting aspirin and blood thinners before pregnancy significantly reduces miscarriage risk. Maintaining a healthy weight, controlling diabetes and blood pressure, avoiding smoking and alcohol, taking prenatal vitamins with folic acid, and managing stress all support a healthy pregnancy. Work closely with a maternal-fetal medicine specialist or reproductive endocrinologist who can create a personalized prevention plan based on your specific test results and medical history.
What can I do at home to support pregnancy after miscarriage?
After experiencing miscarriage, give your body at least one normal menstrual cycle to heal before trying again, though some doctors recommend waiting longer for emotional healing. Take a high-quality prenatal vitamin with at least 400-800 mcg of folic acid daily, eat a balanced diet rich in fruits, vegetables, and lean proteins, and stay hydrated. Manage stress through gentle exercise like walking or prenatal yoga, adequate sleep, and counseling or support groups if needed. Avoid alcohol, smoking, and excessive caffeine, and discuss any medications or supplements with your doctor. Most importantly, get tested for underlying causes so any treatable conditions can be managed before your next pregnancy.
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Cardiolipin Antibodies (IgA, IgG, IgM)
Google reviews 505 reviews
$398 $310
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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