Migraine Blood Test & Brain Chemistry Panel

What is Migraine?

Migraine is a neurological condition characterized by recurring, severe headaches often accompanied by nausea, visual disturbances, and sensitivity to light and sound. It is caused by fluctuations in brain chemistry, particularly serotonin levels, which trigger changes in blood vessel activity and nerve signaling. The Serotonin, Serum test is the most important test for monitoring migraine patterns because it measures the neurotransmitter fluctuations that occur during migraine episodes.

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What causes migraines?

Migraines are caused by fluctuations in brain chemistry, particularly changes in serotonin levels, combined with abnormal brain activity that affects blood vessels and nerve signals. During a migraine attack, serotonin levels spike initially, causing blood vessels in the brain to constrict, then drop dramatically, leading to blood vessel dilation and the throbbing pain characteristic of migraines. Additional triggers include hormonal changes (especially fluctuations in estrogen), certain foods and drinks, stress, sleep disruptions, sensory stimuli like bright lights or strong smells, and environmental factors, though the underlying mechanism always involves neurotransmitter imbalances.

What is the best test for migraines?

The Serotonin, Serum test is the most important test for understanding migraine patterns because it measures the neurotransmitter fluctuations that occur during migraine episodes. This blood test tracks serotonin levels, which spike at the onset of a migraine and then drop significantly during the attack phase, helping identify your individual biochemical patterns. While migraines are primarily diagnosed through medical history and symptom evaluation, monitoring serotonin levels provides valuable insights into brain chemistry changes that trigger and prolong migraine episodes, allowing healthcare providers to develop more targeted treatment strategies based on your specific neurochemical profile.

When should I get tested for migraines?

You should get tested if you experience recurring severe headaches that interfere with daily activities, especially if accompanied by nausea, visual disturbances like auras or blind spots, or extreme sensitivity to light and sound. Testing is particularly valuable if your migraines are becoming more frequent or severe, if you want to identify patterns in your migraine triggers, or if current treatments are not providing adequate relief. Consider testing before starting or adjusting migraine medications to establish a baseline of your brain chemistry, or if you experience migraines that last more than 24 hours, as monitoring serotonin fluctuations can help your healthcare provider optimize your treatment plan.

What are the symptoms of migraines?
Migraine symptoms include intense, throbbing pain typically on one side of the head, though it can affect both sides. Many people experience warning signs called auras, which include visual disturbances like flashing lights, zigzag patterns, or temporary blind spots appearing 10 to 30 minutes before the headache begins. During the migraine attack, you might experience severe nausea and vomiting, extreme sensitivity to light (photophobia) and sound (phonophobia), dizziness or vertigo, and difficulty concentrating. Some people also experience tingling or numbness in the face or extremities, and attacks can last anywhere from 4 hours to 3 days if untreated.
Who is at risk for migraines?
Women are three times more likely to experience migraines than men, largely due to hormonal fluctuations related to menstruation, pregnancy, and menopause. Migraines often run in families, with about 80% of migraine sufferers having a family history of the condition. People between ages 15 and 55 are most susceptible, though migraines can begin at any age. Additional risk factors include high stress levels, anxiety or depression, irregular sleep patterns, hormonal medications like birth control pills, and certain lifestyle factors such as smoking, excessive caffeine consumption, or skipping meals. People with other neurological conditions or those who experienced motion sickness as children also have increased migraine risk.
What happens if migraines are left untreated?
Untreated or poorly managed migraines can lead to chronic daily headaches, where headaches occur 15 or more days per month, significantly impacting quality of life. Frequent migraines increase the risk of medication overuse headaches, creating a cycle of worsening pain and increased medication dependence. Long-term complications include an increased risk of stroke, particularly in women under 45 who experience migraines with aura, as well as mental health issues like depression and anxiety from dealing with chronic pain. Untreated migraines can also lead to decreased productivity, missed work or school, strained relationships, and reduced ability to participate in daily activities, while severe attacks may result in persistent neurological symptoms or status migrainosus, a debilitating migraine lasting more than 72 hours requiring emergency treatment.
Can migraines be diagnosed with a blood test?
Migraines cannot be definitively diagnosed with a blood test alone, as diagnosis is primarily based on medical history, symptom patterns, and physical examination. However, blood tests like the Serotonin, Serum test play a valuable role in monitoring the biochemical changes that occur during migraine episodes and can help identify patterns in brain chemistry fluctuations. Blood testing is useful for ruling out other conditions that might cause similar symptoms, such as thyroid disorders, infections, or nutritional deficiencies. Measuring serotonin levels during different phases of your migraine cycle provides insights that help healthcare providers understand your individual migraine triggers and optimize treatment strategies, even though the diagnosis itself relies on clinical criteria rather than laboratory values.
How are migraines treated?
Migraine treatment involves both acute medications to stop attacks in progress and preventive medications to reduce frequency and severity. Acute treatments include over-the-counter pain relievers like ibuprofen or aspirin for mild migraines, triptans (such as sumatriptan) that target serotonin receptors to reverse brain chemistry changes, and anti-nausea medications. For chronic migraines, preventive medications include beta-blockers, anticonvulsants, antidepressants, or newer CGRP inhibitors that block pain pathways. Non-medication approaches include identifying and avoiding triggers, maintaining regular sleep schedules, managing stress through relaxation techniques or biofeedback, staying hydrated, and applying cold or hot compresses during attacks. Many people benefit from a combination approach tailored to their specific migraine patterns and serotonin fluctuation profiles.
How can I prevent migraines?
Preventing migraines involves identifying and avoiding your personal triggers while maintaining consistent daily routines. Keep a migraine diary to track potential triggers like specific foods (aged cheeses, processed meats, alcohol, caffeine), hormonal changes, stress, sleep disruptions, or weather changes. Maintain regular sleep schedules by going to bed and waking at the same time daily, even on weekends. Stay well-hydrated and eat regular meals to avoid blood sugar fluctuations. Practice stress management through regular exercise, yoga, meditation, or deep breathing exercises. Limit caffeine intake to consistent daily amounts and avoid sudden changes. Consider supplementing with magnesium, riboflavin (vitamin B2), or coenzyme Q10, which some studies suggest may reduce migraine frequency, though always consult your healthcare provider before starting supplements.
What natural remedies help with migraines?
Natural remedies that may help manage migraines include applying cold compresses or ice packs to the forehead or back of the neck during an attack to constrict blood vessels and reduce inflammation. Magnesium supplementation (400-500 mg daily) may help prevent migraines, as many migraine sufferers have low magnesium levels. Riboflavin (vitamin B2) at 400 mg daily and coenzyme Q10 supplements have shown promise in reducing migraine frequency. Herbal remedies like feverfew and butterbur extract may provide preventive benefits, though quality and dosing vary. Aromatherapy with peppermint or lavender essential oils applied to temples may ease pain, while ginger tea can help reduce nausea. Acupuncture and biofeedback have demonstrated effectiveness for some people in clinical studies. Resting in a dark, quiet room and practicing relaxation techniques during attacks can also provide relief.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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Serotonin, Serum
Google reviews 505 reviews
$103 $80
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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