Meningitis or Encephalitis Blood Test

What is Meningitis or Encephalitis?

Meningitis and encephalitis are serious inflammatory conditions affecting the brain, spinal cord, or their protective membranes. These conditions can be caused by viral infections such as Herpes Simplex Virus 2 (HSV-2), enteroviruses, and West Nile virus, as well as bacterial pathogens like Streptococcus pneumoniae and Neisseria meningitidis. The Herpes Simplex Virus 2 IgG Type-Specific Antibody test is the most important blood test for identifying HSV-2 as a potential viral cause of these conditions.

RECOMMENDED TEST Herpes Simplex Virus 2 (IgG), Type-Specific Antibody
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Fast & easy, results by email & SMS
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No need to visit a doctor
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What causes meningitis or encephalitis?

Meningitis and encephalitis are caused by infections that inflame the brain, spinal cord, or their protective membranes. Viral causes include Herpes Simplex Virus 2 (HSV-2), enteroviruses, West Nile virus, and mumps virus, while bacterial causes include Streptococcus pneumoniae, Neisseria meningitidis, and Listeria monocytogenes. Less commonly, fungal infections like Cryptococcus or parasites can also trigger these conditions, particularly in people with weakened immune systems.

What is the best test for meningitis or encephalitis?

The Herpes Simplex Virus 2 IgG Type-Specific Antibody test is the most important blood test for identifying HSV-2 as a potential viral cause of meningitis or encephalitis. This test detects antibodies against HSV-2, which can infect and inflame brain tissue or the membranes covering the brain and spinal cord. While the primary diagnosis relies on cerebrospinal fluid analysis through a lumbar puncture and brain imaging studies, blood antibody testing provides crucial supporting information about viral exposure. High levels of HSV-2 IgG antibodies help healthcare providers understand whether this virus might be responsible for the neurological inflammation and guide appropriate antiviral treatment decisions.

When should I get tested for meningitis or encephalitis?

You should get tested immediately if you experience severe headache with stiff neck, high fever with confusion or altered mental status, sudden sensitivity to light with severe nausea or vomiting, or seizures combined with any neurological symptoms. These are medical emergencies requiring urgent evaluation. Blood testing for viral causes like HSV-2 should be performed alongside other diagnostic procedures when your healthcare provider suspects a viral infection is causing your symptoms, especially if you have a history of herpes infections or risk factors for viral meningitis.

What are the symptoms of meningitis or encephalitis?
Meningitis and encephalitis cause severe headache, high fever, and stiff neck that makes it painful to touch your chin to your chest. You might experience confusion, difficulty concentrating, personality changes, or problems with memory and speech. Other symptoms include extreme sensitivity to light, severe nausea and vomiting, drowsiness or difficulty waking up, seizures, and in infants, a bulging soft spot on the head with irritability and poor feeding. Encephalitis specifically may cause behavioral changes, hallucinations, and muscle weakness or paralysis.
Who is at risk for meningitis or encephalitis?
People with weakened immune systems from HIV, cancer treatment, or immunosuppressive medications face higher risk for meningitis and encephalitis. Infants, young children, and adults over 60 have increased vulnerability due to developing or declining immune function. Those who skip vaccinations for measles, mumps, and meningococcal disease, live in close quarters like college dormitories or military barracks, or have had recent head trauma or neurosurgery are at elevated risk. Additionally, people with active herpes infections, particularly HSV-2, may rarely develop viral meningitis or encephalitis.
What happens if meningitis or encephalitis is left untreated?
Untreated meningitis and encephalitis can cause permanent brain damage, including memory loss, learning disabilities, hearing loss, and speech problems. You may develop seizure disorders that require lifelong medication, experience paralysis or muscle weakness, and suffer cognitive impairments affecting concentration and decision-making. Bacterial meningitis can lead to septic shock, organ failure, and death within hours to days without treatment. Even viral forms can cause lasting neurological damage, vision problems, balance and coordination issues, and in severe cases, coma or death, making immediate medical intervention essential for the best possible outcome.
Can meningitis or encephalitis be diagnosed with a blood test?
Blood tests alone cannot diagnose meningitis or encephalitis, but they play an important supporting role in identifying potential viral causes. The primary diagnosis requires cerebrospinal fluid analysis obtained through a lumbar puncture, which examines the fluid surrounding your brain and spinal cord for infection markers. Blood tests like the HSV-2 antibody test help determine if specific viruses might be responsible for the inflammation, guiding treatment decisions. Healthcare providers combine blood test results with spinal fluid analysis, brain imaging studies, and clinical symptoms to make a complete diagnosis and develop an appropriate treatment plan.
How is meningitis or encephalitis treated?
Bacterial meningitis requires immediate intravenous antibiotics, often started before test results confirm the diagnosis, along with corticosteroids to reduce brain inflammation. Viral meningitis and encephalitis caused by HSV-2 are treated with antiviral medications like acyclovir administered intravenously for maximum effectiveness. Treatment includes supportive care with intravenous fluids, fever-reducing medications, and seizure control drugs if needed. Severe cases may require intensive care monitoring, breathing support, and medications to reduce brain swelling. Early treatment significantly improves outcomes, which is why immediate medical attention is critical when symptoms appear.
How can I prevent meningitis or encephalitis?
Vaccination provides the best protection against meningitis, including vaccines for meningococcal disease, pneumococcal bacteria, measles, mumps, rubella, and varicella. Practice good hygiene by washing hands frequently, especially before eating and after using the bathroom, and avoid sharing drinks, utensils, or personal items with others. If you have active herpes infections, including HSV-2, work with your healthcare provider to manage outbreaks with antiviral medications, reducing the rare risk of viral spread to the nervous system. Avoid mosquito bites in areas with West Nile virus by using insect repellent and wearing protective clothing during peak mosquito hours.
What can I do at home to support recovery from meningitis or encephalitis?
After hospitalization and medical treatment, get plenty of rest in a quiet, darkened room to help reduce headache and light sensitivity during recovery. Stay well-hydrated by drinking water, clear broths, and electrolyte solutions to support your immune system and overall healing. Take prescribed medications exactly as directed, including completing the full course of antibiotics or antivirals even if you feel better. Avoid alcohol and limit screen time to reduce strain on your recovering brain. Follow up with all scheduled medical appointments to monitor for complications, and gradually return to normal activities only when your healthcare provider clears you, as rushing recovery can lead to setbacks.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Herpes Simplex Virus 2 (IgG), Type-Specific Antibody
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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