Melanoma is a serious form of skin cancer that develops when pigment-producing cells called melanocytes become malignant. It is caused by uncontrolled cell growth driven by genetic mutations, most commonly in the BRAF gene which occurs in approximately 50% of melanoma cases. The BRAF Mutation Analysis is the most important genetic test for melanoma because it identifies mutations that determine eligibility for targeted therapies.
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Melanoma is caused by genetic mutations in skin cells called melanocytes that produce pigment. The most common mutation occurs in the BRAF gene, found in about 50% of melanomas, specifically the V600E mutation. These mutations cause cells to grow and divide uncontrollably, leading to tumor development. UV radiation from sun exposure or tanning beds is the primary environmental trigger that damages DNA and causes these mutations, though some melanomas occur in areas not exposed to sun.
The BRAF Mutation Analysis is the most important genetic test for melanoma because it identifies mutations that determine the best treatment approach. This test detects BRAF gene mutations, particularly the V600E mutation present in approximately 50% of melanomas. Identifying these mutations is essential because targeted therapies like BRAF inhibitors are specifically designed to block the effects of mutated BRAF proteins, significantly improving treatment outcomes. While melanoma itself is diagnosed through skin biopsy and histological examination, genetic testing of the tumor tissue is crucial for personalizing treatment decisions and selecting the most effective targeted therapies for each patient.
You should get tested for BRAF mutations after melanoma has been diagnosed through biopsy and confirmed by a pathologist. Genetic testing is typically ordered by your oncologist when planning treatment for advanced melanoma, metastatic melanoma, or melanoma that cannot be completely removed surgically. Testing is especially important if you are a candidate for targeted therapy or immunotherapy, as knowing your mutation status helps your healthcare team select the most effective treatment options. Earlier testing allows for faster treatment decisions and access to personalized therapies.
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What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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