Lyme Disease Blood Test

What is Lyme Disease?

Lyme disease is a bacterial infection transmitted through the bite of infected black-legged ticks. It is caused by the bacterium Borrelia burgdorferi, which enters the bloodstream and spreads throughout the body. The Lyme Disease Antibody with Reflex to Antibodies IGG & IGM Blot is the most important test for diagnosis because it detects specific antibodies your immune system produces in response to the infection.

RECOMMENDED TEST Lyme Disease Antibody with Reflex to Antibodies IGG & IGM Blot
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Fast & easy, results by email & SMS
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Results explained
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What causes Lyme disease?

Lyme disease is caused by the bacterium Borrelia burgdorferi, which is transmitted to humans through the bite of infected black-legged ticks (also called deer ticks). These tiny ticks pick up the bacteria when they feed on infected mice, deer, or other animals, and then transfer it to people during their next blood meal. The tick typically needs to be attached to your skin for 36 to 48 hours before the bacteria can be transmitted, which is why prompt tick removal is so important for prevention.

What is the best test for Lyme disease?

The Lyme Disease Antibody with Reflex to Antibodies IGG & IGM Blot is the most important test for Lyme disease because it uses a two-tier approach to accurately detect infection. This test first screens for antibodies against Borrelia burgdorferi, then automatically performs more specific immunoblot testing if the initial screen is positive. The immunoblot identifies both IgM antibodies (which appear 2-4 weeks after a tick bite and indicate recent infection) and IgG antibodies (which develop later and can persist for years, indicating past infection or late-stage disease). For additional confirmation, the Lyme Disease Antibodies (IgG, IgM) Immunoblot can be used as a standalone test to analyze specific protein bands characteristic of Lyme disease, providing detailed information about your immune response to the bacteria.

When should I get tested for Lyme disease?

You should get tested if you develop symptoms after spending time in wooded or grassy areas where ticks are common, especially if you found a tick attached to your skin. Look for signs like a spreading bull's-eye rash (erythema migrans), unexplained fever, severe fatigue, headaches, muscle and joint aches, or swollen lymph nodes within days to weeks after potential tick exposure. Even if you do not remember being bitten, get tested if you develop these symptoms and live in or have visited areas where Lyme disease is prevalent, such as the Northeast, Mid-Atlantic, or upper Midwest United States. Early detection and treatment are crucial to prevent the infection from progressing to more serious complications affecting your joints, heart, and nervous system.

What are the symptoms of Lyme disease?
Early symptoms of Lyme disease typically appear 3 to 30 days after a tick bite and include fever, chills, headache, fatigue, muscle and joint aches, and swollen lymph nodes. The most distinctive early sign is erythema migrans, a red expanding rash that often looks like a bull's-eye and appears at the site of the tick bite in about 70-80% of infected people. If left untreated, the infection can spread and cause severe joint pain and swelling (especially in the knees), facial paralysis (Bell's palsy), irregular heartbeat, dizziness, nerve pain, and memory problems. Some people develop arthritis, chronic fatigue, or neurological issues that can persist for months or years after the initial infection.
Who is at risk for Lyme disease?
People who spend time outdoors in wooded, bushy, or grassy areas where ticks thrive are at highest risk for Lyme disease. This includes hikers, campers, hunters, outdoor workers like landscapers and foresters, and children who play in areas with tall grass or leaf litter. Geographic location matters significantly, with the highest risk in the Northeast, Mid-Atlantic, and upper Midwest regions of the United States where black-legged ticks are most common. The risk is greatest during late spring through early fall when ticks are most active and people spend more time outside. Having pets that go outdoors can also increase your risk, as dogs and cats can bring ticks into your home on their fur.
What happens if Lyme disease is left untreated?
Untreated Lyme disease can spread from the initial bite site to other parts of your body, causing serious complications that affect multiple organ systems. Within weeks to months, the bacteria can attack your joints, leading to severe arthritis with painful swelling, particularly in the knees. The infection can also affect your heart, causing Lyme carditis with irregular heartbeat, chest pain, and shortness of breath. Neurological complications are common and may include meningitis, facial paralysis, nerve pain, numbness in the hands or feet, and problems with memory and concentration. Some people develop Post-Treatment Lyme Disease Syndrome (PTLDS), experiencing fatigue, pain, and cognitive difficulties that can last for months or years even after antibiotic treatment. Early diagnosis and treatment are essential to prevent these long-term complications.
Can Lyme disease be diagnosed with a blood test?
Yes, Lyme disease can be diagnosed with blood tests that detect antibodies your immune system produces in response to Borrelia burgdorferi infection. The standard approach uses a two-tier testing system starting with a screening test, followed by a more specific immunoblot test if the initial result is positive or equivocal. However, timing is crucial because antibodies may not be detectable in the first few weeks after infection, which means testing too early can produce false-negative results. If you have the characteristic bull's-eye rash and recent tick exposure, your doctor may start treatment immediately without waiting for test results. Blood tests are most reliable when performed at least 4 weeks after suspected infection, and results must be interpreted alongside your symptoms and clinical history for accurate diagnosis.
How is Lyme disease treated?
Lyme disease is treated with antibiotics, and early treatment leads to the best outcomes with full recovery in most cases. For early-stage Lyme disease, doctors typically prescribe oral antibiotics like doxycycline, amoxicillin, or cefuroxime for 10 to 21 days, depending on the specific symptoms and stage of infection. If the disease has spread to the nervous system or heart, intravenous antibiotics may be necessary for 14 to 28 days. Most people feel significantly better within a few weeks of starting antibiotics, though some symptoms like fatigue and joint pain may take longer to resolve. It is important to complete the full course of antibiotics even if you start feeling better, and follow up with your healthcare provider to ensure the infection has been successfully treated.
How can I prevent Lyme disease?
The best way to prevent Lyme disease is to avoid tick bites by taking protective measures when spending time outdoors in areas where ticks are common. Wear long sleeves, long pants tucked into socks, and light-colored clothing so you can easily spot ticks. Use EPA-registered insect repellents containing DEET, picaridin, or permethrin on skin and clothing, and treat outdoor gear with permethrin spray. Walk in the center of trails and avoid brushy, wooded areas with tall grass and leaf litter where ticks live. After outdoor activities, perform thorough tick checks on yourself, children, and pets, paying special attention to hidden areas like the scalp, behind ears, armpits, groin, and behind knees. Shower within two hours of coming indoors and tumble-dry clothes on high heat for 10 minutes to kill any ticks. Remove attached ticks promptly using fine-tipped tweezers, grasping close to the skin and pulling upward with steady pressure.
What can I do at home to support recovery from Lyme disease?
While antibiotics are essential for treating Lyme disease, you can support your recovery at home by getting plenty of rest to help your body fight the infection and manage fatigue. Stay well-hydrated and eat a nutritious, anti-inflammatory diet rich in fruits, vegetables, lean proteins, and omega-3 fatty acids to support your immune system. Gentle exercise like walking or stretching can help reduce joint stiffness and improve overall well-being, but avoid overexertion and listen to your body's signals. Use over-the-counter pain relievers like ibuprofen or acetaminophen to manage headaches, fever, and muscle aches as recommended by your healthcare provider. Keep the tick bite area clean and monitor it for any changes. If you experience persistent or worsening symptoms despite treatment, contact your doctor promptly, as you may need additional evaluation or a longer course of antibiotics.
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Long story short:
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  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
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  8. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

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Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
Can I cancel my order?
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We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Lyme Disease Antibody with Reflex to Antibodies IGG & IGM Blot
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No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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