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Leukopenia is a condition characterized by an abnormally low white blood cell count in the blood, typically below 4,000 cells per microliter. It is caused by bone marrow disorders, autoimmune diseases, severe infections, chemotherapy drugs, or nutritional deficiencies that suppress white blood cell production. The Complete Blood Count with Differential is the most important test for diagnosis because it measures total white blood cell levels and identifies which specific types are affected.
Leukopenia is caused by conditions that suppress or damage white blood cell production in the bone marrow. Common causes include chemotherapy and radiation therapy for cancer, autoimmune disorders like lupus and rheumatoid arthritis, viral infections such as HIV and hepatitis, certain medications including antibiotics and anti-seizure drugs, bone marrow disorders like aplastic anemia and myelodysplastic syndromes, and nutritional deficiencies in vitamin B12, folate, or copper. Severe bacterial infections and sepsis can also temporarily deplete white blood cells as the immune system fights the infection.
The Complete Blood Count with Differential is the most important test for leukopenia because it measures your total white blood cell count and breaks down the specific types of white blood cells affected, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils. This detailed breakdown helps doctors identify whether you have a general decrease in all white blood cells or if specific types are low, which points to different underlying causes. Normal white blood cell counts range from 4,000 to 11,000 cells per microliter, and the test shows exactly where your levels fall. The differential is crucial because neutropenia (low neutrophils) carries different risks than lymphopenia (low lymphocytes), allowing your healthcare provider to assess infection risk and determine the appropriate treatment approach.
You should get tested if you experience frequent infections that take longer to heal than usual, persistent fever without an obvious cause, unexplained fatigue or weakness, mouth sores or ulcers that keep returning, or unusual bruising and bleeding. Testing is also important if you are undergoing chemotherapy or radiation treatment, taking medications known to affect white blood cell counts like certain antibiotics or immunosuppressants, or have been diagnosed with an autoimmune disorder. If you notice you are getting sick more often than normal or infections seem more severe, a Complete Blood Count can identify if low white blood cells are compromising your immune system.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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