Latent tuberculosis infection (LTBI) is a condition where Mycobacterium tuberculosis bacteria remain dormant in the body without causing active disease or symptoms. The bacteria are transmitted through airborne droplets from people with active tuberculosis and can remain inactive for years or decades. The QuantiFERON-TB Gold Plus test is the most important test for diagnosing latent tuberculosis because it detects the immune system's response to TB bacteria even when no symptoms are present.
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Latent tuberculosis infection is caused by Mycobacterium tuberculosis bacteria that enter the body through inhalation of airborne droplets when an infected person with active TB coughs, sneezes, or speaks. Once inhaled, the bacteria settle in the lungs where the immune system typically contains them by forming protective barriers, preventing them from multiplying and causing active disease. While the bacteria remain alive in the body, they stay dormant and do not cause symptoms or spread to others, but they can potentially reactivate later if the immune system weakens.
The QuantiFERON-TB Gold Plus test is the most important blood test for latent tuberculosis infection because it measures specific immune cell responses to TB antigens, accurately detecting whether Mycobacterium tuberculosis bacteria are present in your body. This advanced interferon-gamma release assay (IGRA) is superior to traditional skin tests because it requires only one visit, eliminates false positives from BCG vaccination, and provides objective laboratory results within 24 hours. The test identifies both recent and remote TB infections, helping doctors determine who needs preventive treatment to stop dormant bacteria from becoming active tuberculosis disease.
You should get tested if you have been in close contact with someone diagnosed with active tuberculosis, recently immigrated from or traveled to countries with high TB rates, work or live in high-risk settings like healthcare facilities or homeless shelters, or have a weakened immune system due to HIV, diabetes, or immunosuppressive medications. Testing is especially important before starting medications that suppress the immune system, such as biologics for autoimmune conditions, since these can activate dormant TB bacteria and cause serious illness.
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What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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