Latent Syphilis Blood Test

What is Latent Syphilis?

Latent syphilis is a stage of syphilis infection where the bacteria Treponema pallidum remains in the body but causes no visible symptoms. It is caused by untreated primary or secondary syphilis that progresses to a silent phase that can last for years. The Syphilis Antibody Cascading Reflex test is the most important test for diagnosis because it detects antibodies even when no symptoms are present.

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What causes latent syphilis?

Latent syphilis is caused by the bacteria Treponema pallidum that remains dormant in your body after the initial infection phases. When primary or secondary syphilis goes untreated or is inadequately treated, the bacteria enter a hidden phase where they continue to live in your body without causing noticeable symptoms. During this silent stage, the infection can still be detected through blood tests and may be transmitted to sexual partners or from mother to baby during pregnancy, even though you feel completely healthy.

What is the best test for latent syphilis?

The Syphilis Antibody Cascading Reflex test is the most important test for latent syphilis because it detects specific antibodies your immune system produces in response to Treponema pallidum infection. This comprehensive test uses a cascading approach that starts with a screening test and automatically performs confirmatory tests if initial results are positive, ensuring accurate detection even when no symptoms are present. Since latent syphilis produces no visible signs, blood antibody testing is the only reliable way to diagnose this hidden infection and determine if treatment is needed to prevent progression to serious complications.

When should I get tested for latent syphilis?

You should get tested if you have had unprotected sex with someone who might have syphilis, if you have been diagnosed with another sexually transmitted infection, if you are pregnant or planning to become pregnant, or if you received treatment for syphilis in the past and need follow-up testing. Testing is also important if you have multiple sexual partners or if a sexual partner recently tested positive for syphilis, even if you feel perfectly fine. Because latent syphilis has no symptoms, regular screening is the only way to catch this hidden infection before it progresses to more serious stages.

What are the symptoms of latent syphilis?
Latent syphilis causes no symptoms at all, which is what makes this stage so dangerous. During this silent phase, you will not have any rashes, sores, fever, or other signs of infection. Your body may have completely healed from the symptoms of primary or secondary syphilis, leaving you feeling healthy and unaware that the bacteria is still present. This asymptomatic period can last for years or even decades, during which time the infection can still be transmitted to others and may eventually progress to tertiary syphilis if left untreated.
Who is at risk for latent syphilis?
Anyone who had primary or secondary syphilis that was not treated or not adequately treated is at risk for latent syphilis. People who have unprotected sex with multiple partners, men who have sex with men, individuals with HIV infection, and those who use intravenous drugs face higher risk. Pregnant women with latent syphilis can pass the infection to their baby, causing serious complications. Sexual partners of people diagnosed with syphilis and individuals living in communities with higher syphilis rates are also at increased risk for developing this silent infection.
What happens if latent syphilis is left untreated?
Untreated latent syphilis can progress to tertiary syphilis, a devastating stage that causes severe damage to your heart, brain, blood vessels, nerves, eyes, and other organs. This progression can occur years or decades after the initial infection and may result in life-threatening complications including neurosyphilis (brain and spinal cord damage), cardiovascular syphilis (heart valve damage and aortic aneurysms), blindness, paralysis, dementia, and death. Pregnant women with untreated latent syphilis can transmit the infection to their unborn baby, causing stillbirth, premature birth, or serious birth defects known as congenital syphilis.
Can latent syphilis be diagnosed with a blood test?
Yes, blood testing is the only way to diagnose latent syphilis because this stage produces no physical symptoms to examine. Blood tests detect antibodies your body has produced in response to Treponema pallidum infection, revealing the hidden presence of bacteria even when you feel perfectly healthy. The Syphilis Antibody Cascading Reflex test uses multiple testing methods in sequence to confirm the diagnosis with high accuracy, distinguishing active infection from past treated infections and ensuring you receive appropriate care.
How is latent syphilis treated?
Latent syphilis is treated with antibiotics, typically penicillin G benzathine given as one or more intramuscular injections depending on how long you have been infected. Early latent syphilis (infected for less than one year) usually requires a single injection, while late latent syphilis (infected for more than one year or unknown duration) requires three weekly injections. If you are allergic to penicillin, your healthcare provider may prescribe alternative antibiotics such as doxycycline or tetracycline. After treatment, you will need follow-up blood tests to ensure the antibodies are declining, which indicates successful treatment.
How can I prevent latent syphilis?
You can prevent latent syphilis by getting tested and treated promptly if you have primary or secondary syphilis, before the infection progresses to the hidden latent stage. Use condoms consistently during sexual activity, limit your number of sexual partners, and get regular STI screening if you are sexually active with new or multiple partners. Communicate openly with sexual partners about testing and STI status, and avoid sexual contact with anyone who has sores or rashes that might indicate active syphilis. Pregnant women should get tested for syphilis early in pregnancy to prevent transmission to their baby.
What can I do at home for latent syphilis?
There are no home remedies or natural treatments that can cure latent syphilis, as antibiotic treatment from a healthcare provider is absolutely necessary to eliminate the bacteria. However, you can support your overall health by maintaining a strong immune system through proper nutrition, adequate sleep, stress management, and avoiding smoking and excessive alcohol. It is crucial to complete the full course of prescribed antibiotics and attend all follow-up appointments for blood tests to confirm the treatment was successful. Inform all recent sexual partners so they can get tested and treated if needed, and abstain from sexual activity until your treatment is complete and your healthcare provider confirms you are no longer infectious.
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Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
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Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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Syphilis Antibody Cascading Reflex
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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