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Kidney disease is a condition where the kidneys gradually lose their ability to filter waste and excess fluid from the blood. It is caused by damage to the nephrons, the filtering units in the kidneys, often resulting from diabetes, high blood pressure, or chronic inflammation. The Comprehensive Metabolic Profile with eGFR is the most important test for diagnosis because it measures creatinine levels and estimated glomerular filtration rate, which directly assess kidney function.
Kidney disease is caused by damage to the nephrons, the tiny filtering units inside your kidneys that remove waste and excess fluid from your blood. Diabetes and high blood pressure are the two most common causes, as prolonged high blood sugar and elevated blood pressure damage the delicate blood vessels in the kidneys. Other causes include chronic glomerulonephritis (kidney inflammation), polycystic kidney disease, prolonged obstruction of the urinary tract, recurrent kidney infections, and autoimmune diseases like lupus.
The Comprehensive Metabolic Profile with eGFR is the most important test for kidney disease because it measures creatinine levels and calculates your estimated glomerular filtration rate (eGFR), which directly shows how well your kidneys are filtering waste from your blood. This panel also checks electrolyte balance, blood glucose, and protein levels, all of which become abnormal when kidneys are not functioning properly. Additional tests like the Urea Nitrogen (BUN) test help confirm kidney dysfunction by measuring waste products that should be filtered out, while the Calcium, Ionized, Serum and Magnesium, Serum tests assess mineral metabolism complications that occur as kidney disease progresses.
You should get tested if you have diabetes or high blood pressure, as these are the leading causes of kidney disease and regular monitoring is essential. Other reasons to test include if you notice swelling in your feet, ankles, or hands, changes in urination frequency or color, persistent fatigue, difficulty concentrating, or poor appetite. You should also consider testing if you have a family history of kidney disease, are over 60 years old, have heart disease, or take medications that can affect kidney function like lithium or long-term use of NSAIDs.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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