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Immunocompromised conditions occur when the body's immune system is weakened or suppressed, making individuals highly susceptible to serious infections and complications. They are caused by HIV/AIDS, organ transplantation requiring immunosuppressive drugs, chemotherapy, radiation therapy, or chronic steroid use. The Cytomegalovirus (CMV) Antibodies IgG test is the most important test for monitoring infection risk in immunocompromised patients.
Immunocompromised conditions are caused by factors that weaken or suppress the immune system's ability to fight infections. HIV/AIDS directly destroys CD4 T-cells, the immune system's primary defenders. Organ transplant recipients must take immunosuppressive medications like tacrolimus and cyclosporine to prevent organ rejection. Chemotherapy and radiation therapy for cancer treatment damage bone marrow where immune cells are produced. Chronic use of corticosteroids like prednisone suppresses immune function. Certain genetic disorders, autoimmune diseases requiring immunosuppressive treatment, and severe malnutrition also compromise immunity.
The Cytomegalovirus (CMV) Antibodies IgG test is the most important test for immunocompromised patients because it detects antibodies against CMV, a herpesvirus that causes severe complications in people with weakened immune systems. CMV can lead to pneumonia, gastroenteritis, hepatitis, encephalitis, and retinitis that may cause blindness in immunocompromised individuals. This test identifies whether you have been exposed to CMV (showing IgG antibodies), which helps doctors determine your infection risk and create a monitoring plan. Additional important tests include complete blood count with differential to monitor white blood cell levels, CD4 T-cell count for HIV patients, and immunoglobulin levels to assess overall immune function.
You should get tested if you are preparing for organ transplantation, recently diagnosed with HIV/AIDS, starting chemotherapy or immunosuppressive therapy, or experiencing frequent infections that don't resolve normally. Get tested immediately if you develop fever without obvious cause, unusual infections like thrush or shingles, persistent fatigue, unexplained weight loss, or night sweats. Anyone taking long-term steroids or immunosuppressive medications should have regular monitoring blood work every 3-6 months or as recommended by their healthcare provider to catch potential complications early.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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