IgG deficiency is an immunodeficiency disorder where the body produces insufficient levels of Immunoglobulin G antibodies. It is caused by B-cell dysfunction or genetic mutations affecting antibody production, leading to recurrent bacterial and viral infections. The Immunoglobulins Panel, Serum is the most important test for diagnosis as it directly measures IgG levels in the blood.
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IgG deficiency is caused by B-cell dysfunction or genetic mutations that prevent the immune system from producing adequate amounts of Immunoglobulin G antibodies. Some cases result from primary immunodeficiency disorders present from birth, while others develop later due to certain medications, cancers like leukemia or lymphoma, or chronic infections that damage antibody-producing cells. The deficiency leaves your body vulnerable to repeated bacterial and viral infections because IgG is the most abundant antibody type responsible for long-term immune protection.
The Immunoglobulins Panel, Serum is the most important test for IgG deficiency because it directly measures all major immunoglobulin types in your blood, including IgG, IgA, IgM, and IgE. This comprehensive panel identifies low IgG levels and determines whether the deficiency affects all antibody types or just IgG specifically. Your doctor may also order IgG subclass testing to identify which of the four IgG subtypes are deficient, as some people have selective deficiencies affecting only certain subclasses while maintaining normal total IgG levels.
You should get tested if you experience frequent respiratory infections like pneumonia, bronchitis, or sinus infections that occur more than four times per year, especially if they require antibiotics repeatedly. Testing is also recommended if you have chronic diarrhea, unexplained weight loss, recurring ear infections as an adult, or if you develop serious infections from bacteria that normally cause only mild illness. If you have a family history of immune disorders or if your doctor has noticed you heal slowly from infections despite treatment, an immunoglobulin panel can identify whether IgG deficiency is the underlying cause.
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What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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