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Hypoproteinemia is a condition characterized by abnormally low levels of total protein in the blood. It is caused by malnutrition, liver disease, kidney disease, or conditions that impair protein production or increase protein loss. The Protein, Total, Serum test is the most important test for diagnosis because it directly measures blood protein levels.
Hypoproteinemia is caused by conditions that reduce protein production or increase protein loss from the body. Malnutrition and inadequate dietary protein intake are common causes, especially in people with eating disorders or severe food insecurity. Liver diseases like cirrhosis impair the production of albumin and other proteins, while kidney diseases such as nephrotic syndrome cause excessive protein loss through urine. Other causes include inflammatory bowel disease, burns, and chronic infections that interfere with protein metabolism.
The Protein, Total, Serum test is the most important test for hypoproteinemia because it directly measures the total amount of protein in your blood serum. This test detects low protein levels that confirm the condition and helps determine severity. Normal total protein levels range from 6.0 to 8.3 grams per deciliter, and results below this range indicate hypoproteinemia. Your healthcare provider may order additional tests like albumin levels, liver function tests, or kidney function tests to identify the underlying cause of the protein deficiency, but the total protein test is essential for initial diagnosis and monitoring treatment progress.
You should get tested if you experience persistent swelling in your legs, ankles, or abdomen, as this edema is a hallmark sign of low protein levels. Other symptoms that warrant testing include unexplained fatigue, muscle weakness, frequent infections due to weakened immunity, or slow wound healing. People with known liver disease, kidney disease, or chronic digestive problems should get regular screening. If you have lost significant weight unintentionally or have been eating a severely restricted diet, testing can identify protein deficiency before serious complications develop.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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