Question 1

What is hypogonadism?

Accepted Answer

Hypogonadism is a medical condition where the body's sex glands produce insufficient sex hormones. It is caused by testicular or ovarian failure (primary hypogonadism) or by pituitary gland dysfunction affecting luteinizing hormone (LH) and follicle-stimulating hormone (FSH) production (secondary hypogonadism). The Testosterone, Free, Bioavailable and Total test is the most important test for diagnosis because it comprehensively measures all forms of testosterone.

Question 2

What causes hypogonadism?

Accepted Answer

Hypogonadism is caused by either direct failure of the sex glands (primary hypogonadism) or problems with the pituitary gland or hypothalamus that control hormone production (secondary hypogonadism). Primary hypogonadism results from testicular damage due to injury, infection, chemotherapy, radiation, genetic conditions like Klinefelter syndrome, or autoimmune disorders. Secondary hypogonadism occurs when the pituitary gland fails to produce adequate luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which can be caused by pituitary tumors, medications (especially opioids and steroids), obesity, aging, or chronic illnesses like type 2 diabetes.

Question 3

What is the best test for hypogonadism?

Accepted Answer

The Testosterone, Free, Bioavailable and Total test is the most important test for hypogonadism because it provides a complete picture of all testosterone forms in your body, using the highly accurate LC/MS/MS methodology. This comprehensive panel distinguishes between free testosterone (the active form available to tissues), bioavailable testosterone (loosely bound and readily usable), and total testosterone (the complete amount in your blood). For complete diagnosis, your healthcare provider may also order Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) tests to determine whether the problem originates in the sex glands themselves or in the pituitary gland that controls them. In some cases, Estradiol testing is also recommended since testosterone converts to estradiol, and abnormal ratios can indicate hormonal imbalances.

Question 4

When should I get tested for hypogonadism?

Accepted Answer

You should get tested if you experience persistent symptoms like reduced sex drive, erectile dysfunction, chronic fatigue, difficulty building muscle despite exercise, unexplained weight gain, mood changes including depression or irritability, or decreased energy levels. Men over 40 should consider testing if they notice declining physical performance, reduced morning erections, or loss of body hair. Testing is also important if you have risk factors such as obesity, type 2 diabetes, chronic opioid use, previous testicular injury or infection, cancer treatment history, or a family history of hormone disorders. Early detection allows for timely hormone replacement therapy that can significantly improve quality of life and prevent long-term complications like osteoporosis and cardiovascular problems.

Question 5

What are the symptoms of hypogonadism?

Accepted Answer

Hypogonadism symptoms vary depending on when the condition develops but commonly include low sex drive, erectile dysfunction, reduced muscle mass, increased body fat (especially around the abdomen), fatigue, and mood disturbances like depression or irritability. You might notice difficulty concentrating, memory problems, decreased energy, hot flashes, and reduced body and facial hair growth. Physical signs include smaller or softer testicles, breast tissue development (gynecomastia), and reduced bone density leading to increased fracture risk. Many men describe feeling less motivated, experiencing sleep disturbances, and noticing their physical strength declining despite maintaining exercise routines. In younger males, hypogonadism can delay puberty, causing incomplete development of secondary sexual characteristics.

Question 6

Who is at risk for hypogonadism?

Accepted Answer

Men over 40 face increased risk as testosterone naturally declines about 1% annually after age 30, though true hypogonadism is more severe than normal aging. Individuals with obesity, type 2 diabetes, metabolic syndrome, or chronic kidney or liver disease have significantly higher risk. Chronic opioid use, corticosteroid medications, and chemotherapy or radiation therapy for cancer dramatically increase risk. Men with testicular injury, mumps orchitis, undescended testicles, or genetic conditions like Klinefelter syndrome or Kallmann syndrome are at elevated risk. Sleep apnea, pituitary disorders or tumors, HIV/AIDS, and excessive alcohol consumption also contribute to hormone dysfunction. Family history of hormonal disorders or infertility increases your likelihood of developing this condition.

Question 7

What happens if hypogonadism is left untreated?

Accepted Answer

Untreated hypogonadism leads to progressive complications that significantly impact quality of life and long-term health. Bone density decreases, substantially increasing your risk of osteoporosis and fractures, particularly in the spine and hips. Muscle mass continues declining while body fat accumulates, especially dangerous visceral fat around organs that increases cardiovascular disease risk. Chronic fatigue worsens, sexual dysfunction persists, and fertility problems develop as sperm production drops. Mental health deteriorates with increased risk of depression, anxiety, and cognitive decline. Metabolic complications include worsening insulin resistance, higher diabetes risk, and unfavorable cholesterol profiles. Cardiovascular risks escalate, and overall mortality rates increase. Early treatment with hormone replacement therapy can prevent or reverse many of these complications.

Question 8

Can hypogonadism be diagnosed with a blood test?

Accepted Answer

Yes, hypogonadism is primarily diagnosed through blood tests that measure hormone levels. The most critical test measures total testosterone, ideally performed in the morning between 7-10 AM when levels peak naturally. Diagnosis typically requires two separate low testosterone readings on different days to confirm the condition. Additional blood tests measure free testosterone (the active form), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, and sometimes prolactin to determine whether you have primary hypogonadism (problem in the testes) or secondary hypogonadism (problem in the pituitary or hypothalamus). Your healthcare provider interprets these results alongside your symptoms, medical history, and physical examination to make an accurate diagnosis and develop an appropriate treatment plan.

Question 9

How is hypogonadism treated?

Accepted Answer

Hypogonadism is primarily treated with testosterone replacement therapy (TRT) available in multiple forms including injections (weekly or biweekly), topical gels (applied daily to shoulders or abdomen), skin patches, nasal gels, or pellets implanted under the skin every 3-6 months. Treatment choice depends on your preference, lifestyle, insurance coverage, and how your body responds. For secondary hypogonadism caused by pituitary problems, medications like clomiphene citrate or human chorionic gonadotropin (hCG) can stimulate natural testosterone production, which is especially beneficial if you want to preserve fertility. Addressing underlying causes is crucial—losing weight, managing diabetes, stopping problematic medications, treating sleep apnea, or removing pituitary tumors can sometimes restore normal hormone levels. Regular monitoring through blood tests ensures treatment effectiveness and safety.

Question 10

How can I prevent hypogonadism?

Accepted Answer

While you cannot prevent all causes of hypogonadism, especially genetic conditions, maintaining a healthy weight significantly reduces risk since obesity suppresses testosterone production. Regular exercise, particularly resistance training and high-intensity interval training, naturally boosts testosterone levels. Avoid chronic opioid use and minimize corticosteroid medications when possible, using them only as medically necessary. Manage chronic conditions like diabetes, high blood pressure, and sleep apnea effectively through medical treatment and lifestyle modifications. Limit alcohol consumption, avoid anabolic steroid abuse, and protect your testicles from injury during sports. Eat a balanced diet rich in zinc, vitamin D, and healthy fats, all crucial for hormone production. Manage stress through adequate sleep (7-9 hours nightly), meditation, or counseling, as chronic stress elevates cortisol, which suppresses testosterone.

Question 11

What natural remedies help with hypogonadism?

Accepted Answer

While natural approaches cannot replace medical treatment for diagnosed hypogonadism, certain lifestyle modifications support healthy testosterone levels. Resistance training and compound exercises like squats and deadlifts naturally stimulate testosterone production. Ensure adequate vitamin D through sunlight exposure or supplementation, as deficiency correlates with low testosterone. Optimize zinc intake through foods like oysters, beef, pumpkin seeds, and legumes. Include healthy fats from avocados, nuts, olive oil, and fatty fish, which provide building blocks for hormone production. Reduce sugar and processed carbohydrate intake to improve insulin sensitivity. Get 7-9 hours of quality sleep nightly, as testosterone is primarily produced during deep sleep. Minimize stress through meditation, yoga, or counseling since chronic stress elevates cortisol, which suppresses testosterone. Some men find modest benefits from herbs like ashwagandha or fenugreek, though scientific evidence is limited and these should not replace medical treatment.

Question 12

How’s this work?

Accepted Answer

Getting your blood test with us is easy, private & backed by the power of science.Long story short:
            
                In the test options, use the filters or search box to narrow your choices and find the test you want.
                If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
                Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
                If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
                When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
                Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
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Question 13

How do I know which test to get?

Accepted Answer

In the test options, find the test you want.
            If you’re not sure which test to get, we can lend a hand in finding the right option.
            Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
            After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop!
            If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

Absolutely! We totally understand that errors can happen. No worries, we're here to help you.
            Just reach out to us via text at 754-799-7833 or shoot us an email at
            support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update.
            Our awesome team will jump right in and make sure everything is sorted out and accurate for you.
            There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.
            Our lab requires an address to be listed to generate an order.

Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
            Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.
            This policy applies to all insurance companies, including federal health insurance programs like Medicare.
            If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Question 17

Can I cancel my order?

Accepted Answer

Yes.
            We get it – sometimes your needs change.
            As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.
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            You can read more about our cancellation policy here.

Question 18

How can I find a lab location near me?

Accepted Answer

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached!
            You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).
            Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.
            If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

Hypogonadism Blood Test & Low Hormone Panel

What is Hypogonadism?

What causes hypogonadism?

What is the best test for hypogonadism?

When should I get tested for hypogonadism?

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