Hyperviscosity Syndrome Blood Test

What is Hyperviscosity Syndrome?

Hyperviscosity syndrome is a serious medical condition characterized by abnormally thick blood that impairs circulation and oxygen delivery throughout the body. It is caused by elevated levels of proteins or blood cells from conditions like Waldenstrom macroglobulinemia, multiple myeloma, polycythemia vera, and leukemia. The Serum Viscosity Test is the most important test for diagnosis because it directly measures blood thickness and flow properties.

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What causes hyperviscosity syndrome?

Hyperviscosity syndrome is caused by abnormally high levels of proteins or blood cells that make the blood thick and unable to flow properly through blood vessels. The most common causes include blood cancers like Waldenstrom macroglobulinemia, multiple myeloma, polycythemia vera, and certain types of leukemia. These conditions produce excessive amounts of immunoglobulins, paraproteins, or red blood cells that increase blood thickness and impair circulation to vital organs.

What is the best test for hyperviscosity syndrome?

The Serum Viscosity Test is the most important test for hyperviscosity syndrome because it directly measures how thick your blood is and how easily it flows through blood vessels. This test quantifies the exact viscosity level in your blood serum, which confirms the diagnosis and helps determine how severe the condition is. Your doctor may also order additional tests like a complete blood count, protein electrophoresis, or immunoglobulin levels to identify the underlying cause, but the serum viscosity test remains the gold standard for diagnosing this condition.

When should I get tested for hyperviscosity syndrome?

You should get tested if you experience symptoms like severe headaches, vision changes or blurred vision, dizziness, confusion, unusual bleeding from your gums or nose, or numbness in your extremities. Testing is especially important if you have been diagnosed with blood cancers like multiple myeloma, Waldenstrom macroglobulinemia, or polycythemia vera, as these conditions put you at higher risk. Early detection through blood testing can prevent serious complications like stroke, heart problems, and organ damage.

What are the symptoms of hyperviscosity syndrome?
Symptoms of hyperviscosity syndrome develop when thick blood cannot flow properly through small blood vessels. You might notice persistent headaches, blurred or double vision, dizziness, confusion, or difficulty concentrating. Many people experience spontaneous bleeding from the nose or gums, shortness of breath, fatigue, and numbness or tingling in the hands and feet. In severe cases, the condition can cause stroke-like symptoms, seizures, or heart failure due to poor blood circulation and oxygen delivery to vital organs.
Who is at risk for hyperviscosity syndrome?
People with blood cancers are at highest risk for developing hyperviscosity syndrome. This includes those diagnosed with Waldenstrom macroglobulinemia, multiple myeloma, polycythemia vera, and certain types of leukemia. Other risk factors include autoimmune diseases that produce excessive antibodies, conditions causing elevated red blood cell counts, and disorders that increase plasma protein levels. Older adults are more commonly affected because blood cancers that cause this condition typically occur later in life.
What happens if hyperviscosity syndrome is left untreated?
Untreated hyperviscosity syndrome can lead to life-threatening complications because thick blood cannot deliver oxygen effectively to your organs and tissues. You may experience stroke, heart attack, or heart failure as your cardiovascular system struggles to pump thick blood. The condition can cause retinal vein occlusion leading to permanent vision loss, kidney failure from poor blood flow, severe bleeding disorders, and neurological damage including seizures or coma. Early diagnosis and treatment are critical to prevent these serious outcomes.
Can hyperviscosity syndrome be diagnosed with a blood test?
Yes, hyperviscosity syndrome is diagnosed with a specialized blood test called the Serum Viscosity Test that directly measures how thick your blood is. This test analyzes a sample of your blood serum to determine its flow properties and viscosity level. Your doctor will typically order additional blood tests including a complete blood count, protein electrophoresis, immunoglobulin levels, and tests for specific blood cancers to identify what is causing the increased viscosity. These tests together provide a complete picture of your condition and guide treatment decisions.
How is hyperviscosity syndrome treated?
Treatment for hyperviscosity syndrome focuses on reducing blood thickness and addressing the underlying cause. Plasmapheresis is the primary emergency treatment, which filters excess proteins or blood cells from your blood to quickly reduce viscosity. Your doctor will also treat the underlying condition causing the syndrome, such as chemotherapy for blood cancers like multiple myeloma or Waldenstrom macroglobulinemia. Additional treatments may include phlebotomy to remove excess blood in polycythemia vera, intravenous fluids to dilute blood, and medications to manage the underlying disease.
How can I prevent hyperviscosity syndrome?
Prevention focuses on managing underlying conditions that cause hyperviscosity syndrome. If you have a blood cancer or disorder that increases your risk, work closely with your healthcare team to monitor your condition regularly and follow your treatment plan carefully. Stay well-hydrated by drinking plenty of water, as dehydration can worsen blood thickness. Attend all scheduled blood tests and medical appointments so abnormal changes can be detected early. Avoid smoking and maintain a healthy lifestyle to support your overall blood and cardiovascular health.
What can I do at home for hyperviscosity syndrome?
While hyperviscosity syndrome requires medical treatment, you can support your health at home by staying well-hydrated with water and clear fluids throughout the day. Avoid dehydration from excessive caffeine or alcohol, which can make blood thicker. Monitor yourself for warning signs like severe headaches, vision changes, or unusual bleeding, and seek immediate medical attention if these occur. Follow your treatment plan carefully, take prescribed medications as directed, and keep all appointments for plasmapheresis or other therapies. Gentle physical activity as approved by your doctor can help maintain circulation.
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No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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