Hypercalcemia Blood Test

What is Hypercalcemia?

Hypercalcemia is a condition characterized by abnormally high levels of calcium in the blood. It is caused by overactive parathyroid glands (hyperparathyroidism), certain cancers, excessive vitamin D intake, or specific medications. The Calcium, Serum test is the most important test for diagnosis because it directly measures total calcium levels in the blood.

RECOMMENDED TEST Calcium, Serum
What's included
Fast & easy, results by email & SMS
No extra fees paid at the lab
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
Why Private MD Labs?
90-day money-back guarantee Lab order in minutes Save a trip to the doctor Low prices since 2005 Labs within 2 miles

What causes hypercalcemia?

Hypercalcemia is caused by overactive parathyroid glands (hyperparathyroidism), which release too much parathyroid hormone (PTH) that pulls calcium from bones into the bloodstream. Other causes include certain cancers like lung or breast cancer that release bone-breaking substances, taking too much calcium or vitamin D supplements, prolonged immobilization, thyroid disorders, and medications like lithium or thiazide diuretics. In some cases, rare genetic conditions or chronic kidney disease can also lead to elevated calcium levels.

What is the best test for hypercalcemia?

The Calcium, Serum test is the most important test for hypercalcemia because it directly measures total calcium levels in your blood and confirms whether you have elevated levels. This simple blood test serves as the primary screening tool that doctors use first. For a more detailed evaluation, the Calcium, Ionized, Serum test is essential because it measures the active form of calcium that actually affects your body, giving a more precise picture of your calcium status. Additional tests like the Comprehensive Metabolic Profile help assess how high calcium is affecting your kidneys and overall metabolism, while the Vitamin D, 1,25-Dihydroxy test identifies whether excessive vitamin D is contributing to the problem.

When should I get tested for hypercalcemia?

You should get tested if you experience persistent fatigue, excessive thirst and urination, confusion or difficulty concentrating, nausea and vomiting, constipation, bone pain or frequent fractures, or irregular heartbeat. Testing is also important if you have a history of overactive parathyroid glands, cancer, kidney stones, or if you take high doses of calcium or vitamin D supplements. If you have unexplained muscle weakness or notice changes in your mental clarity, these could be signs of elevated calcium that need evaluation.

What are the symptoms of hypercalcemia?
The symptoms of hypercalcemia range from mild to severe depending on how high your calcium levels are. Early symptoms include excessive thirst, frequent urination, fatigue, and weakness. As calcium levels rise, you might experience stomach pain, nausea, vomiting, constipation, loss of appetite, confusion, memory problems, and depression. More severe cases can cause bone pain, kidney stones, irregular heartbeat, and in extreme cases, cardiac arrhythmias or coma. Many people with mild hypercalcemia have no symptoms at all and only discover it through routine blood work.
Who is at risk for hypercalcemia?
People over 50, especially postmenopausal women, are at higher risk because parathyroid problems become more common with age. Those with a family history of hyperparathyroidism or multiple endocrine neoplasia have increased genetic risk. Cancer patients, particularly those with lung, breast, or blood cancers, face elevated risk because tumors can release calcium-raising substances. People taking lithium for bipolar disorder, thiazide diuretics for blood pressure, or high doses of calcium and vitamin D supplements are also at risk. Additionally, those who are bedridden or immobilized for long periods can develop hypercalcemia as bones release calcium into the bloodstream.
What happens if hypercalcemia is left untreated?
Untreated hypercalcemia can lead to serious complications affecting multiple organs. Your kidneys can develop stones and eventually fail due to calcium deposits and excessive workload from filtering high calcium levels. Bones become weak and prone to fractures as calcium is pulled from bone tissue into the blood. Your heart can develop dangerous irregular rhythms that may be life-threatening. The digestive system can suffer from severe constipation and stomach ulcers. Mental health effects include depression, confusion, and in severe cases, coma. Chronic high calcium also causes excessive urination leading to dehydration and electrolyte imbalances.
Can hypercalcemia be diagnosed with a blood test?
Yes, hypercalcemia is diagnosed with a simple blood test that measures calcium levels in your blood. The standard Calcium, Serum test checks total calcium, while the Calcium, Ionized test measures the active form for more precision. Blood tests also measure parathyroid hormone (PTH), vitamin D levels, and kidney function to determine the underlying cause. A comprehensive metabolic panel provides a complete picture of how high calcium is affecting your body chemistry. These tests are quick, requiring only a blood draw, and results are typically available within a few days.
How is hypercalcemia treated?
Treatment depends on the severity and underlying cause of hypercalcemia. Mild cases may only require stopping calcium and vitamin D supplements and staying well-hydrated. Moderate to severe cases often need intravenous fluids and medications like bisphosphonates that prevent bone breakdown or calcitonin that lowers calcium quickly. If overactive parathyroid glands are the cause, surgical removal of the affected gland is often the permanent solution. Cancer-related hypercalcemia requires treating the underlying cancer along with calcium-lowering medications. Your doctor may also prescribe steroids if excess vitamin D is the problem or dialysis in severe cases with kidney involvement.
How can I prevent hypercalcemia?
You can reduce your risk by avoiding excessive calcium and vitamin D supplements unless prescribed by your doctor, and always following recommended dosages. Stay well-hydrated by drinking plenty of water throughout the day, especially if you are at risk. Maintain an active lifestyle with regular weight-bearing exercise to keep bones healthy and calcium properly regulated. If you take medications like lithium or thiazide diuretics, have regular blood work to monitor calcium levels. Get routine check-ups if you have a family history of parathyroid problems, and seek medical attention promptly if you develop symptoms like excessive thirst, confusion, or bone pain.
What can I do at home for hypercalcemia?
At home, focus on drinking plenty of water throughout the day to help your kidneys flush out excess calcium and prevent dehydration. Stop taking any calcium or vitamin D supplements unless specifically instructed by your doctor. Stay physically active with regular walking or gentle exercise to help maintain proper calcium balance in your bones. Limit foods extremely high in calcium like fortified products if advised by your healthcare provider, but maintain a balanced diet. Monitor your symptoms carefully and seek immediate medical attention if you experience severe confusion, extreme weakness, irregular heartbeat, or severe nausea and vomiting, as these require urgent treatment.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Testosterone 375 ng/dL
Demo results
Normal Optimal 400 - 1000 High
375 ng/dL

What this means

Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

Us vs. Them

Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

1,000,000+ blood tests later, here's what our customers say

Google reviews 505 reviews Next
Calcium, Serum
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

Sample results

Sample image
For you & your coach Health insights Written in human language, backed by science.
Sample image
For you & your doc Classic lab report A familiar and comprehensive lab report.

Ask AI

Your 24/7 Lab Guide

Quick questions:

Which test is right for my symptoms?
What could be causing this?
When should I get tested?
A
Hi, I'm AI. I can help you find the right test, explain results, or prepare for your visit. What can I help with?
Just now
A
AI provides insights, not medical diagnoses.