Question 1

What is Hyperandrogenism?

Accepted Answer

Hyperandrogenism is a hormonal condition characterized by excessive levels of androgens (male hormones) in the body, particularly affecting women with symptoms like excessive hair growth, acne, and male-pattern baldness. It is caused by elevated levels of androgens such as dihydrotestosterone (DHT), testosterone, and androstenedione, often associated with polycystic ovary syndrome (PCOS), congenital adrenal hyperplasia, or androgen-secreting tumors. The Dihydrotestosterone (DHT) LC/MS/MS test is the most important test for diagnosis because it measures the most potent androgen responsible for characteristic hyperandrogenism symptoms.

Question 2

What causes hyperandrogenism?

Accepted Answer

Hyperandrogenism is caused by excessive production of androgens (male hormones) such as dihydrotestosterone (DHT), testosterone, and androstenedione. The most common cause is polycystic ovary syndrome (PCOS), which affects up to 10% of women of reproductive age and leads to hormonal imbalances in the ovaries. Other causes include congenital adrenal hyperplasia (an inherited disorder affecting cortisol production), androgen-secreting tumors of the ovaries or adrenal glands, and certain medications like anabolic steroids. In some cases, insulin resistance and obesity can worsen androgen production, creating a cycle of hormonal imbalance.

Question 3

What is the best test for hyperandrogenism?

Accepted Answer

The Dihydrotestosterone (DHT) LC/MS/MS test is the most important test for hyperandrogenism because it measures DHT levels with exceptional accuracy using liquid chromatography-tandem mass spectrometry technology. DHT is the most potent androgen in the body and directly causes many hyperandrogenism symptoms including excessive facial and body hair growth, acne, and male-pattern baldness in women. This test is essential because DHT levels are often elevated even when other androgen tests appear normal. Your doctor may also recommend total and free testosterone tests, androstenedione, DHEA-S, and sex hormone-binding globulin (SHBG) to get a complete picture of your androgen status and identify the underlying cause.

Question 4

When should I get tested for hyperandrogenism?

Accepted Answer

You should get tested if you experience excessive hair growth on your face, chest, or back (hirsutism), persistent acne that does not respond to typical treatments, or thinning hair on your scalp in a male-pattern distribution. Women with irregular or absent menstrual periods, difficulty getting pregnant, or signs of virilization (deepening voice, increased muscle mass, or clitoral enlargement) should also be tested. Testing is particularly important if you have been diagnosed with PCOS or have a family history of hormonal disorders. Early diagnosis helps prevent long-term complications and allows for targeted treatment to manage symptoms effectively.

Question 5

What are the symptoms of hyperandrogenism?

Accepted Answer

The most common symptoms of hyperandrogenism include hirsutism (excessive hair growth on the face, chest, back, and abdomen), severe or persistent acne, and male-pattern baldness or thinning hair on the scalp. Women may experience irregular menstrual periods, absent periods, or difficulty becoming pregnant due to irregular ovulation. More severe cases can cause virilization symptoms such as deepening of the voice, increased muscle mass, decreased breast size, and clitoral enlargement. You might also notice oily skin, weight gain (particularly around the abdomen), and dark, thick skin patches in body folds known as acanthosis nigricans. These symptoms can significantly impact quality of life and self-esteem, making early diagnosis and treatment important.

Question 6

Who is at risk for hyperandrogenism?

Accepted Answer

Women with polycystic ovary syndrome (PCOS) are at highest risk, as PCOS is the leading cause of hyperandrogenism in women of reproductive age. Those with a family history of PCOS, congenital adrenal hyperplasia, or other hormonal disorders face increased risk. Obesity and insulin resistance significantly increase the likelihood of developing hyperandrogenism because excess insulin stimulates the ovaries to produce more androgens. Women of certain ethnic backgrounds, including Hispanic, Middle Eastern, South Asian, and Mediterranean descent, have higher rates of hyperandrogenism. Additionally, those taking anabolic steroids or certain medications, as well as individuals with tumors of the ovaries or adrenal glands, are at elevated risk.

Question 7

What happens if hyperandrogenism is left untreated?

Accepted Answer

Untreated hyperandrogenism can lead to serious long-term health complications beyond cosmetic concerns. Women with persistent hyperandrogenism face increased risk of type 2 diabetes, metabolic syndrome, high blood pressure, and cardiovascular disease. Chronic anovulation (lack of ovulation) significantly increases the risk of endometrial cancer due to unopposed estrogen exposure. Fertility problems are common, with many women experiencing difficulty conceiving or recurrent pregnancy loss. The psychological impact can be severe, with increased rates of anxiety, depression, and reduced quality of life due to visible symptoms like excessive hair growth and acne. Early diagnosis and treatment can prevent or minimize these complications and improve both physical and emotional well-being.

Question 8

Can hyperandrogenism be diagnosed with a blood test?

Accepted Answer

Yes, hyperandrogenism is definitively diagnosed through blood tests that measure androgen hormone levels. The Dihydrotestosterone (DHT) LC/MS/MS test is particularly valuable because it uses highly sensitive technology to detect even subtle elevations in the most potent androgen. Your healthcare provider will typically order a panel of tests including total testosterone, free testosterone, DHEA-S, androstenedione, and sex hormone-binding globulin (SHBG) to assess your complete androgen profile. Blood tests should ideally be performed in the morning during the follicular phase of your menstrual cycle (days 3-10) for the most accurate results. These tests, combined with your symptoms and medical history, allow your doctor to confirm hyperandrogenism and identify the underlying cause.

Question 9

How is hyperandrogenism treated?

Accepted Answer

Treatment for hyperandrogenism depends on the underlying cause and your specific symptoms and goals. Hormonal birth control pills are the most common first-line treatment, as they suppress androgen production and increase sex hormone-binding globulin. Anti-androgen medications like spironolactone block the effects of androgens on hair follicles and skin, reducing hirsutism and acne. Metformin, a diabetes medication, is often prescribed for women with PCOS and insulin resistance to improve metabolic function and reduce androgen levels. For those trying to conceive, fertility medications like clomiphene or letrozole can stimulate ovulation. Lifestyle modifications including weight loss, regular exercise, and a low-glycemic diet can significantly improve androgen levels and symptoms. Cosmetic treatments like laser hair removal, electrolysis, and topical eflornithine cream can help manage unwanted hair growth.

Question 10

How can I prevent hyperandrogenism?

Accepted Answer

While genetic forms of hyperandrogenism like congenital adrenal hyperplasia cannot be prevented, you can reduce your risk of developing PCOS-related hyperandrogenism through healthy lifestyle choices. Maintaining a healthy weight through balanced nutrition and regular physical activity helps prevent insulin resistance, which triggers excess androgen production. Eating a diet rich in whole grains, lean proteins, fruits, and vegetables while limiting processed foods and added sugars supports hormonal balance. Regular exercise for at least 150 minutes per week improves insulin sensitivity and helps regulate hormone levels. Avoiding anabolic steroids and unnecessary medications that affect hormone levels is essential. If you have a family history of PCOS or hormonal disorders, regular check-ups with your healthcare provider can help detect early signs of hyperandrogenism before symptoms become severe.

Question 11

What natural remedies help with hyperandrogenism?

Accepted Answer

Several natural approaches can help manage hyperandrogenism symptoms alongside medical treatment. Spearmint tea has been shown in studies to have anti-androgen effects, with two cups daily potentially reducing hirsutism over several months. Inositol supplements, particularly myo-inositol and D-chiro-inositol, improve insulin sensitivity and may reduce androgen levels in women with PCOS. Saw palmetto extract may help block the conversion of testosterone to DHT, potentially reducing hair loss and excessive hair growth. Regular strength training and cardiovascular exercise improve insulin sensitivity and help regulate hormone levels naturally. Stress management through yoga, meditation, or mindfulness practices can lower cortisol levels, which influence androgen production. A low-glycemic, anti-inflammatory diet rich in omega-3 fatty acids, fiber, and antioxidants supports hormonal balance. Always discuss natural remedies with your healthcare provider, as they work best when combined with conventional treatment.

Question 12

How’s this work?

Accepted Answer

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Question 13

How do I know which test to get?

Accepted Answer

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Question 14

When will my lab results be available?

Accepted Answer

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Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

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Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
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Question 17

Can I cancel my order?

Accepted Answer

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Question 18

How can I find a lab location near me?

Accepted Answer

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Hyperandrogenism Blood Test

What is Hyperandrogenism?

What causes hyperandrogenism?

What is the best test for hyperandrogenism?

When should I get tested for hyperandrogenism?

References

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