Question 1

What is HSV-2 Reactivation?

Accepted Answer

HSV-2 reactivation occurs when herpes simplex virus type 2, which remains dormant in the nervous system after initial infection, becomes active again. It is caused by the reactivation of latent HSV-2 virus triggered by stress, illness, immunosuppression, or other immune system changes. The Herpes Simplex Virus 2 IgG with Reflex to HSV-2 Inhibition test is the most important test for detecting reactivation because it measures antibody levels that can indicate increased viral activity.

Question 2

What causes HSV-2 reactivation?

Accepted Answer

HSV-2 reactivation is caused by the herpes simplex virus type 2 becoming active again after lying dormant in nerve cells near the spine. Common triggers include physical or emotional stress, illness or fever, weakened immune system, hormonal changes during menstruation, excessive sun exposure, fatigue, and other infections. The virus can reactivate multiple times throughout a person's life, and some reactivations produce no visible symptoms at all, making them difficult to detect without blood testing.

Question 3

What is the best test for HSV-2 reactivation?

Accepted Answer

The Herpes Simplex Virus 2 IgG with Reflex to HSV-2 Inhibition test is the most important test for HSV-2 reactivation because it measures specific antibodies your immune system produces in response to HSV-2 viral activity. When the virus reactivates, even without symptoms, your IgG antibody levels can increase, signaling that the virus has become active. The reflex to HSV-2 inhibition component adds extra accuracy by confirming that the antibodies detected are specifically for HSV-2 and not cross-reacting with HSV-1. This blood test is particularly valuable for identifying asymptomatic reactivations that would otherwise go undetected.

Question 4

When should I get tested for HSV-2 reactivation?

Accepted Answer

You should get tested if you have a known history of HSV-2 infection and notice tingling, burning, or discomfort in the genital area even without visible sores, if you are experiencing recurring genital lesions or outbreaks, if you have been under significant stress or illness that might trigger reactivation, or if you want to monitor your viral activity especially before pregnancy or when starting a new relationship. Testing is also recommended if you are immunocompromised or taking medications that suppress your immune system, as these conditions increase the likelihood of reactivation.

Question 5

What are the symptoms of HSV-2 reactivation?

Accepted Answer

Symptoms of HSV-2 reactivation typically include painful blisters or sores in the genital area, tingling, itching, or burning sensations before sores appear, flu-like symptoms such as fever and swollen lymph nodes, pain during urination, and general discomfort in the affected area. However, many people experience asymptomatic reactivations where the virus becomes active and can be transmitted to others without producing any noticeable symptoms. Recurrent outbreaks are usually milder and shorter in duration than the initial infection.

Question 6

Who is at risk for HSV-2 reactivation?

Accepted Answer

Anyone who has been infected with HSV-2 is at risk for reactivation since the virus remains in the body for life. People with weakened immune systems due to HIV, cancer treatment, or immunosuppressive medications have higher reactivation rates. Those experiencing high levels of physical or emotional stress, illness, or fatigue are more susceptible. Women may experience reactivations related to hormonal changes during menstrual cycles or pregnancy. People with frequent outbreaks may have more active viral patterns, though reactivation frequency typically decreases over time for most individuals.

Question 7

What happens if HSV-2 reactivation is left untreated?

Accepted Answer

If HSV-2 reactivation is left untreated, the virus can cause recurrent painful outbreaks that affect quality of life and intimate relationships. Untreated reactivations increase the risk of transmitting HSV-2 to sexual partners, even during asymptomatic viral shedding periods. In pregnant women, active HSV-2 can be transmitted to the baby during delivery, potentially causing serious complications including neonatal herpes. People with compromised immune systems may experience more severe or prolonged outbreaks. Chronic recurrent outbreaks can lead to emotional distress, anxiety, and depression if not properly managed with antiviral therapy.

Question 8

Can HSV-2 reactivation be diagnosed with a blood test?

Accepted Answer

Yes, HSV-2 reactivation can be detected with a blood test that measures HSV-2 IgG antibodies. When the dormant virus reactivates, your immune system responds by producing more antibodies, which can be measured through blood testing. Blood tests are especially useful for identifying asymptomatic reactivations when no visible sores are present. The HSV-2 IgG test with reflex to inhibition provides specific confirmation of HSV-2 antibodies and can help monitor viral activity over time. While swab tests of active lesions provide direct detection of the virus during symptomatic outbreaks, blood tests offer insight into overall viral status and immune response.

Question 9

How is HSV-2 reactivation treated?

Accepted Answer

HSV-2 reactivation is treated with antiviral medications such as acyclovir, valacyclovir, or famciclovir, which reduce the severity and duration of outbreaks. For people with frequent reactivations, suppressive therapy involves taking daily antiviral medication to reduce outbreak frequency and lower the risk of transmission to partners. During active outbreaks, keeping the affected area clean and dry, avoiding tight clothing, and taking pain relievers can help manage symptoms. Treatment is most effective when started at the first sign of reactivation symptoms. Your healthcare provider can determine the best treatment approach based on your outbreak frequency and individual needs.

Question 10

How can I prevent HSV-2 reactivation?

Accepted Answer

While you cannot completely prevent HSV-2 reactivation, you can reduce outbreak frequency by managing stress through relaxation techniques, exercise, and adequate sleep, maintaining a healthy immune system with proper nutrition and regular physical activity, avoiding known personal triggers such as excessive sun exposure or certain foods, and taking daily suppressive antiviral therapy if recommended by your healthcare provider. Identifying and avoiding your specific reactivation triggers can significantly reduce outbreak frequency. Some people find that supplements like lysine may help, though scientific evidence is mixed. Consistent use of antiviral medication as prescribed is the most effective prevention strategy.

Question 11

What natural remedies help with HSV-2 reactivation?

Accepted Answer

Natural approaches that may help manage HSV-2 reactivation include applying cool compresses to affected areas for pain relief, taking warm baths with Epsom salts to soothe discomfort, using aloe vera gel for its potential soothing and healing properties, and consuming lysine-rich foods like fish, chicken, and legumes while limiting arginine-rich foods like nuts and chocolate. Immune-supporting supplements such as vitamin C, zinc, and echinacea may help strengthen your body's defenses. Stress reduction techniques including meditation, yoga, and adequate sleep are essential for preventing reactivations. While these natural remedies can provide symptom relief and support, they should complement rather than replace antiviral medications prescribed by your healthcare provider.

Question 12

How’s this work?

Accepted Answer

Getting your blood test with us is easy, private & backed by the power of science.Long story short:
            
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Question 13

How do I know which test to get?

Accepted Answer

In the test options, find the test you want.
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            Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
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Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

Absolutely! We totally understand that errors can happen. No worries, we're here to help you.
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            There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.
            Our lab requires an address to be listed to generate an order.

Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
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Question 17

Can I cancel my order?

Accepted Answer

Yes.
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Question 18

How can I find a lab location near me?

Accepted Answer

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached!
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            If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

HSV-2 Reactivation Blood Test

What is HSV-2 Reactivation?

What causes HSV-2 reactivation?

What is the best test for HSV-2 reactivation?

When should I get tested for HSV-2 reactivation?

References

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