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HIV progression is the rate at which HIV infection advances to AIDS and develops life-threatening complications. It is influenced by genetic factors, particularly Human Leukocyte Antigen (HLA) variants that regulate immune response to the virus. The HLA-A, B, C, DRB1 and DQ High Resolution test is the most important genetic test for assessing HIV progression risk.
HIV progression is caused by the human immunodeficiency virus gradually destroying CD4+ T cells, which are critical for immune system function. The virus replicates inside these cells, weakening your body's ability to fight infections and diseases. Genetic factors, particularly your HLA gene variants, significantly influence how quickly the virus damages your immune system, which is why some people progress to AIDS faster than others.
The HLA-A, B, C, DRB1 and DQ High Resolution test is the most important genetic test for assessing HIV progression risk because it identifies specific HLA gene variants that control how your immune system responds to HIV infection. Certain HLA-C alleles are scientifically associated with slower progression to AIDS, while other variants may indicate faster disease advancement. This comprehensive genetic analysis provides personalized information about your inherited predisposition to disease progression rates, helping your healthcare team develop targeted monitoring and treatment strategies based on your unique genetic profile.
You should get tested if you have recently been diagnosed with HIV and want to understand your genetic risk factors for disease progression. Testing is particularly valuable when planning long-term treatment strategies with your healthcare provider, or if you want personalized information about how your immune system genetics may influence disease advancement. Early genetic testing helps establish a baseline understanding of your progression risk, allowing for more informed decisions about monitoring frequency and treatment approaches.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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