Herpetic Keratitis Blood Test

What is Herpetic Keratitis?

Herpetic keratitis is a serious eye infection that affects the cornea and can lead to vision loss. It is caused by herpes simplex virus type 1 (HSV-1) or herpes simplex virus type 2 (HSV-2). The Herpes Simplex Virus 1 and 2 (IgG) with Reflex to HSV-2 Inhibition test is the most important test for confirming viral exposure and guiding treatment.

RECOMMENDED TEST Herpes Simplex Virus 1 and 2 (IgG), with Reflex to HSV-2 Inhibition
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What causes herpetic keratitis?

Herpetic keratitis is caused by herpes simplex virus type 1 (HSV-1) or occasionally herpes simplex virus type 2 (HSV-2). HSV-1 is the same virus that causes cold sores on the lips and face, and it can be transmitted to the eye through direct contact with infected saliva or lesions. Once the virus enters the eye, it infects the corneal tissue and can remain dormant in nerve cells, reactivating later during times of stress, illness, or weakened immunity to cause recurrent infections.

What is the best test for herpetic keratitis?

The Herpes Simplex Virus 1 and 2 (IgG) with Reflex to HSV-2 Inhibition test is the most important blood test for herpetic keratitis because it detects IgG antibodies against both HSV-1 and HSV-2, confirming whether you have been exposed to these viruses. This test is particularly valuable because it includes reflex testing to accurately differentiate between HSV-1 and HSV-2, helping your doctor understand which specific virus strain is involved in your eye infection. While the primary diagnosis is made through eye examination by an ophthalmologist, blood testing provides crucial supporting evidence of viral infection and helps guide appropriate antiviral treatment decisions.

When should I get tested for herpetic keratitis?

You should get tested if you experience eye pain, redness, blurred vision, sensitivity to light, or excessive tearing, especially if you have a history of cold sores or herpes infections. Testing is particularly important if you notice any unusual eye symptoms after a recent cold sore outbreak or if you have recurrent eye infections that keep coming back. Early detection through blood testing helps confirm the viral cause and allows your doctor to start antiviral treatment promptly to protect your vision and prevent serious complications like corneal scarring.

What are the symptoms of herpetic keratitis?
Herpetic keratitis symptoms include eye pain, redness, blurred or cloudy vision, excessive tearing, and sensitivity to light. You might notice a gritty feeling in your eye, as if something is stuck in it, along with discharge or swelling around the eye. Some people develop characteristic dendritic ulcers on the cornea that look like tiny branches, which can only be seen during an eye examination. Symptoms typically affect one eye and may be accompanied by a history of cold sores or previous herpes outbreaks.
Who is at risk for herpetic keratitis?
People who have had cold sores or oral herpes are at highest risk for herpetic keratitis, as the virus can spread from the mouth to the eyes. Contact lens wearers face increased risk due to frequent eye contact, especially if they touch their eyes after touching a cold sore. Individuals with weakened immune systems, those taking immunosuppressive medications, people under high stress, and anyone who has had previous episodes of eye herpes are also at greater risk for developing or experiencing recurrent herpetic keratitis.
What happens if herpetic keratitis is left untreated?
Untreated herpetic keratitis can lead to permanent corneal scarring, which causes chronic vision problems or blindness. The infection can penetrate deeper layers of the cornea, causing stromal keratitis that results in clouding and opacification of the cornea. Repeated infections increase the risk of complications including glaucoma, chronic inflammation, corneal thinning or perforation, and ultimately the need for corneal transplant surgery. Each recurrent episode causes additional damage, making early diagnosis and treatment essential for preserving vision.
Can herpetic keratitis be diagnosed with a blood test?
Herpetic keratitis is primarily diagnosed through comprehensive eye examination by an ophthalmologist who looks for characteristic corneal ulcers and inflammation patterns. However, blood tests play an important supporting role by detecting IgG antibodies against HSV-1 and HSV-2, confirming viral exposure and helping differentiate herpetic keratitis from other eye conditions. The blood test results combined with eye examination findings provide a complete picture that helps your doctor understand your viral status and develop the most effective treatment plan to protect your vision.
How is herpetic keratitis treated?
Herpetic keratitis is treated with antiviral medications, most commonly topical eye drops like trifluridine or ganciclovir gel applied directly to the infected eye. For more severe cases or deeper infections, oral antiviral medications such as acyclovir, valacyclovir, or famciclovir may be prescribed. Some patients require long-term suppressive antiviral therapy to prevent recurrent episodes, especially if they experience frequent outbreaks. Corticosteroid eye drops may be used cautiously in certain cases to reduce inflammation, but only under close ophthalmologist supervision as they can potentially worsen the infection.
How can I prevent herpetic keratitis?
You can prevent herpetic keratitis by avoiding touching your eyes after touching cold sores or affected areas, and washing your hands frequently and thoroughly. Do not share towels, washcloths, eye makeup, or contact lenses with others, and replace eye cosmetics after any eye infection. If you have a history of cold sores, consider taking suppressive antiviral medication during high-risk periods like intense sun exposure or stress. Contact lens wearers should practice excellent hygiene, avoid wearing lenses during cold sore outbreaks, and never use saliva to wet contact lenses.
What can I do at home for herpetic keratitis?
While home remedies cannot cure herpetic keratitis and medical treatment is essential, you can support healing by getting adequate rest to boost your immune system and applying cool, clean compresses to reduce eye discomfort. Wear sunglasses to protect your sensitive eyes from bright light, avoid rubbing or touching the infected eye, and maintain excellent hand hygiene. Take all prescribed antiviral medications exactly as directed, avoid wearing contact lenses until completely healed, and manage stress through relaxation techniques as stress can trigger viral reactivation. Always follow up with your eye doctor as scheduled to monitor healing progress.
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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Herpes Simplex Virus 1 and 2 (IgG), with Reflex to HSV-2 Inhibition
Google reviews 505 reviews
$133 $104
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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