HSV-1 (Oral Herpes) Blood Test

What is Herpes Simplex Virus Type 1 Infection?

Herpes Simplex Virus Type 1 (HSV-1) infection is a common viral infection that primarily causes oral herpes, manifesting as cold sores or fever blisters around the mouth and lips. It is caused by the herpes simplex virus type 1, which remains dormant in nerve cells after initial infection and can reactivate periodically throughout life. The Herpes Simplex Virus 1 and 2 (IgG) with Reflex to HSV-2 Inhibition test is the most important test for diagnosis because it detects specific antibodies that confirm past or current HSV-1 infection.

RECOMMENDED TEST Herpes Simplex Virus 1 and 2 (IgG), with Reflex to HSV-2 Inhibition
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What causes HSV-1 infection?

HSV-1 infection is caused by the herpes simplex virus type 1, which spreads through direct contact with infected saliva, skin, or mucous membranes. You can contract HSV-1 by kissing someone with an active cold sore, sharing utensils or lip balm, or touching a cold sore and then touching your mouth. The virus enters through small breaks in the skin or mucous membranes, travels to nerve cells, and remains dormant in your system for life, occasionally reactivating to cause outbreaks of cold sores.

What is the best test for HSV-1 infection?

The Herpes Simplex Virus 1 and 2 (IgG) with Reflex to HSV-2 Inhibition test is the most important test for HSV-1 infection because it detects IgG antibodies that your immune system produces in response to the virus. This blood test can identify HSV-1 infection even when you have no symptoms or visible cold sores, which is valuable since many people with HSV-1 never develop noticeable outbreaks. The test also includes reflex testing to distinguish HSV-1 from HSV-2, ensuring accurate diagnosis of which herpes virus type you have been exposed to.

When should I get tested for HSV-1?

You should get tested if you have recurrent cold sores or fever blisters around your mouth, have been intimate with someone who has oral herpes, notice tingling or burning sensations on your lips before sores appear, or want to know your HSV-1 status before starting a new relationship. Testing is especially important if you are pregnant or planning to become pregnant, as knowing your status helps prevent transmission to your baby. Even if you have never had symptoms, testing can reveal if you have been exposed to HSV-1, since up to 90% of infected people never experience noticeable outbreaks.

What are the symptoms of HSV-1 infection?
HSV-1 symptoms typically include painful, fluid-filled blisters or sores on or around the lips, mouth, or face, commonly called cold sores or fever blisters. Before sores appear, you might experience tingling, itching, or burning sensations at the site. Other symptoms during initial infection can include fever, swollen lymph nodes, sore throat, and general body aches. Many people with HSV-1 never develop visible symptoms, while others experience recurrent outbreaks triggered by stress, illness, sun exposure, or a weakened immune system.
Who is at risk for HSV-1 infection?
Anyone can contract HSV-1, but certain factors increase your risk, including close contact with someone who has active cold sores, sharing eating utensils or personal items like lip balm or razors, and engaging in oral-to-oral or oral-to-genital contact. Children are particularly vulnerable because HSV-1 is often transmitted through kissing from family members. People with weakened immune systems, those under significant stress, and individuals with eczema or other skin conditions have increased susceptibility to infection and more frequent outbreaks.
What happens if HSV-1 is left untreated?
If HSV-1 is left untreated, the virus remains in your body permanently and can reactivate periodically, causing recurrent cold sore outbreaks that may become more frequent or severe. Untreated HSV-1 can spread to other parts of your body, including your eyes (causing keratitis that may lead to vision loss), fingers (herpetic whitlow), or brain (encephalitis in rare cases). You also risk transmitting the virus to sexual partners or newborn babies during delivery, which can cause serious complications. While HSV-1 cannot be cured, antiviral treatment significantly reduces outbreak frequency, severity, and transmission risk.
Can HSV-1 be diagnosed with a blood test?
Yes, HSV-1 can be diagnosed with a blood test that detects IgG antibodies your immune system produces in response to the virus. Blood tests are particularly useful because they can identify HSV-1 infection even when you have no visible symptoms or active cold sores, unlike swab tests that require an active lesion. The blood test shows whether you have been exposed to HSV-1 at any point in your life, though it cannot pinpoint exactly when the infection occurred. Keep in mind that it takes several weeks after initial infection for antibodies to develop, so testing too early may produce a false negative result.
How is HSV-1 treated?
HSV-1 is treated with antiviral medications such as acyclovir, valacyclovir, or famciclovir, which reduce the severity and duration of outbreaks and help prevent transmission to others. For occasional outbreaks, your doctor may prescribe episodic therapy that you take at the first sign of symptoms. If you experience frequent or severe outbreaks, suppressive therapy involves taking daily antiviral medication to reduce outbreak frequency and viral shedding. Over-the-counter treatments and topical creams can provide symptom relief, while keeping the affected area clean and avoiding triggers like stress and sun exposure helps manage the condition long-term.
How can I prevent HSV-1 infection?
You can prevent HSV-1 infection by avoiding direct contact with cold sores or saliva from infected individuals, not sharing eating utensils, lip balm, towels, or other personal items, and refraining from kissing or oral contact when you or your partner has active sores. If you have HSV-1, wash your hands frequently, especially after touching your mouth, and avoid touching your eyes or other body parts after contact with a cold sore. Using sunscreen on your lips, managing stress, getting adequate sleep, and maintaining a strong immune system can help prevent outbreaks if you are already infected.
What natural remedies help with HSV-1?
Natural remedies that may help manage HSV-1 symptoms include applying ice or cold compresses to sores to reduce pain and swelling, using lysine supplements or lysine-rich foods like fish and chicken, and applying aloe vera gel or lemon balm to affected areas for soothing relief. Keeping your immune system strong through adequate sleep, stress management, and a balanced diet rich in vitamins C and E can help reduce outbreak frequency. While these natural approaches may provide symptom relief and support overall health, they should complement rather than replace antiviral medications prescribed by your healthcare provider for managing active outbreaks.
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Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
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Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
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We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Herpes Simplex Virus 1 and 2 (IgG), with Reflex to HSV-2 Inhibition
Google reviews 505 reviews
$133 $104
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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