Gynecomastia Blood Test

What is Gynecomastia?

Gynecomastia is the enlargement or swelling of breast tissue in males, affecting up to 70% of adolescent boys and a significant percentage of adult men. It is caused by hormonal imbalances, particularly elevated levels of estrogen (specifically estradiol) relative to testosterone. The Estradiol, Ultrasensitive, LC/MS/MS test is the most important test for diagnosis because it precisely measures the potent estrogen form directly responsible for breast tissue development in males.

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What causes gynecomastia?

Gynecomastia is caused by an imbalance between estrogen and testosterone hormones in males, specifically when estradiol (the most potent estrogen) levels become elevated relative to testosterone. This hormonal imbalance can result from natural hormonal changes during puberty or aging, medications like anabolic steroids, antidepressants, or heart medications, medical conditions including liver disease, kidney failure, or thyroid disorders, and tumors affecting hormone-producing glands. The excess estrogen stimulates breast tissue growth in males, leading to the characteristic enlargement or swelling of one or both breasts.

What is the best test for gynecomastia?

The Estradiol, Ultrasensitive, LC/MS/MS test is the most important test for gynecomastia because it precisely measures estradiol levels, which is the specific estrogen hormone directly responsible for male breast tissue enlargement. This highly sensitive test can detect even small elevations in estradiol that trigger gynecomastia. The Estrogens (Total), Serum test is also valuable as it provides a comprehensive view of all estrogen levels in your blood, helping to confirm whether excess estrogen overall is contributing to your condition. Together, these tests pinpoint the exact hormonal imbalance causing breast tissue development and help your healthcare provider identify underlying causes like medication side effects, liver problems, or endocrine disorders.

When should I get tested for gynecomastia?

You should get tested if you notice swelling, tenderness, or enlargement in one or both breasts, especially if the breast tissue feels firm or rubbery beneath the nipple area. Testing is particularly important if you are taking medications known to affect hormones, have unexplained breast changes that persist beyond a few weeks, experience breast pain or nipple discharge, or have a family history of hormonal disorders. Men who use anabolic steroids, have liver or kidney disease, or are undergoing hormonal changes during puberty or older age should also consider testing to identify treatable hormonal imbalances early.

What are the symptoms of gynecomastia?
Gynecomastia symptoms include noticeable swelling or enlargement of breast tissue in one or both breasts, which may appear uneven or asymmetrical. You might feel a firm or rubbery disk of tissue beneath the nipple area, along with breast tenderness or sensitivity to touch. Some men experience nipple discharge, though this is less common. The breast enlargement can range from a small amount of extra tissue to more pronounced development resembling female breasts, and the condition may cause psychological distress or self-consciousness about chest appearance.
Who is at risk for gynecomastia?
Adolescent boys going through puberty are at highest risk due to temporary hormonal fluctuations, with up to 70% experiencing some degree of breast enlargement. Older men over 50 are also at increased risk as testosterone levels naturally decline with age. Men taking certain medications including anabolic steroids, anti-androgens for prostate conditions, antidepressants, heart medications, or antibiotics face elevated risk. Those with medical conditions affecting hormone production such as liver disease, kidney failure, hyperthyroidism, or tumors of the testes, adrenal glands, or pituitary gland are more susceptible. Heavy alcohol use and marijuana use also increase gynecomastia risk.
What happens if gynecomastia is left untreated?
If left untreated, gynecomastia can persist indefinitely and may become permanent as the breast tissue becomes fibrotic or scarred over time, making it less responsive to hormonal treatments. While gynecomastia itself is not physically dangerous, leaving the underlying hormonal imbalance undiagnosed can mean missing serious conditions like liver disease, kidney failure, thyroid disorders, or hormone-producing tumors that require medical attention. Untreated gynecomastia can also lead to significant psychological impact, including anxiety, depression, low self-esteem, and social withdrawal due to embarrassment about chest appearance. Early testing and treatment can often reverse the condition and address any underlying health issues before they become more serious.
Can gynecomastia be diagnosed with a blood test?
Yes, gynecomastia can be diagnosed with blood tests that measure hormone levels, specifically estradiol and total estrogen levels. While a physical examination can identify breast tissue enlargement, blood tests are essential for determining the underlying hormonal cause and guiding appropriate treatment. The Estradiol, Ultrasensitive, LC/MS/MS test is particularly valuable because it precisely detects elevated levels of estradiol, the specific estrogen responsible for breast tissue growth in males. Your healthcare provider may also order additional hormone tests including testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) to get a complete picture of your hormonal balance and identify any underlying medical conditions.
How is gynecomastia treated?
Gynecomastia treatment depends on the underlying cause identified through hormone testing. If medications are causing the condition, your doctor may adjust or discontinue them. For hormonal imbalances, treatments may include medications that block estrogen effects or increase testosterone levels. Many cases in adolescent boys resolve naturally within 6 months to 2 years without intervention as hormones stabilize. If gynecomastia persists for more than 2 years or causes significant physical or psychological distress, surgical options including liposuction or mastectomy to remove excess breast tissue may be recommended. Treating underlying medical conditions like liver disease, kidney problems, or thyroid disorders often helps resolve the breast enlargement.
How can I prevent gynecomastia?
You can reduce your risk of gynecomastia by avoiding anabolic steroids and other performance-enhancing drugs that disrupt hormone balance. Limit alcohol consumption, as heavy drinking can damage the liver and affect hormone metabolism, and avoid marijuana use, which is linked to breast tissue development. If you are prescribed medications known to cause gynecomastia as a side effect, discuss alternatives with your healthcare provider. Maintaining a healthy weight through diet and exercise is important because obesity can increase estrogen production in fat tissue. Regular check-ups to monitor and manage chronic conditions like liver disease, kidney disease, or thyroid disorders can also help prevent hormone-related breast enlargement.
What natural remedies help with gynecomastia?
While natural remedies cannot cure gynecomastia caused by hormonal imbalances, certain lifestyle changes may help reduce breast tissue appearance. Regular chest exercises including push-ups, bench presses, and chest flies can strengthen pectoral muscles and improve chest contour, though they will not eliminate excess breast tissue. Maintaining a healthy weight through balanced nutrition and regular exercise helps reduce body fat that can contribute to breast enlargement. Some men find that foods rich in zinc like oysters, pumpkin seeds, and lean meats may support healthy testosterone levels. Avoiding soy products and foods high in phytoestrogens may also be beneficial. However, these approaches work best as complementary strategies alongside medical treatment, and hormone testing remains essential to identify and address the underlying cause.
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How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

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Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
Can I cancel my order?
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We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
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During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.

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* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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Estradiol, Ultrasensitive, LC/MS/MS
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