Gluten ataxia is a rare autoimmune neurological condition where the immune system attacks the cerebellum in response to gluten consumption, causing balance and coordination problems. It is caused by anti-gliadin antibodies that cross-react with brain tissue, particularly Purkinje cells in the cerebellum. The Gliadin (Deamidated Peptide) Antibody (IgG, IgA) test is the most important test for diagnosis because it detects the specific antibodies responsible for neurological damage.
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Gluten ataxia is caused by an autoimmune reaction to gluten proteins found in wheat, barley, and rye. When you eat gluten, your immune system produces anti-gliadin antibodies that mistakenly attack the cerebellum, the part of your brain responsible for balance and coordination. Unlike celiac disease which primarily affects the gut, gluten ataxia specifically targets the nervous system, leading to progressive damage to Purkinje cells in the cerebellum and resulting in unsteady gait, difficulty with fine motor movements, and coordination problems.
The Gliadin (Deamidated Peptide) Antibody (IgG, IgA) test is the most important test for gluten ataxia because it detects both types of antibodies that attack the cerebellum and cause neurological symptoms. This comprehensive test measures IgG and IgA antibodies against deamidated gliadin peptides, which are elevated in patients with gluten ataxia and indicate an active immune response to gluten. Additional testing with the Gluten (f79) IgG test can confirm the presence of gluten-specific antibodies that cross-react with nervous system tissues, providing further evidence of this autoimmune neurological condition. Early detection through these blood tests is essential for preventing further brain damage and improving symptoms through a strict gluten-free diet.
You should get tested if you experience unexplained balance problems, frequent stumbling or falling, difficulty walking in a straight line, tremors, or poor coordination that worsens over time. Testing is especially important if you have a family history of celiac disease or gluten sensitivity, or if your balance issues improve when you avoid gluten-containing foods. Early diagnosis through blood testing is crucial because starting a gluten-free diet immediately can halt further neurological damage and potentially reverse some symptoms, while delayed diagnosis may lead to permanent cerebellar damage.
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Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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