Gaucher's disease is a rare genetic disorder that causes fatty substances to accumulate in organs like the spleen, liver, and bone marrow. It is caused by a deficiency in the enzyme glucocerebrosidase, which breaks down glucocerebroside lipids. The Prostatic Acid Phosphatase (PAP) test is the most important blood test for monitoring bone involvement and skeletal complications in Gaucher's disease.
90-day money-back guarantee
Lab order in minutes
Save a trip to the doctor
Low prices since 2005
Labs within 2 miles
Gaucher's disease is caused by a deficiency in the enzyme glucocerebrosidase, which is responsible for breaking down a fatty substance called glucocerebroside. This deficiency results from mutations in the GBA gene inherited from both parents in an autosomal recessive pattern. Without enough functional enzyme, glucocerebroside accumulates in white blood cells called macrophages, which then become engorged Gaucher cells that infiltrate the spleen, liver, bone marrow, and sometimes lungs and brain, leading to organ enlargement and dysfunction.
The Prostatic Acid Phosphatase (PAP) test is the most important blood test for monitoring Gaucher's disease because it becomes elevated when fatty substances affect bone metabolism and cause skeletal complications. The Angiotensin-Converting Enzyme (ACE) test is also essential for tracking disease activity, as ACE levels increase when organs like the spleen and liver become involved. While the definitive diagnosis requires enzyme activity testing that measures glucocerebrosidase levels and genetic testing for GBA gene mutations, these blood markers help monitor disease progression and treatment response over time.
You should get tested if you have unexplained enlargement of your spleen or liver, experience bone pain or frequent fractures, have persistent fatigue and anemia, or notice easy bruising and bleeding. Testing is especially important if you have a family history of Gaucher's disease or are of Ashkenazi Jewish descent, as the condition occurs more frequently in this population. Early detection through blood work helps identify organ involvement and bone complications before they become severe, allowing for timely treatment intervention.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.
505 reviews
Sample results
Your 24/7 Lab Guide
Quick questions:
