Gastrointestinal Bleeding Blood Test

What is Gastrointestinal Bleeding?

Gastrointestinal bleeding is blood loss anywhere in the digestive tract from the esophagus to the rectum. It is caused by conditions like peptic ulcers, esophageal varices, inflammatory bowel disease, diverticulosis, or medication-induced damage from NSAIDs and acetaminophen. The Urea Nitrogen (BUN) test is the most important blood test for monitoring GI bleeding because it detects elevated levels when blood is digested and absorbed in the intestines.

RECOMMENDED TEST Urea Nitrogen (BUN)
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What causes gastrointestinal bleeding?

Gastrointestinal bleeding is caused by conditions that damage or erode the lining of the digestive tract. Peptic ulcers from Helicobacter pylori infection or NSAID use are common upper GI causes, while diverticulosis and colorectal polyps frequently cause lower GI bleeding. Esophageal varices from liver disease, inflammatory bowel disease (Crohn's disease and ulcerative colitis), and chronic use of blood thinners or high-dose acetaminophen can also trigger bleeding episodes throughout the digestive system.

What is the best test for gastrointestinal bleeding?

The Urea Nitrogen (BUN) test is the most important blood test for gastrointestinal bleeding because it detects elevated BUN levels when blood is digested and absorbed in the intestines. This elevation helps healthcare providers assess the severity and location of bleeding, as upper GI bleeds typically cause more significant BUN increases. The BasoFunction™ HRT Acetaminophen test is also essential if medication-related bleeding is suspected, as it measures acetaminophen metabolism biomarkers that indicate whether chronic high-dose use is contributing to stomach bleeding and ulcer formation.

When should I get tested for gastrointestinal bleeding?

You should get tested if you notice black, tarry stools (melena), bright red blood in your stool, vomit that looks like coffee grounds, or if you experience persistent abdominal pain with dizziness or weakness. Testing is also important if you take NSAIDs, aspirin, or high doses of acetaminophen regularly and develop stomach discomfort, or if you have a history of ulcers, liver disease, or inflammatory bowel disease. Unexplained anemia with fatigue and pale skin may indicate slow, chronic bleeding that requires immediate evaluation.

What are the symptoms of gastrointestinal bleeding?
Symptoms of gastrointestinal bleeding vary depending on location and severity. Upper GI bleeding often causes black, tarry stools (melena), vomiting blood or coffee-ground material, and abdominal pain. Lower GI bleeding typically presents as bright red blood in the stool (hematochezia) or maroon-colored stools. Both types can cause weakness, dizziness, fainting, shortness of breath, and pale skin from anemia. Chronic slow bleeding may only cause fatigue and weakness without obvious blood in the stool.
Who is at risk for gastrointestinal bleeding?
People at higher risk include those who regularly use NSAIDs, aspirin, blood thinners, or high doses of acetaminophen. Individuals with peptic ulcers, H. pylori infection, inflammatory bowel disease, liver cirrhosis with esophageal varices, or a history of GI bleeding are particularly vulnerable. Older adults, heavy alcohol users, and people with chronic kidney disease or bleeding disorders also face increased risk. Those with multiple risk factors or who combine medications without medical supervision have the highest likelihood of developing GI bleeding.
What happens if gastrointestinal bleeding is left untreated?
Untreated gastrointestinal bleeding can lead to severe anemia requiring blood transfusions, circulatory shock from rapid blood loss, and organ damage from inadequate oxygen delivery. Chronic bleeding causes progressive weakness, heart problems from overwork, and cognitive impairment from low oxygen to the brain. In severe cases, massive bleeding can be life-threatening within hours if not addressed immediately. The underlying cause, whether ulcers, tumors, or varices, may also worsen without treatment, increasing the risk of complications and making eventual treatment more difficult.
Can gastrointestinal bleeding be diagnosed with a blood test?
Blood tests cannot directly diagnose the source of gastrointestinal bleeding, but they provide crucial information about its severity and impact. The BUN test detects elevated levels from blood digestion in the intestines, while complete blood counts reveal anemia from blood loss. Acetaminophen metabolism tests identify medication-related bleeding risks. Definitive diagnosis requires endoscopy, colonoscopy, or imaging studies to visualize the bleeding site, but blood tests guide the urgency of these procedures and help monitor treatment effectiveness and recovery.
How is gastrointestinal bleeding treated?
Treatment depends on the bleeding source and severity. Endoscopy allows direct visualization and treatment through cauterization, clipping, or banding of bleeding vessels or varices. Medications include proton pump inhibitors for ulcers, antibiotics for H. pylori, and medications to reduce portal pressure in liver disease. Severe bleeding may require blood transfusions, intravenous fluids, and sometimes surgery to repair or remove damaged tissue. Discontinuing NSAIDs, aspirin, or acetaminophen is essential when these medications contribute to bleeding, and addressing underlying conditions like inflammatory bowel disease or liver cirrhosis is critical for long-term management.
How can I prevent gastrointestinal bleeding?
Prevention focuses on reducing risk factors and protecting the digestive tract lining. Use NSAIDs and aspirin only when necessary and at the lowest effective dose, preferably with food or a proton pump inhibitor. Avoid combining multiple medications that increase bleeding risk, limit alcohol consumption, and get tested and treated for H. pylori if you have a history of ulcers. Manage conditions like inflammatory bowel disease and liver disease with appropriate medical care, and discuss medication alternatives with your doctor if you have multiple risk factors for GI bleeding.
What can I do at home for gastrointestinal bleeding?
Seek immediate medical attention for any signs of GI bleeding, as home management is not appropriate for active bleeding. Once stabilized and under medical care, you can support recovery by eating a bland, easily digestible diet and staying well-hydrated. Avoid alcohol, caffeine, spicy foods, and NSAIDs that irritate the stomach lining. Take prescribed medications like proton pump inhibitors exactly as directed, and consume iron-rich foods or supplements if recommended for anemia. Rest adequately, avoid smoking, and attend all follow-up appointments to monitor healing and prevent recurrence.
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  8. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
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Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
Can I cancel my order?
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We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Urea Nitrogen (BUN)
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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